Porcelain gallbladder: a clinical case and a review of the literature

Palermo, Mariano; Núñez, Marcela; Duza, Guillermo; Dixon, Mercedes Giménez; Bruno, Miguel; Tarsitano, Francisco

doi:10.1016/s2173-5077(11)70027-8

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Recent studies claim that the incidence of carcinomas in PGB ranges from 0% to 5% (5,10). Also, it was found that the complete type of PGB is not associated with GBC (5,8,11).…”

Section: Discussionmentioning

confidence: 99%

“…The results of histological and histochemical examinations show similarity of pathological changes (presence of chronic inflammation). Obviously, the idea that PGB is a type of chronic cholecystitis has a morphological basis (8). It is also known that PGB is associated with cholelithiasis in 90% of cases (13).…”

Section: Discussionmentioning

confidence: 99%

“…PGB is a rare manifestation of chronic GB disease. It has dense calcification deposits in the GB wall and can be found in 0.06-0.8% of cholecystectomies (8). The causes of PGB are exactly unknown.…”

Section: Introductionmentioning

confidence: 99%

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Morphological and crystal chemical characteristics of gallbladder biomineralization

Moskalenko¹,

Danilchenko²,

Piddubnyi³

et al. 2020

Acta fac medic Naissensis

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Pathological biomineralization can be found in some gallbladder (GB) diseases such as chronic calculous cholecystitis (CCCh), gallbladder cancer (GBC) and porcelain gallbladder (PGB).The aim of the work was to analyze the morphology of pathological biomineralization in GB tissue in CCCh, GBC and PGB.Five cases of PGB, 10 samples of CCCh and 5 cases of GBC with biomineralization were selected for this study. All samples were examined by histology, histochemistry and scanning electron microscopy with X-ray diffraction.The X-ray diffraction of mineral deposits of PGB wall and GB concretions revealed their different mineral composition. All PGB and GBC samples had the presence of hydroxyapatite. Calcium-containing GB concretions were composed of calcium carbonate with the presence of trace amounts of other calcium phosphate phases (vaterite, dolomite).We did not find cancer in all PGB cases. The different crystal phases of biominerals were found in the wall (PGB and GBC) and in the GB cavity (CCCh) during pathology development. The difference between mineral content of biominerals can be caused by various conditions and mechanisms of their formation.

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“…Recent studies claim that the incidence of carcinomas in PGB ranges from 0% to 5% (5,10). Also, it was found that the complete type of PGB is not associated with GBC (5,8,11).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Morphological and crystal chemical characteristics of gallbladder biomineralization

Moskalenko¹,

Danilchenko²,

Piddubnyi³

et al. 2020

Acta fac medic Naissensis

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“…In rare cases of chronic cholecystitis, dystrophic calcification ensues, yielding to porcelain gall bladder, which may be a precursor to carcinoma gall bladder. It is rare and seen in 0.06 to 0.8% of cholecystectomy specimens 8 . In our study, we found just one case of porcelain gall bladder out of 680 cases.…”

Section: Discussionmentioning

confidence: 99%

Diverse Histopathological Changes Due to Cholelithiasis Seen in Surgically Removed Gall Bladder Specimens

Rashid¹,

Burki²,

Ratwani³

et al. 2020

Ann Jinnah Sindh Med Uni

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Objective: To review the diverse histopathological changes found in the cholecystectomy specimens operated for gallstones Methodology: The study was conducted at surgical ward No. 26 of JPMC for 5 years from January 2012 to December 2017. As per policy, specimens from all patients with symptomatic gall stones who underwent cholecystectomy, were sent for histopathology, the reports were reviewed and frequency of different pathological changes were noted. Results: We observed not merely chronic cholecystitis but a plethora of different histopathological changes including tuberculosis, premalignant conditions and carcinomas, with almost no suspicion of existing pathology pre-operatively. Conclusion: This strengthens our belief that every gall bladder specimen should be subjected to histopathological examination.

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A porcelain gallbladder and a rapid tumor dissemination

Gomezlopez

Andrés‐Asenjo

Ortega-Loubón

2014

Annals of Medicine &Amp; Surgery

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IntroductionPorcelain gallbladder is a very rare entity that consists of a calcification of the gallbladder wall, and is associated with carcinoma in 12.5–62% of patients, although recent studies suggest weaker association.Case reportWe describe an 80-year-old woman who presented with colicky abdominal pain in the right upper quadrant, radiating to the back and associated with vomiting. Physical examination revealed jaundice, murphy's sign was negative.Hepatic-biliary tract ultrasound revealed porcelain gallbladder, she was referred to the surgical team for a scheduled cholecystectomy. A month later, she presented diffuse abdominal pain. Imaging studies showed a disseminated process affecting liver's segments, capsule, and hilum; and lungs. An aggressive surgical treatment was dismissed, and was referred to the oncology department.DiscussionThere is controversy in the harboring risk of malignancy of the porcelain gallbladder. While it seems that the current data points towards a lower risk of degeneration, it is also demonstrated that patients with gallbladder wall calcifications are indeed statistically at risk of gallbladder cancer. Laparoscopic cholecystectomy has become a safe and efficient approach recommended for patients with gallbladder symptoms directly related or unrelated to gallbladder wall calcifications. In this case, a pathological gallbladder, very quickly evolved into an inoperable tumor with a poor prognosis.ConclusionThis report heightens that with US evidence of porcelain gallbladder, an urgent CT scan should be carried out to assess an underlying malignancy, and a simple cholecystectomy should be done urgently rather than on a routine elective list to prevent possible malignant change if possible.

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Porcelain gallbladder: a clinical case and a review of the literature

Cited by 6 publications

References 11 publications

Morphological and crystal chemical characteristics of gallbladder biomineralization

Morphological and crystal chemical characteristics of gallbladder biomineralization

Diverse Histopathological Changes Due to Cholelithiasis Seen in Surgically Removed Gall Bladder Specimens

A porcelain gallbladder and a rapid tumor dissemination

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