2020
DOI: 10.1002/hed.26178
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Eccrine porocarcinoma of the head and neck: Meta‐analysis of 120 cases

Abstract: Background The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck. Methods One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta‐analysis. Results At an average follow up of 20.48 months, the 3‐year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a s… Show more

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Cited by 24 publications
(60 citation statements)
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References 112 publications
(178 reference statements)
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“…A recent review found that in total of 92 surgically treated cases, WLE (76.7%) was most commonly performed compared with MMS (15.8%). 13 However, a smaller review of 28 cases, writes that metastasis after WLE was much higher at 61% versus only 3.6% after MMS. 4 One case reported success with WLE and adjunctive chemotherapy for lymph node metastasis.…”
Section: Discussionmentioning
confidence: 97%
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“…A recent review found that in total of 92 surgically treated cases, WLE (76.7%) was most commonly performed compared with MMS (15.8%). 13 However, a smaller review of 28 cases, writes that metastasis after WLE was much higher at 61% versus only 3.6% after MMS. 4 One case reported success with WLE and adjunctive chemotherapy for lymph node metastasis.…”
Section: Discussionmentioning
confidence: 97%
“…20 However, adjunctive treatment therapies, such as chemotherapy and radiotherapy, have been reviewed and these did not significantly improve prognosis. 13…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, great responses are not usually seen in the reported cases, and only in a few of them was a beneficial effect obtained, for example, the combination of chemotherapy (cisplatin/docetaxel) and radiation (50 Gy/25 fractions) in a patient with metastatic disease resulted in complete response [ 11 , 58 , 59 ]. De Bree et al successfully applied extensive cutaneous metastases with topical 5-fluorouracil combined with intraarterial docetaxel [ 60 ]. Complete rehabilitation in a case with multiple skin metastases under hyperthermic perfusion with the administration of melphalan and intra-arterial 5-fluorouracil was reported by Briscoe et al [ 61 ].…”
Section: Tumors With Apocrine and Eccrine Differentiationmentioning
confidence: 99%
“…Eccrine porocarcinoma (EPC), or malignant eccrine poroma, is a rare skin cancer of the cutaneous intraepidermal ducts of sweat glands. Porocarcinoma accounts for less than 0.01% of all cutaneous malignancies, and it is generally seen in adults aged 50 to 80 with conflicting information regarding gender predominance [ 1 , 2 ]. Reports show that EPC can develop de novo or originate from a pre-existing eccrine poroma, a benign growth of the sweat glands.…”
Section: Introductionmentioning
confidence: 99%