Population‐Based Age‐ and Sex‐Specific Incidence Rates in the 4 Main Types of Leukaemia

Abstract

Due to recent developments in clinical haematology, 98.8 % of all 1980 cases of leukaemia reported to the Danish Cancer Registry during the 4-year period 1973-76 could be subclassified into the 4 main types of leukaemia. Thus, it has been possible to characterize each of these types more accurately than before regarding age-and sex-specific incidence rates, relative frequency, male/female ratio, and median age at diagnosis. Chronic lymphatic leukaemia constituted 38 '90 and chronic myeloid leukaemia 15 '90 of the cases. These figures are larger and smaller, respectively, than these previously reported. The median age of all cases combined was 67 years, and the median age in cases of acute non-lymphocytic leukaemia was 64 years with 59 % of the latter patients more than 60 years of age. In childhood myeloid leukaemia, an early incidence peak, not previously described, was observed before the age of 2 years. Analysis of Danish leukaemia incidence rates from 1943 and onwards shows no increase over 3 decades in patients less than 75 years of age. Thus, the observed increase in incidence from 5866-9942/100000 during the period studied is limited to the very oldest age groups and is probably due to improved diagnostic efforts.

Hematological malignancies diagnosed by bone marrow examination in a tertiary hospital at Uttarakhand, India

“…Similar fi ndings have been reported by many authors like Roda L et al [20], Pradhan P et al [8], Rani S et al [11], Kasthuri S et al [21], Kushwaha et al [14], and D'costa G et al [19]. A markedly high incidence of CLL has been given by Kwiat Kowski A [6], Hansen NE et al [10] and Brincker H [22] who reported CLL as being more common than CML in Poland, Denmark and Scandinavia respectively. We found maximum cases of ALL upto 4 years of age as has also been reported by Van Steensel Moll NA et al [16], Clavel J et al [23] and Monge P et al [17].…”

A Rare Case of CML with Abnormally High TLC Count

“…CML occurs in 7% to 15% of all leukemias in adults with approximately 1 to 1.5 cases per 100,000 population [4,5]. Asymptomatic cases of CML have increased from 15% to about 40% of all cases.A European study published in 2007 estimates the CML incidence to be 1-2 cases per 100,000 people every year [6].The activity of leukocyte alkaline phosphatase is reduced in nearly all patients at diagnosis [7].According to Medscape total WBC count 20,000-60,000 cells/μL in CML with mildly increased basophils and eosinophils while in our patient it was 175,000/uL.…”

Prognosis of Acute Myeloid Leukemia in the General Population: Data from Southern Switzerland

“…The median age of our population was 67, and more than 60% of the cases were older than 60. The issue of how to treat these subjects remains a concern 7,17,24 . Even though a definitive cure after 60 is a rare event, some patients can achieve a CR, sometimes durable, with potential positive impact on quality of life 25,26 .…”