Population-Based Prevalence, Incidence, and Disease Burden of Autoimmune Hepatitis in South Korea

Kim, Bo H.; Choi, Hoon; Ki, Moran; Kim, K.-A.; Jang, Eun Sun; Jeong, Sook Hyang

doi:10.1016/s0168-8278(16)00705-4

Cited by 12 publications

(29 citation statements)

References 18 publications

(38 reference statements)

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“…A population‐based study from South Korea, which was undertaken with a more reliable study design, reported that the prevalence of PBC was 4.75 per 100 000 population, almost one‐seventh of that in Japan. Interestingly, the above‐mentioned study also indicated that the prevalence of AIH was 4.8, which is significantly lower than that in Japan (Table ). Although the reasons for this difference are unclear, environmental factors in South Korea could conceivably play a protective role with reference to the development AIH and PBC.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, the point prevalence of AIH per 100 000 population increased from 10.7 in 2003 to 17.3 in 2009 in Sweden, even though the methodology was different in these two studies . In South Korea, while the incidence of AIH was stable, the prevalence increased gradually from 2009 to 2013 . Rising prevalence of PBC over time has consistently been reported from the Netherlands, northern Italy and Denmark, Hong Kong, Canada, and the USA, and it is a point of debate whether the incidence of PBC is also increasing.…”

Section: Discussionmentioning

confidence: 99%

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Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Tanaka

Mori

Matsumoto

et al. 2019

Hepatology Research

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Aim Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) impose a significant burden on public health, and it is important to estimate their prevalence. We carried out a nationwide, hospital‐based, epidemiological survey of AIH, PBC, and PSC, and compared the results with those from previous surveys. Method We randomly selected health‐care facilities used in the survey from a list of all facilities in Japan. The selection rate was determined according to a stratification based on the facility characteristics and scale. We sent questionnaires to the selected facilities enquiring about the number and sex of patients with AILD who visited the facility in 2016. An identical survey was undertaken for AIH/PBC in 2004 and for PSC in 2007; we carried out a comparative analysis of these data. Results We selected 1793 departments from health centers all over Japan. Of them, 1078 (60.1%) responded to the questionnaires. The number of reported patients with AIH, PBC, and PSC was 8505, 10 847, and 906, respectively, and point prevalence was 23.9 (95% confidence interval, 23.3–24.5) for AIH (8.7 in 2004), 33.8 (33.0–34.6) for PBC (11.6 in 2004), and 1.80 (1.75–1.85) for PSC (0.95 in 2007) per 100 000 population. Male‐to‐female patient ratio of AILD was 1:4.3 for AIH (1:6.9 in 2004), 1:3.9 for PBC (1:7.1 in 2004), and 1:0.88 for PSC (1:1.4 in 2007). Conclusion The current study indicates an increasing trend of prevalence as well as male‐to‐female patient ratio of AILD in Japan.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Tanaka

Mori

Matsumoto

et al. 2019

Hepatology Research

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“…The database contains billing data provided by physicians and pharmacists, including data regarding services performed, admissions, diagnoses, procedures, discharge statuses, and patient demographics. It has been used for nationwide, population‐based studies of various diseases and for investigations into rare disease trends or statuses, including IBD . Despite its strengths, the nature of the data hinders the accuracy of the operational definitions for disease diagnoses in real practice.…”

Section: Introductionmentioning

confidence: 99%

Emerging trends of inflammatory bowel disease in South Korea: A nationwide population‐based study

