Hematological malignancies diagnosed by bone marrow examination in a tertiary hospital at Uttarakhand, India

Kusum, Anuradha; Negi, Gita; Gaur, Dushyant Singh; Kishore, Sanjeev; Harsh, Meena; Sharma, Anita; Verma, Shilp

doi:10.1007/s12288-008-0016-9

Cited by 11 publications

(13 citation statements)

References 17 publications

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“…Bleeding was also a common presenting feature. Similar findings have been reported in other studies on AML [11,12]. Rogers et al have documented that pallor and fever were prominent feature in majority of subtypes [14].…”

Section: Resultssupporting

confidence: 90%

“…A lot of preceding studies had stated a greater incidence of AML in males though the male prevalence is not as distinctive as in ALL [5,6] in a study by male preponderance was also present, with a male to female ratio of 1.61:1.0. Greater incidence of all leukemia in males appears to rise as males are relatively more exposed to work-related and environmental hazards as has been submitted by some studies [10][11][12]. As regards age it was observed that at the time of presentation majority of patients (85.9%) was in the group of 25-60 years and only 14.1% of cases were in between 10-25 years of age.…”

Section: Resultsmentioning

confidence: 80%

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Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh

Chang¹,

Shamsi²,

Waryah³

2016

J Hematol Thrombo Dis

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In Acute Myeloid Leukemia (AML) patients, a diversity of clinical and hematological parameters has been examined for possible value in calculating treatment response and survival. The study was conducted at National Institute of Bone Diseases, Karachi (NIBD), Sind, Pakistan, a tertiary care and teaching hospital, affiliated with Liaquat University of Medical and Health Sciences, Jamshoro. This study included 107 cases of de novo AML, both male and female patients of ages between 10-60 years were selected randomly. The clinical features included fever, weakness, loss of weight, vomiting, bleeding gums, liver and spleen enlargement, lymph node enlargement. The Laboratory investigations included CBC (Complete Blood Count) specifically heamoglobin percentage, total leucocyte count, platelet count and blast count: peripheral blood smears, bone marrow aspiration biopsy, trephine biopsy, cytochemistry (Myeloperoxidase Staining, Immunohistochemistry (CD markers)) and DNA extraction for genetic sequencing. Percentage, validity and cumulative index were calculated of all parameters. It was found that about 70% of AML patients were adults and FAB subtype M2 of acute myeloid leukemia was more prevalent than other subtypes, followed by AML, M1.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 80%

Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh

Chang¹,

Shamsi²,

Waryah³

2016

J Hematol Thrombo Dis

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“…Compared with the data from other studies carried out in a single center, the frequency of our HM (20.7 NC/year) is similar to that found by Koulidiati, in Burkina Faso and Thiam, in Senegal which were respectively 22.13 and 22.14 NC/year. 5,16 This result is also consistent with the overall incidence of HM found in African studies, which was 5.28 NC/year for Mahboub et al, 16 4,5,7,[16][17][18][19][20][21] The frequency of our HM is nevertheless lower than that found in the Asian monocentric studies for which the frequency of HM which was 27.1 NC/year for Kusum et al, 30 NC/year for Idris et al, 69.7 NC/year for Al-ghazali et al, and 75 NC/year for Al-Kahiri et al 6,13,22,23 The frequency of our HM is far lower than that found in multicenter studies such as those of Errahhali et al, in Morocco and Hossain et al, in Bangladesh for which it was respectively 132 and 1002.6 NC/year. 12,24 The frequency of our HM is also far lower than that found in the cancer registries of countries possessing these tools: HM frequency was 363.2 NC/year for Broccia et al, in Sardinia (Italy), 2,700 NC/year for McNally et al, in United Kingdom and 230,000 NC/year for Rodriguez-Abreu in Europe.…”

Section: Discussioncontrasting

confidence: 66%

Epidemiology and clinical aspects of hematological malignancies at the military hospital of Antananarivo

et al. 2019

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Background: Malignant hemopathies constitute a group of pathologies having in common the anomalies of the bone marrow or of the lymphatic system cells. In developed countries, the number and actual distribution of cancers is provided by cancer registries. In Madagascar there is no effective cancer registry and only two studies on malignant hemopathies have been carried out to date, but neither has described their epidemiology and clinical aspects. Thus, we aimed to describe the epidemiology and clinical aspects of malignant hemopathies managed in the Medical Oncology Unit of the Military Hospital of Antananarivo.Methods: It was a cross-sectional and descriptive study carried out at this unit from 1st December 2012 to 31st August 2015 (33 months). Authors included all patients followed, then excluded those without pathologic evidence, cases of monoclonal gammapathy of unknown significance and cases of solid cancers.Results: We followed up 57 cases of malignant hemopathies. The mean age was 49.39±15.46 years and the sex ratio was 1.71. Superficial lymphadenopathy was the most frequent warning signs (31.58%) and lymphomas were most represented (52.63%). There was a significant association between warning signs and diagnosis (p value <0.001).Conclusions: Present results are grossly similar to those of other African authors. Present results are distinguished by a low proportion of chronic myeloid leukemia and a very low proportion of chronic lymphocytic leukemia compared to literature data. The effectiveness of the cancer registry will allow us to improve the knowledge about frequency and current distribution of cancer in Madagascar.

