Population Balance Modeling of the Solution‐Mediated Transformation of <i>DL</i>‐Methionine Polymorphs

Wantha, Lek; Flood, Adrian E.

doi:10.1002/ceat.201300034

Cited by 15 publications

(20 citation statements)

References 18 publications

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“…In literature, a lot of studies demonstrate that the growth of the stable polymorph is the limiting step, e.g., L ‐glutamic acid 22–25, taltireline 26, and carbamazepine 5, 27. The SMT of DL ‐methionine 6 and glycine 28 are at least two examples where the dissolution of the metastable polymorph was the limiting step.…”

Section: Resultsmentioning

confidence: 99%

“…Polymorphic crystallizations consist of the competitive nucleation and crystal growth of the polymorphs and the transformation from the metastable polymorph to the stable polymorph, usually via a solution‐mediated transformation (SMT) mechanism. This involves nucleation and crystal growth of the stable polymorph and dissolution of the metastable polymorph 3–6. Therefore, the mechanism and kinetics of each elementary step in the crystallization process needs to be understood to predict and control the formation of the appropriate polymorph.…”

Section: Introductionmentioning

confidence: 99%

“…Accurate modeling of the SMT can be performed by creating separate models of each of the mechanisms involved and combining these models within the framework of the population balance equation (PBE) 6–8, which is a two‐step method. Firstly, the rates of the crystallization processes, i.e., nucleation and growth, and the rate of dissolution of each polymorph are obtained through specific experiments.…”

Section: Introductionmentioning

confidence: 99%

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Growth and Dissolution Kinetics of A and B Polymorphs of L‐Histidine

Wantha

Flood

2015

Chem Eng & Technol

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The growth rate of the stable polymorph A and the dissolution rate of the unstable polymorph B of L-histidine (L-his) in aqueous solution were experimentally determined at varying temperatures. The growth and dissolution kinetics were measured by means of desupersaturation and deundersaturation techniques, respectively. Both the growth and dissolution rates increase with higher temperature. At all temperatures studied, the dissolution rate of form B is faster than the growth rate of form A, indicating that the solution-mediated transformation of the polymorphs of L-his is likely to be controlled by the growth rate of form A. Both kinetics of the polymorphs of L-his will be used to characterize the polymorphic transformations and the overall crystallization rate of L-his.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Growth and Dissolution Kinetics of A and B Polymorphs of L‐Histidine

Wantha

Flood

2015

Chem Eng & Technol

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“…In general, a metastable polymorph crystallizes first and tends to transform into a more stable one 6. The transformation process usually occurs through interactions with a solution phase and is called solution‐mediated polymorphic transformation (SMPT) 7, 8.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal (Mn, Fe, Co, Ni)‐Doped Graphene Hybrids for Electrocatalysis

Toh

Poh

Sofer

et al. 2013

Chemistry An Asian Journal

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The development of electrocatalysts is crucial for renewable energy applications. Metal-doped graphene hybrid materials have been explored for this purpose, however, with much focus on noble metals, which are limited by their low availability and high costs. Transition metals may serve as promising alternatives. Here, transition metal-doped graphene hybrids were synthesized by a simple and scalable method. Metal-doped graphite oxide precursors were thermally exfoliated in either hydrogen or nitrogen atmosphere; by changing exfoliation atmospheres from inert to reductive, we produced materials with different degrees of oxidation. Effects of the presence of metal nanoparticles and exfoliation atmosphere on the morphology and electrocatalytic activity of the hybrid materials were investigated using electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and cyclic voltammetry. Doping of graphene with transition metal nanoparticles of the 4th period significantly influenced the electrocatalysis of compounds important in energy production and storage applications, with hybrid materials exfoliated in nitrogen atmosphere displaying superior performance over those exfoliated in hydrogen atmosphere. Moreover, nickel-doped graphene hybrids displayed outstanding electrocatalytic activities towards reduction of O2 when compared to bare graphenes. These findings may be exploited in the research field of renewable energy.

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“…The functions used to express the nucleation rates for both the stable and metastable forms of L-glutamic acid were different in the mentioned studies: Cornel at al. (2009) and Sheikoleslamzadeh and Rohani The solution-mediated transformation of DL-methionine polymorphs was modelled by Wantha and Flood (2013) (Trifkovic et al 2012). Such model was solved using the methods of moments.…”

Section: Control Approach Referencementioning

confidence: 99%