Eccrine Porocarcinoma: Avoiding Diagnostic Delay

Jarocki, Christine; Kozlow, Jeffery; Harms, Paul W.; Schmidt, Brian M.

doi:10.1177/1938640020946190

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…There was one case of periungual hidradenocarcinoma reported in the literature. This case occurred in the lateral nail fold of the 15 2006 Angiomatous hamartoma Richardson et al 16 2015 Benign poroma G€ otkay et al 17 2017 Benign poroma Fierro-Arias et al 18 2015 Benign poroma Al-Qattan et al 19 2009 Benign poroma Jayasekera et al 20 2017 Benign poroma Jagdeo et al 21 2006 Benign poroma Yorulmaz et al 22 2020 Benign poroma Moore et al 23 2008 Benign poroma Noh et al 24 2013 Benign poroma Akay et al 25 2020 Hidradenocarcinoma Bhari et al 9 2017 Porocarcinoma Palleschi et al 26 2017 Porocarcinoma van Gorp and van der Putte 10 1993 Porocarcinoma Jarocki et al 27 2020 Porocarcinoma Moussallem et al 28 2008 Porocarcinoma Requena et al 12 1990 Porocarcinoma Sobjanek et al 29 2019 Porocarcinoma Parra-Medina et al 8 2016 Porocarcinoma Ohtsuka et al 30 2002 Spiradenoma Leach and Graham. 31 2004 Spiradenoma Jha et al 32 2016 Spiradenoma Fouilloux et al 33 2001 Syringofibroadenoma Theunis et al 34 2001 Syringofibroadenoma Grady et al 35 2014 Syringoid eccrine carcinoma…”

Section: Hidradenocarcinomamentioning

confidence: 99%

A systematic review of periungual eccrine neoplasms

Rao

Knackstedt

2021

Int J Dermatology

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Eccrine tumors are a rare cutaneous adnexal neoplasm originating from the sweat glands. The periungual region represents an uncommon localization for these neoplasms. We analyzed all published demographic, clinical, and treatment data on periungual eccrine tumors. A systematic review following PRISMA guidelines was performed of articles published prior to March 2021. Articles were included in the review if a full‐text English version was available. Of the surveyed literature, 27 full‐text case reports were included in the final analysis. Benign eccrine poroma and porocarcinoma were the most common tumor subtypes (nine and eight cases, respectively). Males were only affected by poroma and porocarcinoma, while females were affected by all tumor subtypes. The first toe was the most common lower extremity affected. Misdiagnosis led to delayed treatment in 25% of cases. As such, while periungual eccrine neoplasms are rare diagnoses, the nonspecific presentations of these growths raise concerns about misdiagnosis and delayed treatment. Further research is needed related to sex‐differences in the epidemiology of these growths and into the prevalence of the first toe as a location. These tumors should be considered in the differential diagnosis for nail unit afflictions.

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Section: Hidradenocarcinomamentioning

confidence: 99%

A systematic review of periungual eccrine neoplasms

Rao

Knackstedt

2021

Int J Dermatology

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“…16 The latency between the appearance of the tumor and its diagnosis is usually quite long, from several months to dozens of years, with considerable therapeutic delay. 17,18 According to a recent metanalysis, the duration of the presentation is more than 5 years. 19 Dermoscopy is usually not diagnostic due to its nonspecific features, such as a polymorphic vascular pattern characterized by convoluted and forked and linear vessels.…”

Section: Introductionmentioning

confidence: 99%

“…The latency between the appearance of the tumor and its diagnosis is usually quite long, from several months to dozens of years, with considerable therapeutic delay 17,18 . According to a recent metanalysis, the duration of the presentation is more than 5 years 19 .…”

Section: Introductionmentioning

confidence: 99%

Porocarcinoma: an epidemiological, clinical, and dermoscopic 20‐year study

et al. 2022

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Background Porocarcinoma (PC) is a rare cutaneous adnexal tumor with a variable metastatic potential. Given the paucity of data, guidelines and specific recommendations for PC are not yet well‐established. In this study, we evaluate the disease‐specific characteristics and outcome of this rare and often underestimated tumor. Materials and method A retrospective study of the epidemiological, clinical, and dermoscopic characteristics among cases of histopathologically diagnosed PC, collected from the database of two skin cancer clinics in Italy (Firenze, Pistoia) from 2000 to 2020, was conducted. Results Among the 52 patients with 53 tumors, 31 were men (59.6%) and 21 were women (40.4%) with an age range of 49–96 years (median age 82 years). The most common locations were the head/neck region in men (34% in men vs. 17% in women) and the lower limb in women (17% in women vs. 9% in men). Forty‐eight cases (91%) underwent local excision. Of these patients, two (4%) experienced local recurrence, and one (2%) developed a second PC on a different anatomical site 1 month after the primary tumor's excision. Lymph node metastases were present in three cases (6%). Two of them have been treated surgically with adjuvant radiotherapy (both are disease‐free after a 2‐year follow‐up period), whereas the third case developed visceral metastases followed by PC‐related death. Conclusions This study, with 52 patients with 53 tumors covering a follow‐up period of more than 5 years, shows a less aggressive behavior of PC with 4% local recurrence, 6% nodal metastases, and 2% mortality.

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Eccrine Porocarcinoma: Avoiding Diagnostic Delay

Cited by 2 publications

References 26 publications

A systematic review of periungual eccrine neoplasms

A systematic review of periungual eccrine neoplasms

Porocarcinoma: an epidemiological, clinical, and dermoscopic 20‐year study

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