Porcine-specific hemoglobin saturation measurements

Serianni, R. W.; Barash, Jed; Bentley, Timothy B.; Sharma, Pushpa; Fontana, John L.; Via, Darin K; Duhm, Joachim; Bünger, Rolf; Mongan, Paul D.

doi:10.1152/japplphysiol.00710.2002

Cited by 35 publications

(29 citation statements)

References 25 publications

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“…We did not correct the CO-oximetry for porcine blood. However, correction would have resulted in increased systematic bias due to shift of the human oxyhemoglobin dissociation curve to the left in comparison with pigs without affecting the main findings [26]. …”

Section: Discussionmentioning

confidence: 99%

Reliability of Pulse Oximetry during Progressive Hypoxia, Cardiopulmonary Resuscitation, and Recovery in a Piglet Model of Neonatal Hypoxic Cardiac Arrest

et al. 2017

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Background: Pulse oximetry is widely used in intensive care and emergency conditions to monitor arterial oxygenation and to guide oxygen therapy. Objective: To study the reliability of pulse oximetry in comparison with CO-oximetry in newborn piglets during progressive hypoxia, cardiac arrest, cardiopulmonary resuscitation (CPR), and after return of spontaneous circulation (ROSC). Methods: Thirty-three newborn piglets were exposed to hypoxia until asystole occurred and then resuscitated until ROSC. Arterial oxygen saturation was monitored continuously by pulse oximetry (SpO₂) with one sensor applied to the wrist of the right forelimb (FL) and another to the thigh of the left hind limb (HL). Arterial functional oxygen saturation (SaO₂) was measured at baseline and at predefined intervals during each phase of the experiment. SpO₂ was compared with coinciding SaO₂ values and bias considered whenever the difference (SpO₂ - SaO₂) was beyond ±5%. Results: Bias values were lower at the baseline measurements (-3.7 ± 2.3% in FL and -4.1 ± 3.4% in HL) as well as after ROSC (1.5 ± 4.2% in FL and 0.2 ± 4.6% in HL) with higher precision and accuracy than during other experiment phases. During hypoxia induction, cardiac arrest, and CPR, there was a marked decrease in precision and accuracy as well as an increase in bias up to 43 ± 26 and 56 ± 27% in FL and HL, respectively, over a range of SaO₂ from 13 to 51%. Conclusion: Pulse oximetry showed increased bias and decreased accuracy and precision during marked hypoxemia in a model of neonatal hypoxic cardiac arrest.

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Section: Discussionmentioning

confidence: 99%

Reliability of Pulse Oximetry during Progressive Hypoxia, Cardiopulmonary Resuscitation, and Recovery in a Piglet Model of Neonatal Hypoxic Cardiac Arrest

et al. 2017

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show abstract

Section: Discussionmentioning

confidence: 99%

Reliability of Pulse Oximetry during Cardiopulmonary Resuscitation in a Piglet Model of Neonatal Cardiac Arrest

et al. 2014

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Background: Pulse oximetry is widely used in intensive care and emergency conditions to monitor arterial oxygenation and to guide oxygen therapy. Objective: To study the reliability of pulse oximetry in comparison with CO-oximetry in newborn piglets during cardiopulmonary resuscitation (CPR). Methodology: In a prospective cohort study in 30 healthy newborn piglets, cardiac arrest was induced, and thereafter each piglet received CPR for 20 min. Arterial oxygen saturation was monitored continuously by pulse oximetry (SpO₂). Arterial blood was analyzed for functional oxygenation (SaO₂) every 2 min. SpO₂ was compared with coinciding SaO₂ values and bias considered whenever the difference (SpO₂ - SaO₂) was beyond ±5%. Results: Bias values were decreased at the baseline measurements (mean: 2.5 ± 4.6%) with higher precision and accuracy compared with values across the experiment. Two minutes after cardiac arrest, there was a marked decrease in precision and accuracy as well as an increase in bias up to 13 ± 34%, reaching a maximum of 45.6 ± 28.3% after 10 min over a mean SaO₂ range of 29-58%. Conclusion: Pulse oximetry showed increased bias and decreased accuracy and precision during CPR in a model of neonatal cardiac arrest. We recommend further studies to clarify the exact mechanisms of these false readings to improve reliability of pulse oximetry during the marked desaturation and hypoperfusion found during CPR. © 2014 S. Karger AG, Basel

