Population screening for congenital hypothyroidism.

Hulse, J A; Grant, D B; Clayton, Barbara E.; Lilly, P; Jackson, Doreen; Spracklan, A; Edwards, R. W. H.; Nurse, David S.

doi:10.1136/bmj.280.6215.675

Cited by 62 publications

(14 citation statements)

References 11 publications

(1 reference statement)

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“…Our recall rate due to raised thyroid stimulating hormone concentrations was similar to those found in other studies.7 221 Of the 31 babies recalled, 12 began thyroxine replacement treatment. The decision to treat was based on the thyroxine concentration together with clinical assessment.…”

Section: Discussionsupporting

confidence: 86%

Neonatal screening for congenital hypothyroidism by measurement of plasma thyroxine and thyroid stimulating hormone concentrations.

Griffiths¹,

Virdi²,

Rayner³

et al. 1985

BMJ

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Neonatal screening for congenital hypothyroidism was introduced in the City of Birmingham in 1980 by measuring concentrations of both thyroid stimulating hormone and thyroxine in plasma. Over two years 30108 babies were tested. Thirty one babies were recalled because of thyroid stimulating hormone concentrations greater than 40 mU/l, of whom 12 were treated with replacement thyroxine. Six babies were found to have low thyroxine concentrations because of reduced thyroxine binding globulin and five raised thyroxine values because of increased thyroxine binding globulin.As a result of this study screening was continued with measurement of thyroid stimulating hormone only as the primary test for congenital hypothyroidism, the thyroxine value being measured only when the concentration of thyroid stimulating hormone exceeded 20 mU/l.

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Section: Discussionsupporting

confidence: 86%

Neonatal screening for congenital hypothyroidism by measurement of plasma thyroxine and thyroid stimulating hormone concentrations.

Griffiths¹,

Virdi²,

Rayner³

et al. 1985

BMJ

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“…Genetic analysis of several hundred families has shown that the disease closely follows the pattern of autosomal recessive inheritance. 2 The clinical features of familial Mediterranean fever are not present in the newborn, but may appear as early as the first year of life. Over half of sufferers have had an attack by the age of 10 years, and 80-90% by the age of 20.…”

Section: Familial Mediterranean Fevermentioning

confidence: 99%

Screening for congenital hypothyroidism.

Kondo¹,

Hayashi²,

Yamashita³

1980

BMJ

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“…The status of such 'additional' babies and the optimum balance between screening sensitivity and specificity are still matters of debate. Hulse et al (1980), reporting on a pilot study of primary TSH screening in north London, attributed the discrepancy between their screening incidence of 1 in 3,363 births and the expected incidence of 1:6,000 to a greater number of mild cases. "Some of the babies with ectopic thyroid glands would probably have had compensated hypothyroidism for several months or years and would have been classified as cases of juvenile hypothyroidism.…”

mentioning

confidence: 95%