Emerging trends of inflammatory bowel disease in South Korea: A nationwide population‐based study

Abstract

Background and Aim Little is known regarding the exact burden of inflammatory bowel disease (IBD) in Asian countries because previous epidemiologic studies were hospital based. We aimed to develop and validate an operational definition of IBD cases from health insurance claims data and to examine the epidemiological features of IBD in Korea. Methods We analyzed stratified sample data from the Korean Health Insurance Review and Assessment (2010–2016) database using 12 different definitions and applied the best definition to the entire (2007–2016) dataset. Results The definition that combined the International Classification of Disease 10th revision code with IBD‐specific medications had the best performance characteristics among the 12 tested definitions. During the 8‐year study period, IBD prevalence increased from 25 345 in 2009 to 47 444 in 2016. Over that period, the prevalence of Crohn's disease increased 1.9‐fold (from 16.0/100 000 in 2009 to 29.6/100 000 in 2016) and that of ulcerative colitis increased 1.6‐fold (from 41.4/100 000 in 2009 to 66.0/100 000 in 2016). Similarly, the estimated incidence of Crohn's disease also increased 1.2‐fold (from 2.4 to 2.9 per 100 000) and that of ulcerative colitis rose 1.3‐fold (from 4.0 to 5.3 per 100 000). During the study period, the predominant increase in IBD incidence was among younger individuals, especially those aged < 30 years. Conclusion Patients with IBD can be accurately identified using Korean insurance claims data by combining information regarding the International Classification of Disease 10th revision codes and the IBD medications used. The prevalence of IBD continues to increase, with an apparent shift toward younger (< 30 years) age groups.

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

“…The clinical features such as diarrhea, sputum, pus and bloody stools, abdominal pain, and ulcerative colitis are recurrent chronic diseases and can occur at any age, for both male and female, more common in young and middle-aged, mostly in western developed countries [27]. In recent years, the incidence of UC is on the rise and tends to be younger [28], but its etiology and pathogenesis have not yet been fully clarified. It is currently believed to be mainly related to genetics, infection, environment, and immunity [29].…”

The four epidemiological stages in the global evolution of inflammatory bowel disease

“…For example, in Taiwan, IBD prevalence doubled from 4.54 per 100,000 in 2001-2005 to 9.39 per 100,000 in 2006-2010 but was just short of doubling again in 2011-2015, suggesting a roughly 5-year Prevalence Doubling Period 78 . By contrast, in South Korea, which began westernizing earlier, the prevalence of IBD was 57.37 per 100,000 in 2009, but had not quite doubled to 95.59 per 100,000 in 2016, suggesting a Prevalence Doubling Period closer to 10 years 79 .…”

“… 88 ), 63.8 per 100,000 in 2010 and 92.8 per 100,000 in 2015 (ref. 79 ). If the prevalence of IBD follows a similar trend in regions such as India and China with populations of more than one billion people 57 , 89 , Asia alone might have more cases of IBD than the Western world before 2050 (ref.…”

Perilla Oil Alleviates High-Fat Diet-Induced Inflammation in the Colon of Mice by Suppressing Nuclear Factor-Kappa B Activation

“…2 Furthermore, a recent report revealed that the prevalence of IBD in Korea is growing steadily, and the affected population is shifting toward young adults (19-30 years old). 3 Kim et al previously showed that high-fat diet (HD) alters the gut microbial population resulting in increased endotoxin levels. Endotoxins, such as lipopolysaccharide (LPS), contribute to the onset of inflammation through the induction of Toll-like receptors, which activate nuclear factor-jB (NF-jB) by phosphorylating inhibitor jB (IjB).…”