Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromso study

Jorde, Rolf; Kh, Bønaa; Sundsfjord, Johan

doi:10.1530/eje.0.1410350

Cited by 54 publications

(64 citation statements)

References 38 publications

(36 reference statements)

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“…However, they did not adjust for serum calcium, and in the multivariate analysis age lost its significance as an explanatory variable for PTH. In our study, age was the most significant explanatory variable for serum PTH, which is in accordance with another population-based epidemiological study (19). Lind et al (18) studied 143 hypertensive and 51 normotensive subjects and measured serum PTH in a random subgroup of 76 subjects.…”

Section: Discussionsupporting

confidence: 91%

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Kamycheva

Sundsfjord

Jorde

2004

European Journal of Endocrinology

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175

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Objective: To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. Design: Population based, cross-sectional study. Methods:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical history and life-style factors were completed and anthropometric data were collected. Calcium and vitamin D intakes and a physical activity score were calculated. Serum calcium and PTH were measured in a subset of 3447 men and 4507 women. Pearson correlation and linear regression were used to evaluate associations between BMI, PTH and serum calcium, and logistic regression was used to test PTH and serum calcium as predictors of obesity and to calculate odds ratio. Relative risk was calculated using frequency tables. Results: For serum calcium and PTH there was a significant positive relation to BMI in both genders (P , 0.001), which to our knowledge has not previously been reported on the basis of a large epidemiological study. Age, low calcium and vitamin D intakes were explanatory variables for serum PTH. The highest quartile of serum PTH (.4.20 pmol/l) was a significant predictor for obesity (P , 0.001) in both genders, adjusted for age, physical activity and serum calcium. Obesity rates were higher in those with PTH levels in the highest quartile compared with those in the lower quartiles, which resulted in a relative risk of 1.40 (95% confidence interval (C.I.) 1.20 -1.60) for men and 1.48 (95% C.I. 1.31 -1.67) for women. Conclusions: Serum PTH, adjusted for age, physical activity and serum calcium, is positively associated with BMI in both sexes, and serum PTH is an independent predictor of obesity in our statistical model.

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Section: Discussionsupporting

confidence: 91%

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Kamycheva

Sundsfjord

Jorde

2004

European Journal of Endocrinology

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175

103

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“…Cases with mild pHPT also have an increased risk of morbidity and mortality of the cardiovascular system (3,(33)(34)(35). Several populationbased studies and investigations with patients recruited consecutively have confirmed the association between pHPT and cardiovascular diseases, where both calcium and PTH are associated directly or indirectly with increased morbidity and mortality (2,(36)(37)(38). Moreover, in population-based studies, calcium per se, in the normal range without associated disturbances in serum PTH, also has a positive association with hard endpoints such as myocardial infarction (39,40).…”

Section: Discussionmentioning

confidence: 98%

Metabolic abnormalities in patients with normocalcemic hyperparathyroidism detected at a population-based screening

et al. 2006

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Objective: Dyslipidemia, hypertension, diabetes mellitus and also primary hyperparathyroidism (pHPT) are associated with an increased risk of cardiovascular diseases. Metabolic abnormalities in mild pHPT have been reported, but never in cases with normal calcium and high parathyroid hormone (PTH) levels, i.e. suffering from 'normocalcemic pHPT'. Our aim was to explore the occurrence of these metabolic abnormalities in individuals with normocalcemic pHPT identified in a population-based screening, and the effects of parathyroidectomy vs conservative treatment on metabolic variables. Design and methods: A population-based screening of 5202 post-menopausal women identified 30 patients with normal calcium, inappropriately high PTH and normal creatinine. A 5-year follow-up included 15 parathyroidectomized (PTx) and nine conservatively followed cases, in a non-randomized setting, together with age-matched controls. Biochemical variables and body mass index (BMI) were investigated. Results: At study entry, cases had higher calcium, PTH, glucose, low-density lipoprotein (LDL)/highdensity lipoprotein (HDL)-cholesterol, very low-density lipoprotein (VLDL)-cholesterol, total triglycerides, and BMI compared to controls (PZ!0.0001-0.035). The cases had a lower HDL-cholesterol value (PZ0.013) and one third of the cases had hypertriglyceridemia. During follow-up, the PTx cases decreased in calcium, PTH, LDL/HDL-cholesterol, total and LDL-cholesterol (PZ0.0076-0.022). Investigated biochemical variables remained adverse in conservatively followed cases during follow-up except a decreased LDL-cholesterol value. All surgically treated patients had parathyroid adenoma. Conclusions: Cases with normocalcemic pHPT have increased proatherogenic lipoprotein levels, BMI and glucose levels compared to age-matched controls. Parathyroidectomy has positive effects on some of these variables and reverses them to the same level as the controls, while conservative treatment fails to normalize the investigated metabolic variables.

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“…9 All men and women older than 29 years, living in the municipality of Tromsø and that participated in the second phase of the fourth Tromsø study 10 or became 30, 40, 45, 60 or 75 years old during 2001, were invited to participate. All subjects filled in a health questionnaire including smoking status, use of thyroxine and blood pressure lowering medication.…”

Section: Methodsmentioning

confidence: 99%

“…Height, weight and blood pressure were measured as described previously. 10 Body mass index (BMI) was calculated as weight (kg) divided by squared height (m 2 ). Non-fasting blood samples were drawn between 0800 and 1600 h, and analyzed for serum TSH as described previously (reference range 0.20-4.00 mIU/l).…”

Section: Methodsmentioning

confidence: 99%

Blood pressure in relation to serum thyrotropin: the Tromsø study

2006

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It appears to be an association between hypothyroidism and hypertension. However, the relation between thyroid function and blood pressure within the normal serum thyrotropin (TSH) range is uncertain. In the fifth Tromsø study, which is a population-based health survey, serum TSH and blood pressure were measured. This gave us the opportunity to test the hypothesis of a relation between serum TSH and blood pressure within the normal serum TSH range. In all 5872 subjects (2623 male subjects) not using blood pressure or thyroxine medication were included in the present study. Within the normal serum TSH range (0.20-4.00 mIU/l), there was a significant and positive relation between serum TSH and both systolic and diastolic blood pressure. Within this range, and adjusted for age, body mass index and smoking status, the systolic blood pressure was 1.4 mm Hg and the diastolic 1.6 mm Hg higher in male subjects in the highest versus those in the lowest serum TSH quartile. The corresponding differences in the female subjects were 4.0 and 2.7 mm Hg, respectively. When dividing this cohort in those with systolic (4160 mm Hg) and diastolic (495 mm Hg) hypertension, serum TSH was higher in the hypertensive subjects, but the differences were only statistically significant for diastolic hypertension (serum TSH 1.8870.82 versus 1.6970.74 mIU/l for male subjects, and 1.7970.78 versus 1.6370.75 mIU/l for female subjects, Po0.05). In conclusion, there is a modest, but significant positive association between serum TSH and blood pressure within the normal serum TSH range.

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Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromso study

Cited by 54 publications

References 38 publications

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Metabolic abnormalities in patients with normocalcemic hyperparathyroidism detected at a population-based screening

Blood pressure in relation to serum thyrotropin: the Tromsø study

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