Population movements, borders, and Chagas disease

Avaria, Andrea; Ventura-Garcia, Laia; Sanmartino, Mariana; Laat, Carlos van der

doi:10.1590/0074-02760210151

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…The determinants and conditions that contribute to the transmission of trypanosomatid are uncontrolled human migration, unplanned urbanization with population concentration and socio-environmental and economic vulnerability. These conditions generate inequalities that, for infected populations, result in greater risk [34]. Consequently, there is low quality in the Primary Health Care (PHC) services provided, difficulty in diagnosing, not guaranteeing the integration of patient care, and failures in preventive interventions.…”

Section: Chagas Diseasementioning

confidence: 99%

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Neglected diseases in Brazil: space-temporal trends and public policies

Teresinha Schröder,

Fraga Da Silveira,

Thomasi Janhke Botton

et al. 2023

Neglected Tropical Diseases - Unsolved Debts for the One Health Approach

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In the twenty-first century, neglected tropical diseases still remain a serious public health problem, especially in developing countries. Meeting several sustainable development objectives of the 2030 Agenda, by countries that are in this condition, will provide the population with another level of quality of life. In Brazil, this situation is far from being resolved, since its dimensions are continental, there is a lot of social inequity, lack of basic services, health, and education. In this context, the scenario of the last 10 years of six neglected tropical diseases that are classified as notifiable in Brazilian territory is presented. There are several public policies established by the Federal government containing actions, strategies, and programs to try to reduce the burden of these diseases, but there is a lack of political will for states and municipalities to comply with the established in order to achieve all objectives and goals. It is still necessary to have an active participation of the population so that the reduction process can be started for possible elimination.

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Section: Chagas Diseasementioning

confidence: 99%

“…The territorialization of both information and professional performance can be allies in improving public health. The demarcation of areas of activity in the Health Units, in addition to the integration of actions and practices of integral reception of the care for the carrier of Chagas disease, is necessary [34].…”

Section: Chagas Diseasementioning

confidence: 99%

Neglected diseases in Brazil: space-temporal trends and public policies

Teresinha Schröder,

Fraga Da Silveira,

Thomasi Janhke Botton

et al. 2023

Neglected Tropical Diseases - Unsolved Debts for the One Health Approach

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“…Chagas disease has been included among the neglected diseases worldwide, with ∼6-7 million people globally affected, with 20-30% cardiomyopathy and death rates (2). Originally restricted to rural endemic Latin American areas, Chagas cases have been since reported in several urban areas of the Americas including Canada as well as the African, Eastern Mediterranean, European, and Western Pacific countries, associated with environmental changes and increased human mobility (3). In Latin America, established endemic areas have covered 21 countries, with ∼100 million exposed individuals (2).…”

Section: Introductionmentioning

confidence: 99%

Serosurvey of Trypanosoma cruzi in persons experiencing homelessness and shelter workers of Brazil

Kmetiuk

Gonçalves

Couto

et al. 2023

Front. Public Health

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Although Chagas disease, caused by Trypanosoma cruzi, has been associated with social vulnerability worldwide, producing disability and mortality, no study to date has assessed this protozoal infection in persons experiencing homelessness. Accordingly, the present study aimed to assess anti-T. cruzi antibodies by Wiener Chagatest ELISA recombinant v.3.0 in serum samples of persons experiencing homelessness and related shelter workers in São Paulo, a city with reported vectors but no recent autochthonous case report. Overall, seropositivity to T. cruzi resulted in three of 203 (1.5%) persons experiencing homelessness and two of 87 (2.3%) shelter workers, with similar seroprevalence likely associated with their past social vulnerability. Although the seropositivity in persons experiencing homelessness and shelter workers was within 0 to 25.1% seroprevalence for chronic Chagas disease in the general Brazilian population, the disease has almost decreased 2-fold from the 1980s to 2000s, and such a wide range may not reflect the local disease status. In addition, the authors hypothesized that the similar seroprevalence and exposure between homeless persons and shelter workers herein may be more associated with shared past and present low-income social vulnerability than migratory movements, which may also include infection by sharing injecting drugs, vertical transmission, or blood transfusion. Thus, future studies are needed to confirm the active transmission of Chagas disease in São Paulo city. Moreover, Chagas disease should be considered as differential diagnosis in homeless persons and shelter workers, even in major disease-free Brazilian or other worldwide cities, mostly due to early exposure and vulnerable living conditions.

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“…A concerning public health issue, Chagas disease, also known as American Trypanosomiasis, is a neglected tropical disease (NTD) caused by the protozoan parasite Trypanosoma cruzi [ 1 ]. Although primarily found in Latin America, where it is endemic in 21 countries, cases have also been reported to other regions due to migration and international travel [ 2 , 3 , 4 ]. According to the World Health Organization (WHO), there are currently around eight million people infected worldwide [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Trypanosoma cruzi Activity of Chemical Constituents from Baccharis sphenophylla Isolated Using High-Performance Countercurrent Chromatography

Silva,

Sales,

Levatti

et al. 2023

Molecules

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Endemic in 21 countries, Chagas disease, also known as American Trypanosomiasis, is a neglected tropical disease (NTD) caused by the protozoan parasite Trypanosoma cruzi. The available drugs for the treatment of this disease, benznidazole and nifurtimox, are outdated and display severe side effects. Thus, the discovery of new drugs is crucial. Based on our continuous studies aiming towards the discovery of natural products with anti-T. cruzi potential, the MeOH extract from aerial parts of Baccharis sphenophylla Dusén ex. Malme (Asteraceae) displayed activity against this parasite and was subjected to high-performance countercurrent chromatography (HPCCC), to obtain one unreported syn-labdane diterpene — sphenophyllol (1) — as well as the known compounds gaudichaudol C (2), ent-kaurenoic acid (3), hispidulin (4), eupafolin (5), and one mixture of di-O-caffeoylquinic acids (6–8). Compounds 1–8 were characterized by analysis of nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. When tested against trypomastigote forms, isolated labdane diterpenes 1 and 2 displayed potent activity, with EC50 values of 20.1 μM and 2.9 μM, respectively. The mixture of chlorogenic acids 6–8, as well as the isolated flavones 4 and 5, showed significant activity against the clinically relevant amastigotes, with EC50 values of 24.9, 12.8, and 2.7 μM, respectively. Nonetheless, tested compounds 1–8 displayed no cytotoxicity against mammalian cells (CC50 > 200 μM). These results demonstrate the application of HPCCC as an important tool to isolate bioactive compounds from natural sources, including the antitrypanosomal extract from B. sphenophylla, allowing for the development of novel strategic molecular prototypes against tropical neglected diseases.

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Population movements, borders, and Chagas disease

Cited by 10 publications

References 34 publications

Neglected diseases in Brazil: space-temporal trends and public policies

Neglected diseases in Brazil: space-temporal trends and public policies

Serosurvey of Trypanosoma cruzi in persons experiencing homelessness and shelter workers of Brazil

Evaluation of Anti-Trypanosoma cruzi Activity of Chemical Constituents from Baccharis sphenophylla Isolated Using High-Performance Countercurrent Chromatography

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