Population Burden of Betel Quid Abuse and Its Relation to Oral Premalignant Disorders in South, Southeast, and East Asia: An Asian Betel-Quid Consortium Study

Lee, Chien-Hung; Ko, Albert Min-Shan; Warnakulasuriya, Saman; Ling, Tianyou; Sunarjo,; Rajapakse, Palandage Sunethra; Zain, Rosnah Binti; Ibrahim, Mohamed Yousif; Zhang, Shanshan; Wu, Hanjiang; Liu, Lin; Kuntoro,; Utomo, Budi; Warusavithana, Supun Amila; Razak, Ishak Abdul; Abdullah, Nurliza; Shrestha, Pragya; Shieh, Tien-Yu; Yen, Cheng‐Fang; Ko, Ying‐Chin

doi:10.2105/ajph.2011.300521

Cited by 58 publications

(55 citation statements)

References 34 publications

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“…In addition, our results were consistent with the fact that betel quid abuse 16 1 was frequent in these areas, and the incidence of oral premalignancies was also much higher than in other places. 39 This study had some limitations. First, it is possible that some studies that were not included in the current analysis would have affected the results.…”

Section: Discussionmentioning

confidence: 92%

Betel Quid Chewing Without Tobacco

Song

Wan

2013

Asia Pac J Public Health

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Betel quid without tobacco is an important factor influencing the incidences of oral cancer and precancer. This study systematically evaluated the associations between betel quid containing no tobacco and oral cancer and precancer, with implications for the prevention of oral cancer. We searched MEDLINE, ISI Web of Science, and EMBASE (to April 2011) and retrieved studies that investigated the relationship between chewing betel quid and oral cancer (or precancer). We performed a meta-analysis to summarize the published data and describe the prevalence of betel quid use with regard to cancerous diseases. In all, 19 eligible studies that reported odds ratios and 95% confidence intervals for oral cancer with respect to betel quid were included. The analysis identified an association suggesting that betel quid might be an important risk factor for oral cancer and precancer. The results of this review suggest that betel-chewing-cessation programs should be developed to help prevent oral diseases.

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Section: Discussionmentioning

confidence: 92%

Betel Quid Chewing Without Tobacco

Song

Wan

2013

Asia Pac J Public Health

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“…During the same year, approximately 8400 OSCC patients died as a consequence of complications from the disease [1,2]. Main risk factors for OSCC development in western countries include heavy tobacco use combined with excessive alcohol consumption, whereas in south and southeast Asia, OSCC is most commonly associated with betel and areca nut chewing [3,4]. In spite of an overall decline in tobacco consumption, the recent rise in head and neck cancer cases linked to oncogenic subtypes of human papillomaviruses (HPV) is becoming a growing public health concern.…”

Section: Introductionmentioning

confidence: 99%

Advances in the Chemopreventive Targeting of Oral Carcinogenesis

Wisniewski

Schneider

2015

Curr Oral Health Rep

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Control of oral cancer associated with the frequent exposure to traditional risk factors such as tobacco, betel quid, and alcohol, together with the recent rise in human papillomavirus-related oropharyngeal cancer is a major public health concern worldwide. Late diagnosis and Bfield cancerization,^where multifocal malignant lesions compromise standard surgical treatments and chemoradiotherapy are among the most critical challenges faced by clinical oncologists. In addition to improving methods of early diagnosis and periodic monitoring, halting tumor progression through longterm chemoprevention of at risk premalignant lesions with well-tolerated drugs or natural products remains an attractive strategy. This review discusses recent progress and challenges on the chemopreventive targeting of oral cancer, especially as it relates to the genomic and molecular characterization of oncogenic drivers underlying tumor development and progression. These emerging data may ultimately serve as the basis for novel early and predictable interventions to significantly reduce morbidity and mortality associated with oral cancer.

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“…This research series has awakened the problems and challenges posed by BQ use [25][26][27]. For this study, we focused on the issues of (1) evaluating the symptoms and syndrome of BQ-D among chewers who consumed various types of BQ products in six Asian populations using DSM-IV and ICD-10 criteria for substance use disorder [28,29], and (2) investigating chewer-related factors accounting for country-specific BQ-D.…”

Section: Introductionmentioning

confidence: 99%