Population-based risk factors and resource utilization for HCC: US perspective

Sanyal, Arun J.; Poklepovic, Andrew; Moyneur, Érick; Barghout, Victoria

doi:10.1185/03007995.2010.506375

Cited by 271 publications

(230 citation statements)

References 12 publications

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“…The health burden of NAFLD is mostly related to the risk of its progression into cirrhosis, liver failure and hepatocellular carcinoma [3] . It is also associated with a large amount of heath care cost [4] .…”

Section: Introductionmentioning

confidence: 99%

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

Ghamar-Chehreh

Amini

Khedmat

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

Ghamar-Chehreh

Amini

Khedmat

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…A number of large registry or cohort studies have subsequently confirmed these observations in the United States (3,4), Europe (5) and the Asia Pacific (6,7). The increasing prevalence of obesity worldwide underpins this global pattern of change, with the predicted higher prevalence of NAFLD in coming years a cause for major concern (8).…”

mentioning

confidence: 74%

NAFLD—which patients should have hepatocellular carcinoma surveillance?

Elcioglu¹,

Reeves²

2017

Hepatobiliary Surg. Nutr.

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“…This study identified an existing gap between screening and treatment guidelines and practice patterns, implying a need for greater health care provider awareness and education. 25 In another study, approximately 48% of patients were seen by a gastroenterologist/hepatologist or by a physician with an academic affiliation. Patients were approximately 4.5-fold and 2.8-fold, respectively, more likely to receive regular surveillance than those seen by a primary care physician only.…”

Section: Current Level Of Awareness About Hepatocellular Carcinoma Sumentioning

confidence: 99%

Role of Surveillance in Prevention of Hepatocellular Carcinoma

Panda

2014

Journal of Clinical and Experimental Hepatology

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Hepatocellular carcinoma is a common malignancy and one of the important public health problems in India. The surveillance of hepatocellular carcinoma (HCC) is an established approach to detect early cancers in patients with defined risks. However, there are still controversies and issues to be addressed regarding the optimal surveillance methods and interval. The current level of awareness among physicians in India about surveillance is low and the need and most cost effective surveillance strategy in developing country like ours is unclear. This article has tried to discuss these issues in their appropriate perspective. To address this complicated issue, a multicenter randomized prospective study however may be required. ( J CLIN EXP HEPATOL 2014;4:S43-S49) H epatocellular carcinoma (HCC) is the fifth commonest cancer worldwide and third commonest cause of cancer related mortality. 1 In India, the mean incidence of HCC as per four population-based registries was 2.77% for males and 1.38% for females. The prevalence of HCC in India varies from 0.2% to 1.6%. 2,3 It is interesting to note that the consolidated data from cancer registries of India do not reflect HCC as an important malignancy. 4 Risk of HCC development is high in patients with liver cirrhosis of any etiology, particularly with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. 5 Since India has a high prevalence of HBV infection (4% of population, i.e about 40 million Indians) 6 as well as HCV infection (0.3-1.5%) it could contribute to the high incidence of HCC. 7 Other risk factors for HCC like high prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) obesity, diabetes, alcohol consumption among males are also present in India.Nonalcoholic Fatty Liver Disease (NAFLD) particularly its more aggressive form, nonalcoholic steatohepatitis (NASH) is an important factor which can lead to cirrhosis and HCC. It is estimated that nearly two-thirds of obese people have some form of fatty liver, ranging from steatosis to NASH. NASH can progress to liver cirrhosis in 3%-15% and subsequently to liver cancer. 8 A study by Prasad et al showed that age-standardized prevalence rates of metabolic syndrome were 33.5% overall, 24.9% in males and 42.3% in females in India. Authors concluded that metabolic syndrome is a significant public health problem even in one of the poorest states of India. 9 Hence NASH is particularly important in countries like India where metabolic syndrome is on the rise.It is important to note that in the absence of an effective screening program and only 7% of population being covered by cancer registries, under reporting cannot be ruled out. 10 A recent study in which 130 trained physicians independently assigned causes to 122429 deaths, which occurred in 1$1 million homes in 6671 small areas that were randomly selected to be representative of all of India, based on a structured nonmedical surveyor's field report has put the liver cancer as the 4th commonest cause of death in male and 8th commonest cause of death i...

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Population-based risk factors and resource utilization for HCC: US perspective

Cited by 271 publications

References 12 publications

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

NAFLD—which patients should have hepatocellular carcinoma surveillance?

Role of Surveillance in Prevention of Hepatocellular Carcinoma

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