Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF

Akhavan‐Sigari, Reza; Zeraati, Malihe; Moghaddam‐Manesh, Mohammadreza; Kazemzadeh, Parya; Hosseinzadegan, Sara; Chauhan, Narendra Pal Singh; Sargazi, Ghasem

doi:10.1186/s13065-022-00804-2

Cited by 21 publications

(9 citation statements)

References 37 publications

(40 reference statements)

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“…The absorptions observed in the FT-IR spectrum ( Figure 4 ) near 655 cm −1 , 1,150 cm −1 , 1,420 cm −1 , 1710 cm −1 , and 2,900 cm −1 were related to Ti-O ( Al-Amin et al, 2016 ), C-O ( Alkhatami et al, 2023 ), C=C ( Alkhatami et al, 2023 ), C=O ( Akhavan-Sigari et al, 2022 ), and C-H ( Ahmad et al, 2022 ), respectively. The BTB has three carboxylic acid groups, but the broad band due to O-H groups (near 3,200–3,500 cm−1) was not observed in the spectrum of the final product.…”

Section: Discussionmentioning

confidence: 96%

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Altharawi,

Alqahtani,

Aldakhil

et al. 2024

Front. Chem.

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Nano compounds, especially metal-organic frameworks (MOFs), have significant properties. Among the most important properties of these compounds, which depend on their specific surface area and porosity, are biological properties, such as anticancer and antibacterial properties. In this study, a new titanium/BTB metal-organic framework (Ti/BTB-MOF) was synthesized by using titanium nitrate and 1,3,5-Tris(4-carboxyphenyl)benzene (BTB) under microwave radiation. The structure of the synthesized Ti/BTB-MOF was characterized and confirmed using X-ray diffraction (XRD) patterns, X-ray photoelectron spectroscopy (XPS) analysis, Fourier transform infrared (FT-IR) spectra, energy-dispersive X-ray (EDAX) analysis mapping, scanning electron microscope (SEM) images, thermogravimetric analysis (TGA) curves, and Brunauer–Emmett–Teller (BET) analysis. The in vitro anticancer properties of Ti/BTB-MOF were evaluated using the MTT method against MG-63/bone cancer cells and A-431/skin cancer cells. The in vitro antibacterial activity was tested using the Clinical and Laboratory Standards Institute (CLSI) guidelines. In the anticancer activity, IC50 (half-maximal inhibitory concentration) values of 152 μg/mL and 201 μg/mL for MG-63/bone cancer cells and A-431/skin cancer cells, respectively, were observed. In the antibacterial activity, minimum inhibitory concentrations (MICs) of 2–64 μg/mL were observed against studied pathogenic strains. The antimicrobial activity of Ti/BTB-MOF was higher than that of penicillin and gentamicin. Therefore, the synthesized Ti/BTB-MOF could be introduced as a suitable bioactive candidate.

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Section: Discussionmentioning

confidence: 96%

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Altharawi,

Alqahtani,

Aldakhil

et al. 2024

Front. Chem.

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“…Second, part of the results of the amino acid metabolism in CRC samples has not been experimentally verified. In the future, we can use more bioinformatics tools such as the feature-level fusion (FLF) method (Jin and Sinicrope, 2022), explore the possibility of combining targeting amino acid metabolism therapy with copper-metal organic frameworks (Akhavan-Sigari et al, 2022), and conduct more laboratory and clinical studies to further explore the underlying impact of amino acid metabolism in tumor prognosis and immune therapy response of CRC.…”

Section: Discussionmentioning

confidence: 99%

Amino acid metabolism genes associated with immunotherapy responses and clinical prognosis of colorectal cancer

Peng

Zheng

Guo

et al. 2022

Front. Mol. Biosci.

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Based on amino acid metabolism-related genes (AAMRGs), this study aimed at screening out key prognosis-related genes and finding the underlying correlation between the amino acid metabolism and tumor immune microenvironment of colorectal cancer. A total of 448 amino acid metabolism-related genes were obtained from MsigDB. The risk signature was built based on differential expression genes, univariate Cox, and LASSO analyses with 403 patients’ data downloaded from the TCGA database. Survival analysis and independence tests were performed to confirm the validity of the risk signature. Single-sample gene set enrichment analysis (ssGSEA), tumor mutation burden (TMB), the score of tumor immune dysfunction and exclusion (TIDE), the immunophenoscore obtained from The Cancer Immunome Atlas database, and the IC50 of drugs were used to find the relationship among the risk signature, immune status, immunotherapy response, and drug sensitivity of colorectal cancer. We identified five amino acid metabolism-related genes for the construction of the risk signature, including ENOPH1, ACAT1, ALDH4A1, FAS, and ASPG. The low-risk group was significantly associated with a better prognosis (p < 0.0001). In the entire set, the area under the curve (AUC) for 1, 3, and 5 years was 0.717, 0.734, and 0.764, respectively. We also discovered that the low-risk subgroup was related to more activity of immune cells, had higher expression of some immune checkpoints, and was more likely to benefit from immunotherapy. ssGSEA revealed that except the processes of glutamine histidine, lysine, tyrosine, and L-phenylalanine metabolism, the other amino acid metabolism pathways were more active in the samples with the low risk scores, whereas the activities of synthesis and transportation of most amino acids were similar. Hedgehog signaling, WNT/β-catenin signaling, mitotic, notch signaling, and TGF-β signaling were the top five pathways positively associated with the risk score. To sum up, AAMRGs were associated with the immune microenvironment of CRC patients and could be applied as biomarkers to predict the prognosis and immunotherapy response of patients.

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“…In the tests, the IZD, MIC, and MBC were measured, and the results are provided in the Results and discussion section. For the tests, the standards, guidelines, and relevant rules of the Clinical and Laboratory Standards Institute (CLSI) were used (( Igei et al, 2016 ; Abdtawfeeq et al, 2022 ; Akhavan-Sigari et al, 2022 ).…”

Section: Materials Devices and Methodsmentioning

confidence: 99%

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Abdulkadhim,

Husein Kamona,

Shamikh Al-Saedi

et al. 2024

Front. Chem.

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Recently, nanoscience, especially metal–organic frameworks (MOFs), has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation; penicillin, which is a known antibiotic; and copper metal–organic frameworks (Cu-MOFs), a new penicillinoate@copper metal–organic framework (penicillinoate@Cu-MOF) was synthesized. The structure and characterization of the newly synthesized compound were determined using FT-IR spectrums, EDAX analysis, elemental analysis, XRD patterns, SEM images, nitrogen adsorption/desorption curves, and TGA curve. Then, its antimicrobial effects were evaluated on numerous Gram-positive and Gram-negative bacterial strains and were compared with those of penicillin and gentamicin. In continuation of the biological activities, antioxidant tests were performed on the compounds using the DPPH method. For biological activities, the synthesized penicillinoate@Cu-MOF is much more effective than penicillin and Cu-MOF. The loading of penicillin on the nanostructure and the presence of copper in the final composition can be attributed to the high antibiotic properties of the synthesized composition.

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Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF

Cited by 21 publications

References 37 publications

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents

Amino acid metabolism genes associated with immunotherapy responses and clinical prognosis of colorectal cancer

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

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