Poroelasticity of highly confined hydrogel films measured with a surface forces apparatus

Degen, George D.; Chen, Yen-Tsung; Chau, Allison L.; Månsson, Lisa K; Pitenis, Angela A.

doi:10.1039/d0sm01312a

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…Previous studies have demonstrated that the strength of cation- interactions is highly dependent on the distance between the cationic and aromatic components, and are effective only when these two are in close proximity. 24,26 However, similar to most reported hydrogels, [44][45][46][47][48][49][50][51] the reported hydrogels with cation- interactions are highly swollen polymeric networks. [40][41][42] In these cases, the distance between the incorporated cationic and aromatic groups are dramatically increased, which greatly weaken cation- interactions in hydrogels and thus unable their self-healing performance.…”

supporting

confidence: 77%

Nanoconfining Cation-π Interactions as a Modular Strategy to Construct Injectable Self-Healing Hydrogel

Yan

Chen

et al. 2022

CCS Chem

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Cation-π interaction is considered one of the strongest non-covalent interactions in aqueous solutions, which endows natural biomolecules (e.g., proteins) with robust wet adhesion and cohesion in humid/underwater environments. However, it still remains a challenge to construct synthetic functional materials (e.g., self-healing hydrogels) by rationally adopting the cation-π interactions. Herein, we present a facile and novel strategy to fabricate injectable selfhealing synthetic hydrogel from the self-assembly of a thermo-responsive ABA triblock copolymer via cation-π interactions, which is composed of a modified poly (Nisopropylacrylamide) (PNIPAM) incorporated with cationic and aromatic components as A block and a hydrophilic poly (ethylene oxide) (PEO) as B block. Upon thermally induced gelation, the cationic and aromatic components will be closely and densely packed into nanoconfined micelles to provide reversible and strong cation-π interactions, thereby endowing the resulting hydrogel with an eye-catching self-healing performance upon hydrogel damage. The hydrogel also exhibits an excellent thermo-responsive reversible sol-gel transition and a clear shear-thinning property that offers the developed hydrogel with the injectability. This work

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supporting

confidence: 77%

Nanoconfining Cation-π Interactions as a Modular Strategy to Construct Injectable Self-Healing Hydrogel

Yan

Chen

et al. 2022

CCS Chem

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“…Further, for poroelastic materials, we expect a stiffer network transmits greater stress through the material, driving faster fluid flows as compared to a soft network. Faster fluid flow has been associated with stiffer networks previously [34][35] . In addition, the network motion captured in the imaging device demonstrates that hydrogels undergo internal lateral shearing in response to compression and a subsequent relaxation.…”

Section: Discussionmentioning

confidence: 99%

Dynamic remodeling of fiber networks with stiff inclusions under compressive loading

2023

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“…For these conditions, the multi-spring model, the Winkler model, can be used. Other studies have used it to approximate the compression forces of hydrogels [58] and protein films. [59] The springs have a specified compression range, corresponding to the indentation.…”

Section: Discussionmentioning

confidence: 99%

Glycosaminoglycans and glycoproteins influence the elastic response of synovial fluid nanofilms on model oxide surfaces

Mann

Smith

Saltzherr

et al. 2021

Preprint

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Synovial fluid (SF) is the natural lubricant found in articulated joints, providing unique cartilage surface protecting films under confinement and relative motion. While it is known that the synergistic interactions of the macromolecular constituents provide its unique load-bearing and tribological performance, it is not fully understood how two of the main constituents, glycosaminoglycans (GAGs) and glycoproteins, regulate the formation and mechanics of robust load-bearing films. Here, we present evidence that the load-bearing capabilities, rather than the tribological performance, of the formed SF films depend strongly on its components’ integrity. For this purpose, we used a combination of enzymatic treatments, quartz crystal microbalance with dissipation (QCM-D) and the surface forces apparatus (SFA) to characterize the formation and load-bearing capabilities of SF films on model oxide (i.e., silicates) surfaces. We find that, upon cleavage of proteins, the elasticity of the films is reduced and that cleaving GAGs results in irreversible (plastic) molecular re-arrangements of the film constituents when subjected to confinement. Understanding thin film mechanics of SF can provide insight into the progression of diseases, such as arthritis, but may also be applicable to the development of new implant surface treatments or new biomimetic lubricants.GRAPHICAL ABSTRACT

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Poroelasticity of highly confined hydrogel films measured with a surface forces apparatus

Abstract: The influence of poroelasticity on the contact mechanics of thin polyacrylamide films was investigated with a surface forces apparatus (SFA).

Cited by 11 publications

References 36 publications

Nanoconfining Cation-π Interactions as a Modular Strategy to Construct Injectable Self-Healing Hydrogel

Nanoconfining Cation-π Interactions as a Modular Strategy to Construct Injectable Self-Healing Hydrogel

Dynamic remodeling of fiber networks with stiff inclusions under compressive loading

Glycosaminoglycans and glycoproteins influence the elastic response of synovial fluid nanofilms on model oxide surfaces

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