Population-based reference values for bone mineral density in young men

Høiberg, Mikkel; Nielsen, Troels Halfeld; Wraae, Kristian; Abrahamsen, Bo; Hagen, Claus; Andersen, Marianne; Brixen, Kim

doi:10.1007/s00198-007-0399-8

Cited by 47 publications

(30 citation statements)

References 49 publications

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“…Except for the 17 years old boys and girls in the ALSPAC cohort, reporting higher BMD levels at the hip [27] , most studies report lower BMD values for total hip and total body than Fit Futures do [28][29][30][31][32]. After converting Hologic measurements to GE-Lunar [33] mostly all our mean BMD values remained higher, which support our conclusions; the overall tendency of higher Fit Futures than Lunar values, may be explained by true population differences.…”

Section: Discussionsupporting

confidence: 80%

The Tromsø Study: Fit Futures: a study of Norwegian adolescents’ lifestyle and bone health

et al. 2014

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Summary Bone mass achievement predicts later fracture risk. This population-based study describes bone mineral density levels (BMD) and associated factors in Norwegian adolescents. Compared with international reference ranges, BMD levels appear higher and physical activity levels are positively associated with BMD.Purpose Norway has one of the highest reported incidences of osteoporotic fractures. Maximization of peak bone mass may prevent later fractures. This population-based study compared BMD levels of Norwegian adolescents with international reference ranges and explored associated factors.Methods All first year upper secondary school students, aged 15-19 years in the Tromsø region were invited to the Fit Futures study in 2010-2011. Over 90% of the invited participants attended, 508 girls and 530 boys. BMD was measured at total hip, femoral neck and total body by dual x-ray absorptiometry.Lifestyle variables were collected by self-administered questionnaires and interviews. All analyses were performed sex stratified, using linear regression models.Results In girls mean BMD (SD) was 1.060 (0.124), 1.066 (0.123) and 1.142 (0.077) g/cm² at the total hip, femoral neck and total body respectively. In boys corresponding values were 1.116 (0.147), 1.103 (0.150) and 1.182 (0.097), with significant higher values than the Lunar pediatric reference at 16 years of age In girls, height and self-reported intensive physical activity of more than four hours a week and early sexual maturation were positively associated with BMD at both femoral sites (p<0.047). Among boys age, height, body mass index, physical activity and alcohol intake were positively (p<0.038), whereas early stages of sexual maturation and smoking was negatively (p<0.047) related to BMD.Conclusions Despite the heavy fracture burden, Norwegian adolescents´ BMD levels are higher than agematched Caucasians. Physical activity is associated with 1 SD increased BMD levels in those involved in competition or hard training.

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Section: Discussionsupporting

confidence: 80%

The Tromsø Study: Fit Futures: a study of Norwegian adolescents’ lifestyle and bone health

et al. 2014

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“…The bone density throughout the intact femur was predicated to be in range of 0.33 and 1.63 gr/cm'' which agrees with the clinical observations [61,62]. Furthermore, the density distribution in the intact femur is consistent with the CT results obtained by Truong et al [59].…”

Section: Discussionsupporting

confidence: 89%

“…The cube was fixed from the rear plane and loaded on the front plane (shown in the figure). Applying high level stress (±80MPa) induced the average bone density of 1.51 gr/cm"', which is in a good agreement with the clinical results [62]. However, the reduction of mechanical stress to ±10MPa caused the average bone density of the cube to decrease by 41%.…”

Section: Conflict Of Interestsupporting

confidence: 64%

Predicting Bone Remodeling in Response to Total Hip Arthroplasty: Computational Study Using Mechanobiochemical Model

Avval

Klika

Bougherara

2014

Journal of Biomechanical Engineering

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Periprosthetic bone loss following total hip arthroplasty (THA) is a serious concern leading to the premature failure of prosthetic implant. Therefore, investigating bone remodeling in response to hip arthroplasty is of paramount for the purpose of designing long lasting prostheses. In this study, a thermodynamic-based theory, which considers the coupling between the mechanical loading and biochemical affinity as stimulus for bone formation and resorption, was used to simulate the femoral density change in response to THA. The results of the numerical simulations using 3D finite element analysis revealed that in Gruen zone 7, after remarkable postoperative bone loss, the bone density started recovering and got stabilized after 9% increase. The most significant periprosthetic bone loss was found in Gruen zone 7 (-17.93%) followed by zone 1 (-13.77%). Conversely, in zone 4, bone densification was observed (+4.63%). The results have also shown that the bone density loss in the posterior region of the proximal metaphysis was greater than that in the anterior side. This study provided a quantitative figure for monitoring the distribution variation of density throughout the femoral bone. The predicted bone density distribution before and after THA agree well with the bone morphology and previous results from the literature.

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“…In that study mineralization of primary lamellar bone as assessed by X-ray diffraction (ratio of Amide I/phosphate) was found to increase significantly between 17 and 36 years of age (n = 3 cadavers). This coincides with the timing of peak bone mass which occurs between the second to third decade life for males (van der Sluis et al, 2002;Hoiberg et al, 2007). Thereafter, the mineralization of primary lamellar bone plateaued for individuals between 44 and 73 years of age (n = 3 cadavers).…”

Section: Discussionmentioning

confidence: 88%

In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy

et al. 2008

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Population-based reference values for bone mineral density in young men

Abstract: Locally derived reference values are important to avoid false positive or false negative findings during work-up in patients evaluated for osteoporosis.

Cited by 47 publications

References 49 publications

The Tromsø Study: Fit Futures: a study of Norwegian adolescents’ lifestyle and bone health

The Tromsø Study: Fit Futures: a study of Norwegian adolescents’ lifestyle and bone health

Predicting Bone Remodeling in Response to Total Hip Arthroplasty: Computational Study Using Mechanobiochemical Model

In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy

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