Porokeratosis ptychotropica: a diagnostic and therapeutic challenge

Contreras‐Ruiz, José; Toussaint–Caire, Sonia; Torres‐Camacho, Paula; Villa‐Castro, Virginia Berenice

doi:10.1111/jdv.14600

Cited by 14 publications

(15 citation statements)

References 9 publications

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“…The observation of multiple cornoid lamellae and the absence of other characteristic findings establish the diagnosis. 9 Multiple layers of concentric cornoid lamellae, as in our case, probably contribute to the verrucoid appearance of this variant of porokeratosis. Dermoscopy reveals an annular white-yellow structure demarcating a central scar like area surrounded by minimal peripheral vascularization.…”

Section: Discussionsupporting

confidence: 55%

Disseminated verrucous porokeratosis successfully treated with 5-FU followed by oral isotretinoin- a case report

Markantoni

Platsidaki

Kouris

et al. 2018

JDC

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Introduction: Multiple clinical variants of porokeratosis are known. The verrucous variant is usually confined to the buttocks (porokeratosis ptychotropica) and is one of the less commonly reported entities. Case description: We report a case of disseminated verrucous porokeratosis involving almost any area of the body, mostly the upper trunk, successfully treated with oral retinoids following topical 5-FU. Discussion: Histological examination is crucial for the diagnosis. The observation of multiple cornoid lamellae and the absence of other characteristic findings establish the diagnosis. Several therapeutic modalities have been described; therefore the approach to treatment must be individualized. Our case adds to the growing list of porokeratosis' variants and suggests that oral retinoids following topical 5-FU is a good therapeutic alternative in the treatment of the disease.

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Section: Discussionsupporting

confidence: 55%

Disseminated verrucous porokeratosis successfully treated with 5-FU followed by oral isotretinoin- a case report

Markantoni

Platsidaki

Kouris

et al. 2018

JDC

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“…Diagnosis relies on clinicopathological correlation, with its distinctive features being its distribution, recalcitrance to treatment and the presence of multiple cornoid lamellae throughout the lesions on histology. The diagnosis is often missed because, although well described in the literature, it is under‐recognized by dermatologists, and prominent secondary changes such as lichenification are often present, which obscures the cornoid lamellae both clinically and histologically 4 . Furthermore, as cornoid lamellae are often not noticed clinically, biopsies are often inadequate.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis is often missed because, although well described in the literature, it is under-recognized by dermatologists, and prominent secondary changes such as lichenification are often present, which obscures the cornoid lamellae both clinically and histologically. 4 Furthermore, as cornoid lamellae are often not noticed clinically, biopsies are often inadequate.…”

Section: P Dmentioning

confidence: 99%

An intractable under‐recognized anogenitogluteal rash

et al. 2021

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“…At that time he coined the term porokeratosis, which appears to be incorrect given the current data, as the disorder is not connected to orifices of eccrine sweat glands [3]. The disease may be divided into several types (table 1) [4][5][6].…”

mentioning

confidence: 99%

“…Classification of porokeratosis[4][5][6] type characteristicsPorokeratosis of Mibelli• Most often individual, slowly growing plaques found asymmetrically on extensor surfaces of limbs • More common in men; may appear at every age…”

mentioning

confidence: 99%

Familial porokeratosis Mibelli

Tomaszewska¹,

Dominiak²,

Zalewska-Janowska³

et al. 2018

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Introduction. Porokeratoses (PK) are a group of uncommon dermatoses, characterised by a keratinisation disorder, manifesting clinically with annular or linear, well-limited, keratotic plaques and histologically by the presence of the "cornoid lamella". Objective. To present and discuss a case of the familiar porokeratosis Mibelli in 11-year-old girl and her 40-year-old mother. Case report. We present the case of an 11-year-old girl and her 40-yearold mother with clearly demarcated, slightly atrophic annular lesions surrounded by slightly scaly hyperkeratotic ridge. In the girl, the lesions were located on the right lower limb, in the mother on both of the shins. The diagnosis was confirmed by histopathological examination. The patients were treated with topical 0.1% adapalene cream. Conclusions. The presented case is interesting because of the family occurrence of the disease. streszczenie Wprowadzenie. Porokeratozy (PK) to rzadka grupa chorób skóry, których istotą jest zaburzony proces rogowacenia naskórka. Klinicznie schorzenia te charakteryzują się występowaniem obrączkowatych bądź linijnych zmian z hiperkeratotyczną obwódką i zanikiem w części środkowej. Histologiczną cechą wszystkich wariantów choroby jest obecność zrogowaciałych blaszek: corneoid lamellae. Cel pracy. Przedstawienie i omówienie przypadku rodzinnego występowania porokeratozy Mibellego u 11-letniej dziewczynki i jej 40-letniej matki. Opis przypadku. Przedstawiono przypadek 11-letniej dziewczynki i jej 40-letniej matki ze zmianami skórnymi w postaci wyraźnie odgraniczonych, lekko zanikowych, obrączkowatych ognisk z widoczną uniesioną, delikatnie łuszczącą się hiperkeratotyczną obwódką. U dziewczynki zmiany zlokalizowane były na prawej kończynie dolnej, a u matki na obu podudziach. Rozpoznanie potwierdzono badaniem histopatologicznym. Do leczenia u obu pacjentek włączono miejscowo 0,1% adapalen w kremie. Wnioski. Przedstawiony przypadek jest interesujący ze względu na rodzinne występowanie schorzenia.

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Porokeratosis ptychotropica: a diagnostic and therapeutic challenge

Cited by 14 publications

References 9 publications

Disseminated verrucous porokeratosis successfully treated with 5-FU followed by oral isotretinoin- a case report

Disseminated verrucous porokeratosis successfully treated with 5-FU followed by oral isotretinoin- a case report

An intractable under‐recognized anogenitogluteal rash

Familial porokeratosis Mibelli

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