Betel Quid Chewing Without Tobacco

Song, Han; Wan, Yi; Xu, Yiming

doi:10.1177/1010539513486921

Cited by 36 publications

(11 citation statements)

References 37 publications

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“…The findings showed that the highest incidence of LOCC, overall and by sex, was found in countries in Oceania and Asia, countries with a history of high tobacco use in its various forms. Similar results have been reported previously, southeast Asian countries have a higher incidence of LOCC and a correlation with the geographical distribution of betel nut [ 28 ], which is considered a major risk factor for the development of potentially malignant lesions and oral cancers [ 29 ]. It is necessary, however, to undertake future studies to further delineate such phenomena.…”

Section: Discussionsupporting

confidence: 89%

Lip and Oral Cavity Cancer Incidence and Mortality Rates Associated with Smoking and Chewing Tobacco Use and the Human Development Index in 172 Countries Worldwide: An Ecological Study 2019–2020

et al. 2023

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Tobacco use is associated with diseases worldwide, including cancer. This is one of the major public health problems globally, causing more than 19 million new cases in 2020. Lip and oral cavity cancer (LOCC) is neoplastic growth in the tongue, gums, and lips. The objective of this ecological study was to quantify the strength of the association between incidence and mortality of LOCC, with tobacco use and with the Human Development Index (HDI). Incidence and mortality data on LOCC were obtained for 172 countries in 2020, from the Global Cancer Observatory (GLOBOCAN). The prevalence of tobacco smoking and chewing was obtained from reports conducted in 2019. The inequality in human development was estimated using the HDI from the United Nations Development Program, Human Development Report (2019). Statistically significant correlations were observed between the incidence of LOCC and tobacco smoking and chewing prevalence, except for negative correlations between the prevalence of tobacco smoking LOCC mortality in women, just as in the case of the HDI. No statistically significant differences were found between the prevalence of tobacco chewing only and the incidence of LOCC overall and by sex. A higher LOCC incidence overall and by sex was associated with higher HDI. In conclusion, the present study found positive correlations for various HDI socioeconomic indicators and tobacco use with the incidence and mortality of LOCC, but also a few inverse correlations.

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Section: Discussionsupporting

confidence: 89%

Lip and Oral Cavity Cancer Incidence and Mortality Rates Associated with Smoking and Chewing Tobacco Use and the Human Development Index in 172 Countries Worldwide: An Ecological Study 2019–2020

et al. 2023

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“…Betel quid has been considered a carcinogen by the International Agency for Research on Cancer (IARC) for several years [ 27 ]. Previous results have shown that betel quid chewing has a significant negative effect on oral cancer and precancer [ 28 ]. Longer duration and higher frequency of betel quid chewing have been found to increase the risk of oral cancer [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Favorable Lip and Oral Cancer Mortality-to-Incidence Ratios in Countries with High Human Development Index and Expenditures on Health

Sung

Hsu

Chen

et al. 2021

IJERPH

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Background: The incidence rates of lip and oral cancer have continued to increase, and prognosis is associated with a country’s socioeconomic status. The mortality-to-incidence ratio (MIR) is a reasonable indicator of disparities in cancer screening and treatment. In this study, we aimed to understand the association between economic status and cancer prognosis. Methods: Data were obtained from the Global Cancer Observatory (GLOBOCAN) and the World Health Organization (WHO). The MIRs were compared to evaluate the correlation with the human development index (HDI), the current health expenditure (CHE), and the ratio of CHE over gross domestic product (CHE/GDP) disparities via Spearman’s rank correlation coefficient. Results: The results showed that Asia had the most cases and deaths. In addition, they showed a significant association (p < 0.001, p = 0.005, and p < 0.001, respectively) of the crude rate (CR) of incidence with the HDI, the CHE, and the CHE/GDP. However, their associations with mortality rate (p = 0.303, p = 0.997, and p = 0.101) were not significant. Regarding the correlation of the MIRs, the results revealed a significant association with the HDI, the CHE, and the CHE/GDP (p < 0.001, p < 0.001, and p < 0.001, respectively). Conclusion: Countries with higher HDI, CHE per capita, and CHE/GDP tend to have lower MIRs, which indicates favorable clinical outcomes.

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“…Oral cancer development is increased by a number of lifestyle choices including tobacco [8, 9] and alcohol use [10]. Particularly in Asia, betel quid (or paan) chewing (with or without tobacco [11, 12]) increases rates of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF) [13–21]. Betel quid (typically consisting of betel leaf, areca nut, slaked lime, and possibly tobacco [22]) was identified as a contributer to increased oral cancer incidence as early as 1902 [23].…”

Section: Introductionmentioning

confidence: 99%

Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities

et al. 2018

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Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity with the potential to reduce morbidity, mortality, and overall healthcare costs. Using a custom Android application, this device synchronizes external light-emitting diode (LED) illumination and image capture for AFI and WLI. Data is uploaded to a cloud server for diagnosis by a remote specialist through a web app, with the ability to transmit triage instructions back to the device and patient. Finally, with the on-site specialist’s diagnosis as the gold-standard, the remote specialist and a convolutional neural network (CNN) were able to classify 170 image pairs into ‘suspicious’ and ‘not suspicious’ with sensitivities, specificities, positive predictive values, and negative predictive values ranging from 81.25% to 94.94%.

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Betel Quid Chewing Without Tobacco

Cited by 36 publications

References 37 publications

Lip and Oral Cavity Cancer Incidence and Mortality Rates Associated with Smoking and Chewing Tobacco Use and the Human Development Index in 172 Countries Worldwide: An Ecological Study 2019–2020

Lip and Oral Cavity Cancer Incidence and Mortality Rates Associated with Smoking and Chewing Tobacco Use and the Human Development Index in 172 Countries Worldwide: An Ecological Study 2019–2020

Favorable Lip and Oral Cancer Mortality-to-Incidence Ratios in Countries with High Human Development Index and Expenditures on Health

Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities

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