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“…Lymphoid neoplasm included MBCN 43.6%, ALL 7.3%, HL 5.5% and MTCN 3.6%. In this study, Plasma cell Neoplasm (PCN) (29%) was the commonest lymphoid neoplasm followed respectively by Non Hodgkin Lymphoma (NHL) 14 We had two Patients less than 20 years of age, T ALL and LCH was seen accounting each o.9% of HM. In young adult Patient of 21 to 40 years of age, NHL was the most common HM with 9.09% followed by AML 4.5%, MPN (CML) 4.5%, B ALL 2.7%, T ALL 0.9%, HL 0.9% and LCH 0.9%.…”

Section: Resultsmentioning

confidence: 99%

“…CLL, AML, ALL, and finally MDS. 7 PCN (Multiple myeloma) has been seen to affect males for frequently 14. In female also, Lymphoid Neoplasm was most frequent HM with 14.5% followed by Myeloid Neoplasm of 11.8%.…”

mentioning

confidence: 99%

Spectrum of Haematological malignancies managed at tertiary centre: A one-year retrospective review

Shrestha

Thapa

Mnandhar

et al. 2018

J. Soc. Surg. Nepal

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Introduction: Hematological malignancies are not uncommon and all ages and genders are affected. Hematological malignancies are a group of cancers that arise from a malignant transformation of cells of the bone marrow or lymphatic system. There are several classification systems for Hematological Malignancies. The WHO classification was the first worldwide consensus classification on hematological tumors. Methods:We retrospectively collected data from the Department of Pathology and Hematology Unit of Internal medicine from 2015 to 2016. Hematological malignancies were analyzed clinically and with laboratory parameters. They were initially analyzed with complete blood counts and peripheral smear and diagnosed on the basis of Bone marrow morphological assessment, Immunophenotyping and cytogenetic and molecular markers and histopathology and Immunohistochemistry of Excised lymph node when applicable. Plasma cell dyscrasias were assessed clinically for features of CRAB (hypercalcemia, renal impairment, anemia and lytic lesion) and evaluation was done by hemogram, biochemical parameters and skeletal survey. Later plasma cell dyscrasias was diagnosed on the basis of bone marrow study, Immunofixation electrophoresis, serum free light chain assay, serum protein electrophoresis and myeloma defining events.Results: There were 110 cases of hematological neoplasm from Feb 2015 till Jan 2016. Lymphoid neoplasm was the commonest hematological malignancies with 60.9% followed by myeloid neoplasm of 37.3% then histiocytic neoplasm of 1.5%. Median age at diagnosis for all Hematological malignancies was 55 years of age. In patients under 20 years of age, T ALL and LCH accounted each with o.9%. In young adult Patient, NHL was the most common HM whereas; MPN was the most common HM in adults. In older patients, PCN was the most common HM.Male were more prevalent than female in Hematological malignancies. Male accounted for 73.6% and female were 26.4% with male female ratio 2.7:1. In both male and female , Lymphoid Neoplasm was most frequent HM. In male PCN was the most frequent HM. In female, NHL, PCN and MPN was the most frequent HM.Lymphoid neoplasm included Mature B cell Neoplasm (MBCN) 43.6%, Acute Lymphoblastic Leukemia (ALL) 7.3%, Hodgkins Lymphoma (HL) 5.5% and Mature T cell Neoplasm (MTCN) 3.6%. Plasma cell Neoplasm (PCN) (29%) was the commonest lymphoid neoplasm. Among the myeloid neoplasm (MN), Myeloproliferative neoplasm (MPN) accounted 19.1% followed by acute myeloid leukemia (AML) with 14.5% then Myelodysplastic syndrome (MDS) 4.5%. Chronic Myeloid Leukemia (CML) is the commonest HM among different subtypes of MPN.Conclusion: HM can occur at any age group with median age at diagnosis of 55 years. Overall men are more affected with HM than women. In both male and female Lymphoid malignancies are frequent HM. There is difference in distribution pattern and subtypes of Hematological malignancies at different age group.

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Hematological malignancies diagnosed by bone marrow examination in a tertiary hospital at Uttarakhand, India

Cited by 11 publications

References 17 publications

Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh

Clinical and Hematological Profile of Acute Myeloid Leukemia (AML) Patients of Sindh

Epidemiology and clinical aspects of hematological malignancies at the military hospital of Antananarivo

Spectrum of Haematological malignancies managed at tertiary centre: A one-year retrospective review

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