Porocarcinoma; presentation and management, a meta-analysis of 453 cases

Abstract

Backgroundporocarcinoma is a rare sort of skin cancer developing from sweat glands. Its clinical course and management are not well understood.Objectivesthe current meta-analysis is to address the presentation and management of porocarcinoma.Data sourcesWeb of Science, PubMed, MEDLINE on OVID and Google scholar were searched for English-language studies published before December 1, 2016.ResultsThe review of literature revealed 453 cases. From which 222 (49%) cases were male and female were 231 (51%). The mean age was 67.57 years. The mean duration of presentation was 5.57 years ranging from 4 days to 60 years of age. The most common site of affection is the head and neck (39.9%) followed by lower extremity (33.9%). Mass and nodule are the most common modes of presentation. Metastasis occurred at presentation in 110 (31%) cases. The most common organ to which porocarcinoma metastizes is the nearby lymph node (57.7%).ConclusionsPorocarcinoma is an aggressive skin cancer. Surgery is the main modality of treatment.Systematic review registration numberreviewregistry233.

Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab

“…Since the first description of PC by Pinkus and Mehregan, approximately 500 cases have been documented in the literature 3. A recent UK study demonstrated a rapid rise in PC incidence in the East of England,4 and using age-standardised incidence rates, estimated a rapidly increasing number of cases likely to be diagnosed over the next decade. It is possible that this trend reflects greater diagnostic awareness of the tumour morphology.…”

“…As PC is so rare, epidemiological data vary widely across small case series. A recently published meta-analysis of 453 patients reported 49% of cases were male, and 51% were female 4. The mean age was 67.5 years old, with most patients diagnosed in their seventh and eighth decades.…”

Eccrine porocarcinoma of the head and neck: Meta‐analysis of 120 cases

“…The clinical presentation of the EPC is variable. Patients usually present with a nodule (71%), ulcerated lesion (18%), or plaque (10%) 6 . The asymptomatic or painful lesion may have a wide spectrum of colors, ranging from reddish to black 10‐14 .…”

Eccrine Porocarcinoma with Zosteriform Metastasis

“…According to gender, this type of carcinoma is distributed evenly (49% in men and 51% in women). Its average age of onset is the seventh and eighth decade of life (average age of 67 years) [2]. The most frequent clinical presentation is a nodule (71% of cases), associated with warty epidermal changes and/or ulceration.…”

“…In these cases, tumors are characterized by rapid growth, ulceration, bleeding, or pain [4]. The average duration of the presentation is five years, and its most frequent location is head and neck (39%), and lower limbs (33%) [2]. Few reports in the literature describe cases of porocarcinoma in unusual places, such as vulva, soft tissue, and eyelid.…”