Population Genetics of GYPB and Association Study between GYPB*S/s Polymorphism and Susceptibility to P. falciparum Infection in the Brazilian Amazon

Tarazona‐Santos, Eduardo; Castilho, Lilian; Amaral, Daphne Renata Tavares; Costa, Daiane Cobianchi da; Furlani, Natália G.; Zuccherato, Luciana W.; Machado, Moara; Reid, Marion E.; Zalis, Mariano Gustavo; Rossit, Andréa Regina Baptista; Santos, Sidney Emanuel Batista dos; Machado, Ricardo Luiz Dantas; Lustigman, Sara

doi:10.1371/journal.pone.0016123

Cited by 31 publications

(39 citation statements)

References 82 publications

(88 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is assumed that the polymorphicity of erythrocyte surface structures in mammals has been the driving force for this remarkable sequence dispersion (316), especially since the different copies of Trw surface proteins seem to be coexpressed (115). Such host polymorphisms have also been proposed to affect red blood cell invasion of Plasmodium parasites (289,414,437), but it remains unknown which host factors the Trw T4SS binds on the erythrocyte surface.…”

Section: Infection Of Erythrocytesmentioning

confidence: 99%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

View full text Add to dashboard Cite

SUMMARY Bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. Infections with Bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. Upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted to involve the manipulation of nucleated host cells, e.g., in the microvasculature. Consistently, in vitro research showed that Bartonella harbors an ample arsenal of virulence factors to modulate the response of such cells, gain entrance, and establish an intracellular niche. Subsequently, the bacteria are seeded into the bloodstream where they invade erythrocytes and give rise to a typically asymptomatic intraerythrocytic bacteremia. While this course of infection is characteristic for natural hosts, zoonotic infections or the infection of immunocompromised patients may alter the path of Bartonella and result in considerable morbidity. In this review we compile current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella and discuss their connection to the clinical presentation of human patients, which ranges from minor complaints to life-threatening disease.

show abstract

Section: Infection Of Erythrocytesmentioning

confidence: 99%

Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

2012

View full text Add to dashboard Cite

show abstract

“…This panel was previously used by Santos et al (2010) and has been successfully used to assess parental genetic contribution in different populations (Ota et al 2010;Tarazona-Santos et al 2011).…”

Section: Afro-derived Amazonianmentioning

confidence: 99%

Afro-Derived Amazonian Populations: Inferring Continental Ancestry and Population Substructure

et al. 2011

View full text Add to dashboard Cite

A panel of Ancestry Informative Markers (AIMs) was used to identify population substructure and estimate individual and overall interethnic admixture in 294 individuals from seven African-derived communities of the Brazilian Amazon. A panel of 48 biallelic markers, representing the insertion (IN) or the deletion (DEL) of small DNA fragments, was employed for this purpose. Overall interethnic admixture estimates showed high miscegenation with other ethnic groups in all populations (between 46% and 64%). The proportion of ancestral genes varied significantly among individuals of the sample: the contribution of African genes varied between 12% and 75%; of European genes between 10% and 73%; and of Amerindians genes between 8% and 66%. The obtained data reveal a high contribution of Amerindian genes in these communities, unlike in other African-derived communities of the Northeast and the South of Brazil. In addition, the majority of the Amerindian contribution may result from the preferential inclusion of indigenous women in the African descent groups. High heterogeneity of the proportion of interethnic admixture among analyzed individuals was found when the proportion of ancestral genes of each individual of the sample was estimated. This heterogeneity is reflected in the fact that four populations can be considered as substructured and that the global African descent sample is possibly formed by two subpopulations. 46% and 64%). The proportion of ancestral genes varied significantly among individuals of the sample: the contribution of African genes varied between 12% and 75%; of European genes between 10% and 73%; and of Amerindians genes between 8% and 66%. The obtained data reveal a high contribution of Amerindian genes in these communities, unlike in other African-derived communities of the Northeast and the South of Brazil. In addition, the majority of the Amerindian contribution may result from the preferential inclusion of indigenous women in the African descent groups. High heterogeneity of the proportion of interethnic admixture among analyzed individuals was found when the proportion of ancestral genes of each individual of the sample was estimated. This heterogeneity is reflected in the fact that four populations can be considered as substructured and that the global African descent sample is possibly formed by two subpopulations. Keywords AMAZON, AIM, AFRICAN DESCENT, INDEL, POPULATION SUBSTRUCTUREThe Brazilian population is the product of the miscegenation of three main ethnic groups: Amerindians, Europeans, and Africans. It is estimated that approximately four million Africans were brought by force to Brazil as slaves between 1550 and 1870 (Klein 1986). The distinct geographical regions of Brazil received different numbers of African slaves, being greater in the Northeast and lower in the North (Santos and Guerreiro 1995). The arrival of African slaves to the Amazon began in the mid-17th century (1750). It is estimated that at least 53,000 Africans arrived in the Brazilian Amazon during the ...

show abstract

“…The method of genomic control employed in this study has been used successfully in other publications by this research group. 24,[29][30][31][32][33] The results from the multivariate statistical model used to determine the association between the CYP3A5 gene A6986G polymorphism and the drugs examined did not differ between the patients with and without hepatotoxicity (p = 0.176; OR 0.562, 95% CI 0.255-1.238). The CYP3A5 gene polymorphism results are consistent with data published previously for other populations, because no association was observed between the A6986G polymorphism and drug-induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 94%