Porous bone tissue scaffold concept based on shape memory PLA/Fe3O4

Zhao, Wei; Huang, Zhipeng; Liu, Liwu; Wang, Wenbo; Leng, Jinsong; Liu, Yanju

doi:10.1016/j.compscitech.2020.108563

Cited by 88 publications

(67 citation statements)

References 36 publications

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“…Under an alternating magnetic field of frequencies from 27.5 to 47.5 kHz, the magnetic nanoparticles in composite structures would be triggered to vibrate and generate heat, resulting in the deformation of the SMP matrix. After this, Zhao et al [193,194] utilized the fabrication technology again to design porous scaffold structures similar to lotus root, which were hopefully to be used for the repair and regeneration of human tissues. The above three works essentially belong to the thermal-response category.…”

Section: Magneto-responsive Active Mechanical Metamaterialsmentioning

confidence: 99%

“…[51,261,262] 3) The applications in giant machinery, such as, aerospace, including smart load-bearing and anti-impact structures, [1,27,46,181,263] morphing airfoils, [264] acoustic stealth cloaks, [48,[225][226][227] elastic mechanical cloaks, [48] reconfigurable antenna, [24,180,265,266] terahertz metadevices, [267] electromagnetic stealth system. [268][269][270] 4) The applications in biomedicine include electronic skin, [258,[271][272][273][274][275] tissue engineering, [192,194,[276][277][278][279][280] vascular stents, [54,136,[281][282][283] drug delivery carriers. [136,210,284,285] From the above discussion, the rich functions and application value of AMMs have brought great convenience to human production and life.…”

Section: Practical Applications Of Active Mechanical Metamaterialsmentioning

confidence: 99%

“…After this, Zhao et al. [ 193 , 194 ] utilized the fabrication technology again to design porous scaffold structures similar to lotus root, which were hopefully to be used for the repair and regeneration of human tissues. The above three works essentially belong to the thermal‐response category.…”

Section: Active Mechanical Metamaterials Responsive For Various Stimulus Fieldsmentioning

confidence: 99%

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Recent Progress in Active Mechanical Metamaterials and Construction Principles

et al. 2021

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Active mechanical metamaterials (AMMs) (or smart mechanical metamaterials) that combine the configurations of mechanical metamaterials and the active control of stimuli-responsive materials have been widely investigated in recent decades. The elaborate artificial microstructures of mechanical metamaterials and the stimulus response characteristics of smart materials both contribute to AMMs, making them achieve excellent properties beyond the conventional metamaterials. The micro and macro structures of the AMMs are designed based on structural construction principles such as, phase transition, strain mismatch, and mechanical instability. Considering the controllability and efficiency of the stimuli-responsive materials, physical fields such as, the temperature, chemicals, light, electric current, magnetic field, and pressure have been adopted as the external stimuli in practice. In this paper, the frontier works and the latest progress in AMMs from the aspects of the mechanics and materials are reviewed. The functions and engineering applications of the AMMs are also discussed. Finally, existing issues and future perspectives in this field are briefly described. This review is expected to provide the basis and inspiration for the follow-up research on AMMs.

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Section: Magneto-responsive Active Mechanical Metamaterialsmentioning

confidence: 99%

Section: Practical Applications Of Active Mechanical Metamaterialsmentioning

confidence: 99%

Section: Active Mechanical Metamaterials Responsive For Various Stimulus Fieldsmentioning

confidence: 99%

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Recent Progress in Active Mechanical Metamaterials and Construction Principles

et al. 2021

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“…Bone is a dynamic system which could maintain its homeostasis under small defects [ 1 ]. However, when the defects are larger than a critical-size [ 2 , 3 ], which are frequently caused by trauma, infection, tumors or other ailments [ 4 ], the bone might lose the ability to recover independently [ 5 ]. To address this problem, there are mainly two approaches nowadays —bone grafts and bone tissue engineering [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Zhang

Jia

Yang

et al. 2021

Bioactive Materials

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A novel biodegradable metal system, ZnLiCa ternary alloys, were systematically investigated both in vitro and in vivo . The ultimate tensile strength (UTS) of Zn0.8Li0.1Ca alloy reached 567.60 ± 9.56 MPa, which is comparable to pure Ti, one of the most common material used in orthopedics. The elongation of Zn0.8Li0.1Ca is 27.82 ± 18.35%, which is the highest among the ZnLiCa alloys. The in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid (SBF) showed significant acceleration than that of pure Zn. CCK-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good biocompatibility. Real-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes (ALP, COL-1, OCN and Runx-2), especially the OCN. An in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks, aiming to treat the bone defects. The Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti scaffold. Zn0.8Li0.1Ca alloy showed great potential to be applied in orthopedics, especially in the load-bearing sites.

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“…The development of innovative techniques and new biomaterials to fabricate porous, osteogenic, osteoconductive, osteoinductive, non-toxic, and biodegradable implants [ 1 , 2 ] with adequate mechanical strength is a challenge for many scientists, doctors, and engineers in the repair and treatment of bone tissue damaged by cancer, osteomyelitis, congenital defects, or accidents [ 3 , 4 ]. Composites based on ceramics (e.g., bioglasses, silica, hydroxyapatite, and titian), polymers (both natural and synthetic such as chitosan, collagen, fibrin, elastin, alginate, hyaluronic acid, polylactic acid) and hybrid bio-composites [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ] are mainly used in bone tissue engineering applications. Chitosan is an ideal, inexpensive, and readily available copolymer of d-glucosamine and N-acetyl-d-glucosamine [ 14 ] derived from the deacetylation of chitin [ 15 ] that can be used for the repair and treatment of damaged bone tissue [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical, Structural, and Biological Properties of Chitosan/Hydroxyapatite/Silica Composites for Bone Tissue Engineering

Adamski

Siuta

2021

Molecules

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The aim of this work was to fabricate novel bioactive composites based on chitosan and non-organic silica, reinforced with calcium β-glycerophosphate (Ca-GP), sodium β-glycerophosphate pentahydrate (Na-GP), and hydroxyapatite powder (HAp) in a range of concentrations using the sol–gel method. The effect of HAp, Na-GP, and Ca-GP contents on the mechanical properties, i.e., Young’s modulus, compressive strength, and yield strain, of hybrid composites was analyzed. The microstructure of the materials obtained was visualized by SEM. Moreover, the molecular interactions according to FTIR analysis and biocompatibility of composites obtained were examined. The CS/Si/HAp/Ca-GP developed from all composites analyzed was characterized by the well-developed surface of pores of two sizes: large ones of 100 μm and many smaller pores below 10 µm, the behavior of which positively influenced cell proliferation and growth, as well as compressive strength in a range of 0.3 to 10 MPa, Young’s modulus from 5.2 to 100 MPa, and volumetric shrinkage below 60%. This proved to be a promising composite for applications in tissue engineering, e.g., filling small bone defects.

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Porous bone tissue scaffold concept based on shape memory PLA/Fe3O4

Cited by 88 publications

References 36 publications

Recent Progress in Active Mechanical Metamaterials and Construction Principles

Recent Progress in Active Mechanical Metamaterials and Construction Principles

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Mechanical, Structural, and Biological Properties of Chitosan/Hydroxyapatite/Silica Composites for Bone Tissue Engineering

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