Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography

Zhang, Yong; Zhou, Zhuang; Wu, Cheng ai; Zhao, Dongchi; Wang, Chao; Cheng, Xiaoguang; Cai, Wei; Wang, Ling; Duanmu, Yangyang; Zhang, Chenxin; Tian, Wei

doi:10.3348/kjr.2016.17.5.581

Cited by 26 publications

(35 citation statements)

References 47 publications

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“…One cohort comprised of 344 healthy women and was recruited from an ongoing study that has been running since June 2014. This ongoing study examined the degeneration of the spine and knee, described previously (22). The second cohort comprised of one hundred and seventy-two women from the Prospective Urban Rural Epidemiology (PURE) China Action on Spine and Hip status (CASH) study (23,24).…”

Section: Subjectsmentioning

confidence: 99%

Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females

Peng

et al. 2020

Quant Imaging Med Surg

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Background: Fatty infiltration, as a result of aging, is an essential biomarker of muscle degeneration. This research aimed to investigate the age-dependent change of fatty degeneration in the paraspinal muscles of healthy Chinese women. This study also explores the effect of body size on fatty infiltration of paraspinal muscles. Methods: Cross-sectional area of paraspinal muscles (CSA muscle ) and intermuscular adipose tissue (CSA IMAT ) were measured at the L3 mid-vertebral level of 516 healthy females, who underwent abdomen quantitative computed tomography (QCT) scans. Subsequently, IMAT% [CSA IMAT / (CSA IMAT + CSA muscle )] were calculated. The relationship between basic information and measurements was evaluated using Spearman correlations. Comparisons of QCT results among different BMI subgroups in different age groups were analyzed with the Kruskal-Wallis H test and LSD, post-hoc correction. Age-related changes were calculated after the adjustment of height and weight. Results: The mean CSA IMAT of 20-29 years group (n=69) and 70-79 years group (n=25) were 3.00 cm 2 and 11.06 cm 2 , respectively. While the mean CSA muscle of 20-29 years group was 38.46 cm 2 and 70-79 years group was 30.86 cm 2 . The mean IMAT% difference between 20-29 years group and 70-79 years group was −18.55%. Strong, positive non-linear associations were observed between ageing and CSA IMAT , along with IMAT% (r=0.656, P<0.01; r=0.714, P<0.01). However, CSA muscle was shown to decrease with age in a weak, negative linear fashion (r=−0.265, P<0.01). Positive relationships between BMI and CSA IMAT , CSA muscle , alongwith IMAT%, were found. Significant differences were observed between obesity and normal BMI subgroup for all variables in three age groups. CSA IMAT showed a larger age-related difference compared to CSA muscle .Conclusions: Fatty infiltration in paraspinal muscles increased with age and BMI, while muscle loss may be associated with aging. The present study provided standardized reference data for the fatty degeneration of paraspinal muscles across the adult lifespan of Chinese females, which will play a critical role in future studies.

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Section: Subjectsmentioning

confidence: 99%

Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females

Peng

et al. 2020

Quant Imaging Med Surg

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“…[24,25] A study showed that BMD values from cervical and lumber spine decreases with aging and degeneration, notwithstanding, the BMD cervical vertebrae of women has increased throughout aging and declined abruptly with menopause. [26] These findings show that the cervical vertebrae may present higher BMD values comparing with lumbar vertebrae. Women before menopausal and postmenopausal can present different values of BMD in cervical spine in contrast to men.…”

Section: Discussionmentioning

confidence: 63%

“…Women before menopausal and postmenopausal can present different values of BMD in cervical spine in contrast to men. [26] This study has several limitations, variations such as its retrospective nature and the small sample size. Another important fact is the variation between ROI positions due to authors and anatomical variation of patients.…”

Section: Discussionmentioning

confidence: 95%

Evaluation and Correlation between craniofacial bone densities and C1 and C2 cervical vertebrae using multislice computed tomography.

Morita

Silva²,

Munhoz³

et al. 2019

BDS

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Objectives: To evaluate the use of computed tomography (CT) as an osteoporosis screening tool, evaluating the relation between the bone mineral density (BMD) from maxilla and mandible with the cervical vertebrae, using the Hounsfield units (HU).Methods: It was included in this study a convenience sample of 118 multislice CT examinations from patients who underwent maxilla, mandible and cervical vertebrae (C1 and C2) simultaneously scans. For each patient, the following regions on both sides of head CT scans were assessed in sagittal slice: above maxillary central and lateral incisors apexes; maxillary tuberosity; mandible head; mandible body endosteum; mandible body trabeculae and vertebrae C1 and C2. HU were measured in each area using a 1.5 cm region of interest (ROI) positioned in the center of the slice.Results: It was verified that there is a correlation between the BMD of the C1 and C2 vertebrae and the anterior region of the maxilla. It was not found correlation between the vertebrae, C1 and C2,and the other structures analyzed.Conclusions: This study showed that this method can be a good screening tool to diagnosis ofosteoporosis, when evaluated the correlation between C1 and C2 vertebrae and anterior region of maxilla. More studies are necessary to evaluate the possibility of using CT as an osteoporosisscreening tool.

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“…This could explain the relationship between IVRO and exhibition of SAP. Furthermore, the decrease in the cancellous bone density of the cervical vertebrae 24 after orthognathic surgery can be considered as evidence of the presence of SAP. Therefore, SAP induced by IVRO can contribute to accelerated postsurgical orthodontic tooth movement.…”

Section: Discussionmentioning

confidence: 99%

Assessment of bone density changes following two-jaw surgery using multidetector computed tomography: A pilot study

et al. 2020

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The aim of this retrospective study was to evaluate the pre-and postsurgical bone densities at alveolar and extra-alveolar sites following twojaw orthognathic surgery. Methods: The sample consisted of 10 patients (mean age, 23.2 years; range, 18.0-27.8 years; 8 males, 2 females) who underwent two-jaw orthognathic surgery. A three-dimensional imaging program (Invivo 5) was used with multidetector computed tomography images taken preand postoperatively (obtained 32.3 ± 6.0 days before surgery and 5.8 ± 2.6 days after surgery, respectively) for the measurement of bone densities at the following sites: (1) alveolar bone in the maxilla and mandible, (2) extra-alveolar sites, such as the top of the head, menton (Me), condyle, and the fourth cervical vertebrae (C4). Results: When pre-and postsurgical bone densities were compared, an overall tendency of decrease in bone density was noted. Statistically significant reductions were observed in the densities of cancellous bone at several areas of the maxillary alveolar bone; cortical and cancellous bone in most areas of the mandibular alveolar bone; cortical bone in Me; and cancellous bone in C4. There was no statistically significant difference in bone density in relation to the depth of the alveolar bone. In a comparison of the bone densities between groups with and without genioplasty, there was almost no statistically significant difference. Conclusions: Accelerated tooth movement following orthognathic surgery may be confirmed with reduced bone density. In addition, this study could offer insights into bone metabolism changes following orthognathic surgery, providing direction for further investigations in this field.

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Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography

Cited by 26 publications

References 47 publications

Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females

Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females

Evaluation and Correlation between craniofacial bone densities and C1 and C2 cervical vertebrae using multislice computed tomography.

Assessment of bone density changes following two-jaw surgery using multidetector computed tomography: A pilot study

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