Porous Acellular Porcine Dermal Collagen Implants to Repair Fascial Defects in a Rat Model: Biomechanical Evaluation up to 180 Days

Ozog, Yves; Konstantinovic, Maja; Zheng, Fang; Spelzini, Federico; Verbist, Godelieve; Luyten, C; Ridder, Dirk De; Deprest, Jan

doi:10.1159/000235852

Cited by 9 publications

(9 citation statements)

References 55 publications

(52 reference statements)

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“…Conversely, Jenkins et al reported a 50 % area reduction and wrinkling for abdominal wall reconstruction after 3 months in mini pigs using Collamend (another cross-linked porcine dermis; Bard, Davol, RI) [ 38 ]. They explained the process by the presence of encapsulation, though we observed that process also in non-contracted ACM [ 37 ]. Contraction is, however, not the privilege of ACM, as significant contraction rates have been reported following PP implantation both in the vagina (45 %) and abdomen (10 %) 90 days after surgery [ 18 ].…”

Section: Discussionmentioning

confidence: 67%

“…Studies on abdominal insertion showed various results. Ozog et al reported minimal or unchanged dimensions in 180 days with Pelvicol in rats, however, without visible deformation [ 37 ]. Conversely, Jenkins et al reported a 50 % area reduction and wrinkling for abdominal wall reconstruction after 3 months in mini pigs using Collamend (another cross-linked porcine dermis; Bard, Davol, RI) [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Cross-linked xenogenic collagen implantation in the sheep model for vaginal surgery

et al. 2015

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The properties of meshes used in reconstructive surgery affect the host response and biomechanical characteristics of the grafted tissue. Whereas durable synthetics induce a chronic inflammation, biological grafts are usually considered as more biocompatible. The location of implantation is another determinant of the host response: the vagina is a different environment with specific function and anatomy. Herein, we evaluated a cross-linked acellular collagen matrix (ACM), pretreated by the anti-calcification procedure ADAPT® in a sheep model for vaginal surgery. Ten sheep were implanted with a cross-linked ACM, and six controls were implanted with a polypropylene (PP; 56 g/m2) control. One implant was inserted in the lower rectovaginal septum, and one was used for abdominal wall defect reconstruction. Grafts were removed after 180 days; all graft-related complications were recorded, and explants underwent bi-axial tensiometry and contractility testing. Half of ACM-implanted animals had palpable induration in the vaginal implantation area, two of these also on the abdominal implant. One animal had a vaginal exposure. Vaginal ACMs were 63 % less stiff compared to abdominal ACM explants (p = 0.01) but comparable to vaginal PP explants. Seven anterior vaginal ACM explants showed areas of graft degradation on histology. There was no overall difference in vaginal contractility. Considering histologic degradation in the anterior vaginal implant as representative for the host, posterior ACM explants of animals with degradation had a 60 % reduced contractility as compared to PP (p = 0.048). Three abdominal implants showed histologic degradation; those were more compliant than non-degraded implants. Vaginal implantation with ACM was associated with graft-related complications (GRCs) and biomechanical properties comparable to PP. Partially degraded ACM had a decreased vaginal contractility.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Cross-linked xenogenic collagen implantation in the sheep model for vaginal surgery

et al. 2015

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“…The noncross-linked SIS prosthesis examined here appeared highly degraded 180 days after implant, in agreement with the absence of SIS used to repair abdominal wall defects in dogs observed after 4 months. 18 Other authors 19 have recently tested the use of a similar prosthesis (InteXen LP, American Medical Systems, Inc, Minnetonka, MN) to repair fascial defects in a rat model. These authors described remodeling of the implant site by 180 days without compromising stress resistance and also noted the greater tensiometric strength of noncross-linked prostheses.…”

Section: Discussionmentioning

confidence: 99%

Effects of collagen prosthesis cross‐linking on long‐term tissue regeneration following the repair of an abdominal wall defect

Pascual

Rodrı́guez

Sotomayor

et al. 2012

Wound Repair Regeneration

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Collagen prostheses used to repair abdominal wall defects, depending on their pretreatment (noncross-linked vs. cross-linked), besides repair may also achieve tissue regeneration. We assessed the host tissue incorporation of different bioprostheses using a new tool that combines immunofluorescence confocal microscopy with differential interference contrast images, making it possible to distinguish newly formed collagen. Partial hernial defects in the abdominal wall of rabbits were repaired using cross-linked/noncross-linked bioprostheses. Expanded polytetrafluoroethylene (ePTFE) was used as control. After 14/30/90/180 days of implant, specimens were taken for microscopy, immunohistochemistry, and quantitative-reverse transcription-polymerase chain reaction to determine host tissue ingrowth and collagen I/III protein and 1a1/3a1 gene expression. Shrinkage and stress resistance were also examined. At 14 days, cross-linked prostheses had suffered significantly less shrinkage than ePTFE or noncross-linked prostheses. Significantly higher shrinkage was recorded for ePTFE in the longer term. Microscopy revealed encapsulation of ePTFE by neoformed tissue, while the bioprostheses became gradually infiltrated by host tissue. Noncross-linked prosthesis showed better tissue ingrowth, more intense inflammatory reaction and more rapid degradation than the cross-linked prostheses. At 14 days, cross-linked prostheses induced up-regulated collagen 1a1 and 3a1 gene expression, while noncross-linked only showed increased collagen III protein expression at 90 days postimplant. At 6 months, the tensile strengths of cross-linked prostheses were significantly greater compared with ePTFE. Our findings demonstrate that despite the cross-linked collagen prostheses promoting less tissue ingrowth than the noncross-linked meshes, they became gradually replaced by good quality host tissue and were less rapidly degraded, leading to improved stress resistance in the long term.

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“…Animal studies have explained this phenomenon and shown that in certain individuals Pelvicol is rapidly degraded. 58 TVT and PVS had equivalent success, but PVS required a longer hospital stay and more patients required short-term self-catheterization. Unfortunately no RCTs have been performed comparing the PVS to midurethral slings in the treatment of ISD which is the primary indication for a PVS in the current treatment of SUI.…”

Section: Dovepressmentioning

confidence: 89%

The treatment of female stress urinary incontinence: an evidenced-based review

Pelletier-Cameron¹,

Haraway²

2011

RRU

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Objective: To review the literature on the surgical and nonsurgical treatment options for stress urinary incontinence in women, focusing exclusively on randomized clinical trials and high quality meta-analyses. Materials and methods: A computer-aided and manual search for published randomized controlled trials and high quality meta-analyses investigating both conservative and surgical treatment options for stress urinary incontinence. In the case of a treatment that is not studied in these formats large case series have been used. Results: Articles were reviewed and the results summarized on pelvic floor physical therapy, pharmacotherapy, bulking agents, and surgery (open and minimally invasive). Conclusion: There are numerous high quality studies in the literature. It can be difficult to make definitive conclusions on the most appropriate treatment options due to the variability in the outcomes used to define success in these articles. There is also a dire lack of studies evaluating and comparing the surgical options for patients with intrinsic sphincter deficiency.

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Porous Acellular Porcine Dermal Collagen Implants to Repair Fascial Defects in a Rat Model: Biomechanical Evaluation up to 180 Days

Cited by 9 publications

References 55 publications

Cross-linked xenogenic collagen implantation in the sheep model for vaginal surgery

Cross-linked xenogenic collagen implantation in the sheep model for vaginal surgery

Effects of collagen prosthesis cross‐linking on long‐term tissue regeneration following the repair of an abdominal wall defect

The treatment of female stress urinary incontinence: an evidenced-based review

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