Population pharmacokinetics of topiramate in adult patients with epilepsy using nonlinear mixed effects modelling

Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data

“…For the CL/F, this value was moderately higher, but is comparable with the findings of previous studies. 10,19,20 For the Vd/F, this value is partly consistent with some previous studies, 12 but is higher compared to other studies. 3,21 The PK parameters of topiramate previously reported are summarized in Table 4.…”

“…however, the effects of phenobarbital on the CL/F of topiramate are controversial. 10,19 In our study, the CL/F of topiramate in patients receiving a co-administration with phenobarbital was the same as in patients with no inducers (Fig. 2).…”

“…4). Therefore, we recommend that the dose be 10,19,20 Apparent volume of distribution (Vd/F) 0.6-1.0 (L/kg) 3,21 Absorption rate constant (Ka) 2 (h -1 ) 10 Half-life (T 1/2 ) 20-30 (h) 1,8 Time to reach peak concentration (T max ) 1-4 (h) 3,21 Binding to blood protein 9-17 (%) 3,21…”

Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis

“…This is a little lower, but comparable with the findings of previous studies that reported topiramate CL/F to be between approximately 1.2 and a The number of patients who could be identified by their demographic and biochemical data. 1.8 L/h [8,11,12]. Our study population, which included patients with greater age, lower body weight, and lower daily doses compared with previous studies [8,11] might have influenced the lower clearance.…”

Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients

“…This might be due to varying magnitude of this interaction among patients [2,12]. Carbamazepine (CBZ) has a strong induction effect on both phases I and II metabolic enzymes and perhaps on Pglycoprotein function [13][14][15]. Based on current research results, CBZ effect on PB concentration is variable, and it differs between paediatric and adult patients, leading to contradictory data [12,16].…”