Porogen formulations for obtaining molecularly imprinted polymers with optimized binding properties

Schmidt, Ronald H.; Belmont, Anne-Sophie; Haupt, Karsten

doi:10.1016/j.aca.2005.03.064

Cited by 61 publications

(32 citation statements)

References 16 publications

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“…The effect of the crowding agent on the enhanced affinity may be related to the increased hydrophobicity of the microenvironment [29][30][31][32][33]. However, the polymers made with the mixture of chloroform and PS were too soft to be used for the HPLC column.…”

Section: Resultsmentioning

confidence: 93%

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Sun

Zhong

et al. 2015

Anal Bioanal Chem

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One of the main challenges in the preparation of molecularly imprinted polymers (MIPs) is the substantial initial amount of template needed because of the requirement of high load capacities for most applications. A new strategy of macromolecular crowding was suggested to solve this problem by reducing the amount of template in the polymerization recipe. In a ternary porogenic system of polystyrene (PS) (crowding agent), tetrahydrofuran, and toluene, an imprinted monolithic column with high porosity and good permeability was synthesized using a mixture of ellagic acid (template), acrylamide, and ethylene glycol dimethacrylate. The effect of polymerization factors, including monomer-template molar ratio and the molecular weight and concentration of PS, on the imprinting effect of the resulting MIP monoliths was systematically investigated. At a high ratio of monomer-template (120:1), the greatest imprinting factor of 32.4 was obtained on the MIP monolith with the aid of macromolecular crowding agent. The PS-based imprinted monolith had imprinting even at the extremely high ratio of functional monomer to template of 1510:1. Furthermore, an off-line solid-phase extraction based on the ground MIP was conducted, and the purification recovery of ellagic acid from pomegranate-rind extract was up to 80 %. In conclusion, this approach based on macromolecular crowding is simple, and is especially valuable for those applications of MIP preparation for which a rare template is used.

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Section: Resultsmentioning

confidence: 93%

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Sun

Zhong

et al. 2015

Anal Bioanal Chem

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“…2a-f, the thickness and surface morphology of each MIP layer are quite variable for different templates despite the fact that the same preparation protocol was employed for all the MIP columns. It is well known that the surface morphology and molecular recognition capability of MIP are affected by choice of porogenic solvent [22][23][24]. It is also known that not only porogenic solvent but also template molecule plays an important role in determining the surface morphology [20,25,26].…”

Section: Morphological Architecture Of Ot-mip Columnsmentioning

confidence: 99%

Examination of Template Structural Effects on CEC Chiral Separation Performance of Molecule Imprinted Polymers Made by a Generalized Preparation Protocol

et al. 2011

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Some acidic chiral templates were used to prepare open tubular (OT) molecule imprinted polymer (MIP) capillary columns to explore the effects of molecular structures of templates on chiral recognition capabilities and to verify the feasibility of the general MIP preparation protocol introduced in the previous study. The templates are phenyl carboxylic acids and their derivatives. Optimization was carried out for chiral separation of template enantiomers for each MIP column through varying pH and composition of eluent. It was found that the preparation protocol can be successfully applied for the appropriate templates with functional groups fulfilling the three-points interaction rule. The chiral separation performances were quite satisfactory for MIPs of such templates although they are yet inferior to the separation performances of the MIP columns fabricated with the templates of profen drugs (2-arylpropionic acids with a large substituent on the phenyl ring). Subtle variations of the template molecular structures have been found to be critical to enhance chiral recognition ability of the resultant MIP column.

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“…This had already been shown in earlier reports on thin MIP structures. [4,16] The size, density, and distribution of the pores are clearly similar on the MIP and the NIP. The pore sizes range from 200 to 400 nm in diameter, with a few pores of 100 nm in diameter; the values confirm the comparable physical morphologies of the 2,4-D imprinted polymer and the nonimprinted control.…”

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confidence: 90%

Combining Resonant Piezoelectric Micromembranes with Molecularly Imprinted Polymers

et al. 2007

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Porogen formulations for obtaining molecularly imprinted polymers with optimized binding properties

Cited by 61 publications

References 16 publications

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith

Examination of Template Structural Effects on CEC Chiral Separation Performance of Molecule Imprinted Polymers Made by a Generalized Preparation Protocol

Combining Resonant Piezoelectric Micromembranes with Molecularly Imprinted Polymers

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