Porencephaly is a rare pathology and is commonly due to an encephalomalacia lesion. Both have two types: congenital or acquired, causing neurological symptoms and/or disorders such as epilepsy, intellectual disability, cognitive difficulties or impairment, and depressive-type neuropsychiatric symptoms, irritability, behavioral changes, and psychosis. Symptoms will depend on the size and location. Objective: Expose clinical data; and diagnostic and therapeutic methodology. Case: We present a 44-year-old female patient; with a personal medical history of epilepsy and neurodevelopmental disorder, who has a history of aggression and frequent seizures. Neuroimaging was performed, finding an injury due to encephalomalacia and, by neurological evaluation, it has an impression of porencephaly. Through laboratory tests, electrophysiological studies (electroencephalogram), neuroimaging and clinical evaluation. It is decided to present the clinical characteristics found in the patient who required management with antiepileptic, mood stabilizer and psychological - occupational therapies with gradual improvement of her admission symptoms.