Combining Resonant Piezoelectric Micromembranes with Molecularly Imprinted Polymers

Ayela, Cédric; Vandevelde, Fanny; Lagrange, Denis; Haupt, Karsten; Nicu, Liviu

doi:10.1002/ange.200703881

Cited by 9 publications

(10 citation statements)

References 19 publications

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“…Apart the examples described above, many other MIMs-based biomimetic sensors were developed for the detection of pesticides [256,261–263], haloacetic acids [264,265] and other organic pollutants as discussed elsewhere [151,266,267]. …”

Section: Mims-based Bio-mimetic Sensorsmentioning

confidence: 99%

Bio-Mimetic Sensors Based on Molecularly Imprinted Membranes

Algieri

Drioli

Guzzo

et al. 2014

Sensors

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An important challenge for scientific research is the production of artificial systems able to mimic the recognition mechanisms occurring at the molecular level in living systems. A valid contribution in this direction resulted from the development of molecular imprinting. By means of this technology, selective molecular recognition sites are introduced in a polymer, thus conferring it bio-mimetic properties. The potential applications of these systems include affinity separations, medical diagnostics, drug delivery, catalysis, etc. Recently, bio-sensing systems using molecularly imprinted membranes, a special form of imprinted polymers, have received the attention of scientists in various fields. In these systems imprinted membranes are used as bio-mimetic recognition elements which are integrated with a transducer component. The direct and rapid determination of an interaction between the recognition element and the target analyte (template) was an encouraging factor for the development of such systems as alternatives to traditional bio-assay methods. Due to their high stability, sensitivity and specificity, bio-mimetic sensors-based membranes are used for environmental, food, and clinical uses. This review deals with the development of molecularly imprinted polymers and their different preparation methods. Referring to the last decades, the application of these membranes as bio-mimetic sensor devices will be also reported.

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Section: Mims-based Bio-mimetic Sensorsmentioning

confidence: 99%

Bio-Mimetic Sensors Based on Molecularly Imprinted Membranes

Algieri

Drioli

Guzzo

et al. 2014

Sensors

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“…The same template molecule 2,4-D was used by Ayela et al [96], to make a combination of silicon microcantilever arrays and MIPs, coupling a resonant electrochemical system (MEMS) to a responsive template layer prepared from 4-VP and trimethylacrylate. The resonance frequency decreased in presence of 2,4-D and subsequently increased when the 2,4-D is not present.…”

Section: Advanced Polymeric Membranes: Synthesis and Applicationsmentioning

confidence: 99%

Molecularly Imprinted Membranes

2012

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Although the roots of molecularly imprinted polymers lie in the beginning of 1930s in the past century, they have had an exponential growth only 40–50 years later by the works of Wulff and especially by Mosbach. More recently, it was also proved that molecular imprinted membranes (i.e., polymer thin films) that show recognition properties at molecular level of the template molecule are used in their formation. Different procedures and potential application in separation processes and catalysis are reported. The influences of different parameters on the discrimination abilities are also discussed.

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“…Since silicon microfabrication technology allows the production of sensors with multiplexing capabilities and high integration, microelectromechanical system (MEMS) as transducers coupled to sensitive layer have greater potential in ultrasensitive piezoelectric sensors [143-145]. Recently, Haupt [146] reported the first experimental proof of concept of the combination of resonant MEMS with MIPs to fabricate the resonant piezoelectric micromembrane sensors. The micromembrane arrays were individually coated with MIPs by using a cantilever-based deposition tool to upload the molecular imprinting precursor solution, as shown in Figure 10A and B.…”

Section: Mip-based Chemosensorsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors

Guan

Liu

Wang

et al. 2008

Sensors

168

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Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synthetic recognition systems such as molecularly imprinted polymers (MIPs) usually have lower costs, higher physical/chemical stability, easier preparation and better engineering possibility than biological receptors. Molecular imprinting is one of the most efficient strategies to offer a synthetic route to artificial recognition systems by a template polymerization technique, and has attracted considerable efforts due to its importance in separation, chemo/biosensors, catalysis and biomedicine. Despite the fact that MIPs have molecular recognition ability similar to that of biological receptors, traditional bulky MIP materials usually exhibit a low binding capacity and slow binding kinetics to the target species. Moreover, the MIP materials lack the signal-output response to analyte binding events when used as recognition elements in chemo/biosensors or bioassays. Recently, various explorations have demonstrated that molecular imprinting nanotechniques may provide a potential solution to these difficulties. Many successful examples of the development of MIP-based sensors have also been reported during the past several decades. This review will begin with a brief introduction to the principle of molecular imprinting nanotechnology, and then mainly summarize various synthesis methodologies and recognition properties of MIP nanomaterials and their applications in MIP-based chemosensors. Finally, the future perspectives and efforts in MIP nanomaterials and MIP-based sensors are given.

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Combining Resonant Piezoelectric Micromembranes with Molecularly Imprinted Polymers

Cited by 9 publications

References 19 publications

Bio-Mimetic Sensors Based on Molecularly Imprinted Membranes

Bio-Mimetic Sensors Based on Molecularly Imprinted Membranes

Molecularly Imprinted Membranes

Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors

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