Kwak

Myung

Lee

et al. 2018

J of Gastro and Hepatol

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Background and Aim Little is known regarding the exact burden of inflammatory bowel disease (IBD) in Asian countries because previous epidemiologic studies were hospital based. We aimed to develop and validate an operational definition of IBD cases from health insurance claims data and to examine the epidemiological features of IBD in Korea. Methods We analyzed stratified sample data from the Korean Health Insurance Review and Assessment (2010–2016) database using 12 different definitions and applied the best definition to the entire (2007–2016) dataset. Results The definition that combined the International Classification of Disease 10th revision code with IBD‐specific medications had the best performance characteristics among the 12 tested definitions. During the 8‐year study period, IBD prevalence increased from 25 345 in 2009 to 47 444 in 2016. Over that period, the prevalence of Crohn's disease increased 1.9‐fold (from 16.0/100 000 in 2009 to 29.6/100 000 in 2016) and that of ulcerative colitis increased 1.6‐fold (from 41.4/100 000 in 2009 to 66.0/100 000 in 2016). Similarly, the estimated incidence of Crohn's disease also increased 1.2‐fold (from 2.4 to 2.9 per 100 000) and that of ulcerative colitis rose 1.3‐fold (from 4.0 to 5.3 per 100 000). During the study period, the predominant increase in IBD incidence was among younger individuals, especially those aged < 30 years. Conclusion Patients with IBD can be accurately identified using Korean insurance claims data by combining information regarding the International Classification of Disease 10th revision codes and the IBD medications used. The prevalence of IBD continues to increase, with an apparent shift toward younger (< 30 years) age groups.

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“…A total of 17 studies reporting the incidence of AIH and the study characteristics are shown in Table 1, with 11 from Europe, 6,7,9,11,12,[19][20][21][22][23][24] three from Asia, 5,8,25 and three from America. [26][27][28] Sixteen studies reporting AIH prevalence rates were included, with nine from Europe, 6,7,9,11,12,20,21,23,24 two from America, 4,29 and five from Asia.…”

Section: Resultsmentioning

confidence: 99%

“…4 Until now, a number of population-based epidemiological studies of AIH have been reported with great variations. [4][5][6][7][8][9] This may be partly due to the wide spectrum of clinical presentation and lack of specific biomarkers and simple diagnostic criteria. Recently, several researches demonstrated that the incidence and prevalence of AIH were increasing, [9][10][11][12] not only in Europe and Northern America 9,11,12 but also in some Asian countries.…”

Section: Introductionmentioning

confidence: 99%

Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

Zeng

et al. 2019

J of Gastro and Hepatol

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Background and Aim Reported incidence and prevalence rates of autoimmune hepatitis (AIH) have been sparse and heterogeneous. The aim of this meta‐analysis was to estimate the worldwide incidence and prevalence rates of AIH and reveal population difference. Methods Published articles on the epidemiology of AIH in PubMed, Embase, and Cochrane Library were systematically searched from inception to April 28, 2019. Two investigators independently reviewed these literatures and evaluated their quality. A random‐effects model was used to pool the overall incidence and prevalence rates. The impact of population difference, gender, age, study period, study quality, diagnostic criteria, and study design was further analyzed with subgroup analysis and meta‐regression. Results A total of 22 studies were included in the meta‐analysis. The pooled worldwide annual incidence and prevalence of AIH were 1.37 (95% confidence interval [CI]: 0.95–1.80) and 17.44 (95% CI: 12.01–22.87) per 100 000 persons, respectively. Subgroup analysis showed that the pooled annual incidence for Asian, European, and American population was 1.31 (95% CI: 0.42–2.20), 1.37 (95% CI: 1.10–1.64), and 1.00 (95% CI: 0.44–1.56) per 100 000 persons, respectively; the pooled prevalence for Asian, European, and American population was 12.99 (95% CI: 2.05–23.92), 19.44 (95% CI: 15.63–23.24), and 22.80 (95% CI: −13.48 to 59.07) per 100 000 persons, respectively. In addition, higher incidence and prevalence rates were observed in women than men, and a higher prevalence rate was observed in elderly than young people. Conclusions Autoimmune hepatitis is a rare disease, with a similar incidence worldwide and a higher prevalence in European and American than in Asian population.

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Population-Based Prevalence, Incidence, and Disease Burden of Autoimmune Hepatitis in South Korea

Abstract: Background and aim

Cited by 12 publications

References 18 publications

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Emerging trends of inflammatory bowel disease in South Korea: A nationwide population‐based study

Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

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