Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Kamycheva, Elena; Sundsfjord, Johan; Jorde, Rolf

doi:10.1530/eje.0.1510167

Cited by 174 publications

(124 citation statements)

References 32 publications

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“…3,4 In addition, Kamycheva et al 23 recently demonstrated that serum levels of PTH are positively correlated with BMI in a large crosssectional study (n ¼ 7954). In this study, the relative risk of obesity was greater for those in the highest quartile of serum PTH values, independent of gender.…”

Section: Discussionmentioning

confidence: 97%

Parathyroid hormone is associated with decreased fat mass in young healthy women

et al. 2005

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Objective: To investigate the relationship of parathyroid hormone (PTH) with dietary calcium and changes in body composition. Design: Cross-sectional and 1-year longitudinal trial. Subjects: Normal-weight young women (age: 18-31), 155 subjects analyzed at baseline, and data for 41 subjects analyzed prospectively between baseline and 12 months. Measurements: Levels of fasting serum calcium and PTH, intakes of calcium (3-day diet records), and total body weight and body composition (dual energy X-ray absorptiometry). Results: Baseline dietary calcium, regardless of whether unadjusted or adjusted for energy intake, did not predict baseline levels of fasting serum PTH. Change in dietary calcium also did not predict change in serum PTH. However, log PTH was significantly correlated with body fat mass (R ¼ 0.27), but not lean mass at baseline (n ¼ 155), independent of serum calcium (corrected R ¼ 0.25). Further, 12-month changes (n ¼ 41) in log PTH positively predicted the 12-month change in body weight (R ¼ 0.32) and body fat (R ¼ 0.32), but not lean mass even when controlled for age or change in serum calcium. Conclusion: Fasting serum PTH was associated with increased fat mass, in both cross-sectional and prospective analysis. Thus, serum PTH may play a role in the regulation of body fat mass in young women.

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Section: Discussionmentioning

confidence: 97%

Parathyroid hormone is associated with decreased fat mass in young healthy women

et al. 2005

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“…Obesity has been found to be associated with lower levels of serum 25-OH Vit D (1-5) and higher levels of serum PTH (1,(5)(6)(7)(8). A low vitamin D intake was associated with increased body mass index (BMI) (9).…”

Section: European Journal Of Endocrinology 157 225-232mentioning

confidence: 99%

“…A low vitamin D intake was associated with increased body mass index (BMI) (9). PTH has been postulated as an independent predictor of obesity (7). Overweight as a consequence of elevated serum PTH was explained by several mechanisms (10,11): PTH stimulates the renal hydroxylation of 25-OH Vit D to its active form, 1,25-OH Vit D, which in turn elevates the calcium influx into adipocytes.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Reinehr¹,

