Poor Oral Health, That Is, Decreased Frequency of Tooth Brushing, Is Associated With Endothelial Dysfunction

Kajikawa, Masato; Nakashima, Ayumu; Maruhashi, Tatsuya; Iwamoto, Yumiko; Iwamoto, Akimichi; Matsumoto, Takeshi; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Taguchi, Akira; Noma, Kazuhiro; Higashi, Yukihito

doi:10.1253/circj.cj-13-1330

Cited by 28 publications

(26 citation statements)

References 37 publications

(16 reference statements)

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“…The degree of endothelial dysfunction of the brachial artery was evaluated using a FMD test, as described elsewhere [10]. Briefly, the use of alcohol, caffeine, or vasoactive drugs and smoking were restricted during the fasting period.…”

Section: Measurement Of Fmdmentioning

confidence: 99%

The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea

Oyama

Nagashima

Yoshioka

et al. 2016

Journal of Cardiology

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Section: Measurement Of Fmdmentioning

confidence: 99%

The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea

Oyama

Nagashima

Yoshioka

et al. 2016

Journal of Cardiology

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“…We focused on the lifestyle about the frequency of toothbrushing practices because toothbrushing is one of the most familiar and easiest methods to improve oral hygiene in the general population. A recent study showed that low frequency of toothbrushing was associated with endothelial dysfunction [9], but why low frequency of toothbrushing was associated with arteriosclerosis remains unclear. Epidemiologic evidence about the association, however, should be accumulated.…”

Section: Introductionmentioning

confidence: 99%

Low frequency of toothbrushing practices is an independent risk factor for diabetes mellitus in male and dyslipidemia in female: A large-scale, 5-year cohort study in Japan

Kuwabara

Motoki

Sato

et al. 2017

Journal of Cardiology

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“…Flow-mediated vasodilation (FMD) as an index of endothelium-dependent vasodilation and nitroglycerine-induced vasodilation as an index of endotheliumindependent vasodilation in the brachial artery using high-resolution ultrasound provide useful information on vascular function (10)(11)(12)(13)(14)(15)(16). Endothelial dysfunction occurs in the early stage of atherosclerosis, leading to the maintenance and progression of atherosclerosis, resulting in cardiovascular complications (17).…”

mentioning

confidence: 99%

Ratio of Serum Levels of AGEs to Soluble Form of RAGE Is a Predictor of Endothelial Function

et al. 2014

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OBJECTIVEAdvanced glycation end products (AGEs) and their specific receptor, the receptor for AGEs (RAGE), play an important role in atherosclerosis. Recently, a soluble form of RAGE (sRAGE) has been identified in human serum. However, the role of sRAGE in cardiovascular disease is still controversial. There is no information on the association between simultaneous measurements of AGEs and sRAGE and vascular function. In this study, we evaluated the associations between serum levels of AGEs and sRAGE, ratio of AGEs to sRAGE, and vascular function. RESEARCH DESIGN AND METHODSWe measured serum levels of AGEs and sRAGE and assessed vascular function by measurement of flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation in 110 subjects who underwent health examinations. Multivariate regression analyses were performed to identify factors associated with vascular function. RESULTSUnivariate regression analysis revealed that FMD correlated with age, BMI, systolic blood pressure, diastolic blood pressure, heart rate, triglycerides, HDL cholesterol, glucose, smoking pack-years, nitroglycerine-induced vasodilation, serum levels of AGEs and sRAGE, and ratio of AGEs to sRAGE. Multivariate analysis revealed that the ratio of AGEs to sRAGE remained an independent predictor of FMD, while serum level of AGEs alone or sRAGE alone was not associated with FMD. CONCLUSIONSThese findings suggest that sRAGE may have a counterregulatory mechanism that is activated to counteract the vasotoxic effect of the AGE-RAGE axis. The ratio of AGEs to sRAGE may be a new chemical biomarker of endothelial function.

show abstract

Poor Oral Health, That Is, Decreased Frequency of Tooth Brushing, Is Associated With Endothelial Dysfunction

Cited by 28 publications

References 37 publications

The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea

The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea

Low frequency of toothbrushing practices is an independent risk factor for diabetes mellitus in male and dyslipidemia in female: A large-scale, 5-year cohort study in Japan

Ratio of Serum Levels of AGEs to Soluble Form of RAGE Is a Predictor of Endothelial Function

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