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“…It replaces historical models from Adair and Hill [8,9]. Serianni et al differentiated between species; however, they presumed standard conditions (pH 7.400, PCO 2 40 mm Hg, BE 0 mval/L, temperature 37.0 • C) [7]. To model left and right shifts, a factor described by Severinghaus [10] was included to the formula of Serianni et al This factor comprises information about pH, BE, and temperature (Figures 2 and 3) [10].…”

Section: Mathematical Conversion Of Spo 2 Into Pao 2 Oscillation Amplmentioning

confidence: 99%

Observation of ventilation-induced Spo₂oscillations in pigs: first step to noninvasive detection of cyclic recruitment of atelectasis?

Bodenstein

Wang

Boehme

et al. 2010

Experimental Lung Research

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High arterial partial oxygen pressure (Pao(2)) oscillations within the respiratory cycle were described recently in experimental acute lung injury. This phenomenon has been related to cyclic recruitment of atelectasis and varying pulmonary shunt fractions. Noninvasive detection of Spo(2) (oxygen saturation measured by pulse oximetry) as an indicator of cyclic collapse of atelectasis, instead of recording Pao(2) oscillations, could be of clinical interest in critical care. Spo(2) oscillations were recorded continuously in three different cases of lung damage to demonstrate the technical feasibility of this approach. To deduce Pao(2) from Spo(2), a mathematical model of the hemoglobin dissociation curve including left and right shifts was derived from the literature and adapted to the dynamic changes of oxygenation. Calculated Pao(2) amplitudes (derived from Spo(2) measurements) were compared to simultaneously measured fast changes of Pao(2), using a current standard method (fluorescence quenching of ruthenium). Peripheral hemoglobin saturation was capable to capture changes of Spo(2) within each respiratory cycle. For the first time, Spo(2) oscillations due to cyclic recruitment of atelectasis within a respiratory cycle were determined by photoplethysmography, a technology that can be readily applied noninvasively in clinical routine. A mathematic model to calculate the respective Pao(2) changes was developed and its applicability tested.

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Porcine-specific hemoglobin saturation measurements

Cited by 35 publications

References 25 publications

Reliability of Pulse Oximetry during Progressive Hypoxia, Cardiopulmonary Resuscitation, and Recovery in a Piglet Model of Neonatal Hypoxic Cardiac Arrest

Reliability of Pulse Oximetry during Progressive Hypoxia, Cardiopulmonary Resuscitation, and Recovery in a Piglet Model of Neonatal Hypoxic Cardiac Arrest

Reliability of Pulse Oximetry during Cardiopulmonary Resuscitation in a Piglet Model of Neonatal Cardiac Arrest

Observation of ventilation-induced Spo₂oscillations in pigs: first step to noninvasive detection of cyclic recruitment of atelectasis?

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Porcine-specific hemoglobin saturation measurements

Cited by 35 publications

References 25 publications

Reliability of Pulse Oximetry during Progressive Hypoxia, Cardiopulmonary Resuscitation, and Recovery in a Piglet Model of Neonatal Hypoxic Cardiac Arrest

Reliability of Pulse Oximetry during Progressive Hypoxia, Cardiopulmonary Resuscitation, and Recovery in a Piglet Model of Neonatal Hypoxic Cardiac Arrest

Reliability of Pulse Oximetry during Cardiopulmonary Resuscitation in a Piglet Model of Neonatal Cardiac Arrest

Observation of ventilation-induced Spo2oscillations in pigs: first step to noninvasive detection of cyclic recruitment of atelectasis?

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Observation of ventilation-induced Spo₂oscillations in pigs: first step to noninvasive detection of cyclic recruitment of atelectasis?