Porcine deltacoronavirus causes diarrhea in various ages of field-infected pigs in China

Li, Bingxiao; Zheng, Lan-Lan; Li, Haiyan; Ding, Qingwen; Wang, Yabin; Wei, Zhanyong

doi:10.1042/bsr20190676

Cited by 20 publications

(22 citation statements)

References 29 publications

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“…Porcine deltacoronavirus could infect farmed pigs with watery diarrhea at various ages (Li et al, 2019). Our study suggests typical clinical diseases and pathologic lesions were induced by the PDCoV CH-01 strain in 5-day-old piglets, which was similar to the results of the previous observations in piglets with PDCoV infections (Dong Note: The results were presented as the mean ± standard deviation (SD); n = 3 for each treatment.…”

Section: Discussionsupporting

confidence: 89%

Porcine deltacoronavirus infection alters bacterial communities in the colon and feces of neonatal piglets

Liang

et al. 2020

MicrobiologyOpen

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Porcine deltacoronavirus (PDCoV) is a novel enteropathogenic coronavirus that causes watery diarrhea in piglets. Little is known regarding the alteration of the gut microbiota in PDCoV‐induced diarrhea piglets. In this study, 5‐day‐old piglets were experimentally infected with PDCoV strain CH‐01, and all piglets developed typical clinical disease, characterized by acute and severe watery diarrhea. Histologic lesions were limited to the villous epithelium of the duodenum and ileum. Gut microbiota profiles in the colon and feces of piglets inoculated with PDCoV were investigated using 16S rRNA sequencing. The results showed that PDCoV infection reduced bacterial diversity and significantly altered the composition of the microbiota from the phylum to the genus level in the colon and feces of piglets. Firmicutes (phylum), Lactobacillaceae (family), and Lactobacillus (genus) were significantly increased ( p < .01), while the abundance of Bacteroidetes (phylum) was markedly reduced in the colon and feces of the PDCoV‐infected piglets ( p < .01) when compared to those of the healthy piglets. Furthermore, microbial function prediction indicated that the changes in the intestinal flora also affected the nucleotide transport and metabolism, defense, translation, and transcription function of the intestinal microbiota. The current study provides new insight into the pathology and physiology of PDCoV.

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Section: Discussionsupporting

confidence: 89%

Porcine deltacoronavirus infection alters bacterial communities in the colon and feces of neonatal piglets

Liang

et al. 2020

MicrobiologyOpen

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“…Deltacoronaviruses were previously identified primarily in multiple songbird species, Asian leopard cats, and Chinese ferret badgers [2]. Pigs are the main hosts of PDCoV, and pigs of all ages are susceptible to PDCoV [15], with suckling piglets being the most susceptible [14]. PDCoV in piglets is mainly characterized by varying degrees of diarrhea, vomiting, dehydration, and histopathological lesions typical of atrophic enteritis [12].…”

Section: Host Range and Susceptibilitymentioning

confidence: 99%

“…After the PDCoV outbreaks in 2015, detailed studies of the epidemiology and evolution of PDCoV were conducted in China, which led to the accumulation of a large amount of data (Table 1). To date, PDCoV infection has been reported in 26 provinces of China, including all major traditional breeding areas [15,27,[62][63][64][65][66][67][68][69][70][71][72][73][74][75].…”

Section: Epidemiology and Geographical Distribution In Chinamentioning

confidence: 99%

“…Porcine deltacoronavirus (PDCoV), a member of the genus Deltacoronavirus, is a novel swine enteropathogenic coronavirus that causes acute diarrhea, vomiting, and dehydration in neonatal piglets [11][12][13][14][15]. PDCoV was initially identified in 2012 during a molecular surveillance study in Hong Kong and emerged later in swine herds with diarrhea in Ohio (USA) in 2014 [2,16].…”

Section: Introductionmentioning

confidence: 99%

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Porcine deltacoronavirus and its prevalence in China: a review of epidemiology, evolution, and vaccine development

et al. 2021

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Porcine deltacoronavirus (PDCoV) is one of the most important enteropathogenic pathogens, and it causes enormous economic losses to the global commercial pork industry. PDCoV was initially reported in Hong Kong (China) in 2012 and subsequently emerged in swine herds with diarrhea in Ohio (USA) in 2014. Since then, it has spread to Canada, South Korea, mainland China, and several Southeast Asian countries. Information about the epidemiology, evolution, prevention, and control of PDCoV and its prevalence in China has not been comprehensively reported, especially in the last five years. This review is an update of current information on the general characteristics, epidemiology, geographical distribution, and evolutionary relationships, and the status of PDCoV vaccine development, focusing on the prevalence of PDCoV in China and vaccine research in particular. Together, this information will provide us with a greater understanding of PDCoV infection and will be helpful for establishing new strategies for controlling this virus worldwide.

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“…Porcine deltacoronavirus (PDCoV) is an emergent virus that causes gastrointestinal disease such as diarrhea, vomiting, dehydration and death in young piglets representing a major threat to swine industry Li et al, 2019;Zhang, 2016;Zhao et al, 2019). Although PDCoV by itself causes enteric disease, co-infections with other coronaviruses such as Porcine Epidemic Diarrhea Virus (PEDV) and Transmissible Gastroenteritis Virus (TGEV) or other viruses are commonly found (Dara et al, 2018;Feng et al, 2017;Niederwerder, 2018;Song et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The first isolation and whole genome characterization of Porcine Deltacoronavirus from pigs in Peru

More-Bayona

Ramírez

Hause

et al. 2020

Preprint

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Porcine Deltacoronavirus is a newly emergent enteric pathogen affecting swine farms worldwide. It has been detected in several countries in Europe, Asia and North America. Yet, it has not been reported in South America. In November 2019, an enteric disease outbreak in a pig farm located in San Martin, Peru was reported along with submission of three intestinal samples from pigs who succumbed to the disease. Samples were processed for molecular detection by qRT-PCR, viral isolation and further sequencing analysis. A taqman-based RT-PCR was performed to differentiate among the most relevant swine enteric coronaviruses described to date. All samples were positives to Porcine Deltacoronavirus with a cycle threshold (Ct) between 9-14, revealing a high viral load, while tested negatives to Porcine Epidemic diarrhea and Transmissible Gastroenteritis viruses. Following detection, viral isolation was performed using PK-15 and Vero cell lines. After 5 days of inoculation, no cytopathic effect was observed. A second blind passage allowed the observation of cytopathic effect on PK-15 cells, while it remained absent in Vero cells. One sample was processed for whole genome sequencing (NGS). In short, raw reads were imported into CLC genomics and assembled de novo. Out of 479k reads generated from the sample, 436k assembled into a 25501 bp contig which was 99.5% identical to a reference Porcine Deltacoronavirus strain from US within the North American phylogroup. Yet, there are relevant differences at the nucleotide and amino acid levels compared to previously described Porcine Deltacoronavirus strains. Altogether, our findings represent the first report of Porcine Deltacoronavirus in South America, its genomic characterization, which provides information of its evolutionary origin. Thus, this study offers new insights into the molecular epidemiology of Porcine Deltacoronavirus infections in the swine industry.

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Porcine deltacoronavirus causes diarrhea in various ages of field-infected pigs in China

Cited by 20 publications

References 29 publications

Porcine deltacoronavirus infection alters bacterial communities in the colon and feces of neonatal piglets

Porcine deltacoronavirus infection alters bacterial communities in the colon and feces of neonatal piglets

Porcine deltacoronavirus and its prevalence in China: a review of epidemiology, evolution, and vaccine development

The first isolation and whole genome characterization of Porcine Deltacoronavirus from pigs in Peru

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