Sousa²,

Alexy³

et al. 2007

eur j endocrinol

181

114

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Objective: The roles of vitamin D and parathyroid hormone (PTH) are discussed controversially in obesity, and studies of these hormones in obese children are limited. Therefore, we studied the relationships between PTH, 1,25-dihydroxy-vitamin D (1,25-OH Vit D), 25-hydroxy-vitamin D (25-OH Vit D), weight status, and insulin sensitivity before and after weight loss in obese children. Methods: Fasting serum PTH, 1,25-OH Vit D, 25-OH Vit D, inorganic phosphate, calcium, alkaline phosphatase (AP), insulin, glucose, and weight status (SDS-BMI and percentage body fat) were determined in 133 obese children (median age 12.1 years) and compared with 23 non-obese children. Furthermore, these parameters were analyzed in 67 obese children before and after participating in a 1-year obesity intervention program. Results: Obese children had significantly (P!0.001) higher PTH and lower 25-OH Vit D concentrations compared with non-obese children, while calcium, phosphate, AP, and 1,25-OH Vit D did not differ significantly. Changes of PTH (rZ0.23, PZ0.031) and 25-OH Vit D (rZK0.27, PZ0.013) correlated significantly with changes of SDS-BMI, but not with changes of insulin sensitivity (homeostasis model assessment; HOMA-B%). Reduction of overweight in 35 children led to a significant (P!0.01) decrease of PTH concentrations and an increase in 25-OH Vit D levels. Conclusions: PTH levels were positively and 25-OH Vit D concentrations were negatively related to weight status. Since these alterations normalized after weight loss, these changes are consequences rather than causes of overweight. A relationship between PTH, vitamin D, and insulin sensitivity based on the HOMA index was not found in obese children. Further longitudinal clamp studies are neccessary to study the relationship between vitamin D and insulin sensitivity. European Journal of Endocrinology 157 225-232Introduction Vitamin D and parathyroid hormone (PTH) are well known for their essential role in bone metabolism and calcium homeostasis. The main sources of vitamin D are ergocalciferol and cholecalciferol, the former normally available in food and the latter produced in the skin by u.v. radiation of 7-dehydrocholesterol. Both of these compounds are hydroxylated in the liver to 25-hydroxyvitamin D (25-OH Vit D), which is the major circulating metabolite precursor to the hormonally active form, 1,25-dihydroxy-vitamin D (1,25-OH Vit D).It has become increasingly clear that the vitamin D endocrine system is related to obesity in adults. Obesity has been found to be associated with lower levels of serum 25-OH Vit D (1-5) and higher levels of serum PTH (1,(5)(6)(7)(8). A low vitamin D intake was associated with increased body mass index (BMI) (9). PTH has been postulated as an independent predictor of obesity (7). Overweight as a consequence of elevated serum PTH was explained by several mechanisms (10, 11): PTH stimulates the renal hydroxylation of 25-OH Vit D to its active form, 1,25-OH Vit D, which in turn elevates the calcium influx into adipocytes. In these cell...

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“…It is possible that adiposity or related metabolic abnormalities stimulate PTH production. A number of studies have reported associations between PTH and adiposity, 5,18 as well as other cardiovascular risk factors and mortality. 19,20 Individuals with normocalcemic hyperparathyroidism have been shown to have increased BMI, triglycerides, LDL cholesterol and blood glucose.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone reflects adiposity and cardiometabolic indices but not bone density in normal men

2016

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Hyperparathyroidism may be associated with skeletal and cardiovascular abnormalities, but it is unclear whether these associations exist for high-normal levels of parathyroid hormone (PTH). We assessed relationships between PTH and anthropometric, skeletal and cardiometabolic indices in normal men. Body composition, blood pressure, biochemistry and bone mineral density (BMD) were evaluated in 151 healthy men. BMD was reassessed at 2 years, and coronary artery calcium (CAC) was measured at 3.5 years. Relationships between PTH and other baseline characteristics, CAC scores and change in BMD were evaluated. PTH correlated positively with baseline body mass index, fat mass, diastolic blood pressure, triglycerides, total and low-density lipoprotein (LDL) cholesterol, (r ¼ 0.19-0.25, P ¼ 0.02-0.002), and with category of CAC score. Relationships between PTH and cardiometabolic indices remained significant after adjustment for age, 25-hydroxyvitamin D and estimated glomerular filteration rate. Men in the top PTH tertile (X4.4 pmol l À 1 , n ¼ 51) were more likely to have LDL cholesterol X3.5 mmol l À 1 , diastolic blood pressure X85 mm Hg, and CAC score 40 than men in lower tertiles. PTH was not associated with history of fracture, baseline BMD, or change in BMD over 2 years. In summary, in this cohort of healthy men, PTH levels are linearly related to adiposity and to cardiometabolic indices, but not to BMD or bone loss. These findings suggest that adiposity should be considered as an independent cause of secondary hyperparathyroidism, and they may be relevant to patients with normocalcemic hyperparathyroidism, in whom high PTH levels may be a marker of adiposity and cardiometabolic risk rather than always indicating parathyroid autonomy.

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Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Cited by 174 publications

References 32 publications

Parathyroid hormone is associated with decreased fat mass in young healthy women

Parathyroid hormone is associated with decreased fat mass in young healthy women

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Parathyroid hormone reflects adiposity and cardiometabolic indices but not bone density in normal men

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