The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea

Oyama, Jun‐ichi; Nagashima, Daisuke; Yoshioka, Goro; Yamasaki, Ayumu; Sato, Michio; Komoda, Hiroshi; Nishikido, Toshiyuki; Shiraki, Aya; Node, Koichi

doi:10.1016/j.jjcc.2015.06.005

Cited by 41 publications

(22 citation statements)

References 46 publications

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“…In another study, male sex and age were also independent risk factors for severe SA in the elderly group 27. Moreover, a strong correlation has been reported between SA severity and biomarkers of systemic inflammation and oxidative stress 28,29. Therefore, it is reasonable to conclude that men and elderly patients have an increased risk of PD, assuming inflammation and oxidative stress play key roles in PD pathophysiology.…”

Section: Discussionmentioning

confidence: 95%

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Chou¹,

Lai²,

Chou³

et al. 2017

NDT

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PurposeSleep apnea (SA)-induced chronic intermittent hypoxia increases oxidative stress and inflammation, which may contribute to the pathophysiology of Parkinson’s disease (PD). This study evaluated the risk of PD following SA diagnosis.Patients and methodsThis was a 3-year nationwide population-based matched cohort study using claims data from the National Health Insurance Research Database (NHIRD), Taiwan. We analyzed 1,944 patients diagnosed as having SA between 1997 and 2005 and a matched cohort of 9,720 non-SA patients from the NHIRD. Patients with a history of PD were excluded. Each patient was followed up for 3 years to evaluate subsequent PD development.ResultsOf the 11,664 patients, 17 (0.9%) and 38 (0.4%) from the SA and matched non-SA cohorts, respectively, were subsequently diagnosed as having PD during follow-up. After adjustments for potential confounders, the SA cohort had a 1.85-fold higher risk of PD than the non-SA cohort (95% confidence interval [CI] =1.02–3.35; P=0.042). After age and sex stratification, PD development was independently associated with SA only in men (adjusted hazard ratio [HR], 2.26; 95% CI =1.11–4.63; P<0.05) and in patients aged ≥60 years (adjusted HR, 1.93; 95% CI =1.01–3.71; P<0.05).ConclusionOur study suggests that patients with SA are at an increased longitudinal risk of PD. Furthermore, age and male sex are independently associated with the risk of PD.

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Section: Discussionmentioning

confidence: 95%

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Chou¹,

Lai²,

Chou³

et al. 2017

NDT

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“…Pathomechanisms between CVD and chronic kidney disease (CKD) are complicated, multifactorial, and yet not completely understood. Various processes, such as vascular calcification [ 1 ], endothelial dysfunction [ 27 ], and chronic inflammation, among others, significantly contribute to development of these diseases [ 28 ]. There is a variety of inflammatory markers, such as CRP [ 29 ]; however, they are expensive and imprecise.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-Lymphocyte Ratio (NLR) Reflects Myocardial Inhomogeneities in Hemodialyzed Patients

Bołtuć

Bociek

Dziugieł

et al. 2020

Mediators of Inflammation

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Introduction. Cardiovascular diseases (CVDs) are a leading cause of death in chronically hemodialyzed (HD) patients. In this group, inflammation exerts significant impact on the prevalence of CVD morbidity and mortality. Spatial QRS-T angle is an independent and strong predictor of CV events, including sudden cardiac death (SCD), both in general population and HD patients. Pathogenesis of widened QRS-T angle is complicated and is not well established. Objectives. The study is aimed at evaluating whether inflammation process can contribute to the wide QRS-T angle. Patients and Methods. The retrospective study was performed on 183 HD patients. The control group consisted of 38 patients. Demographic, biochemical, vectorcardiographic, and echocardiographic data were evaluated in all patients. Inflammation process was expressed as neutrophil-lymphocyte ratio (NLR), as well as C-reactive protein (CRP). Results. Both NLR (3.40 vs. 1.95 (p<0.0001)) and spatial QRS-T angle (50.76 vs. 93.56 (p<0.001)) were higher in the examined group, compared to the control group. Similarly, CRP was higher in the examined group than in the control group (8.35 vs. 4.06 (p<0.001), respectively). The QRS-T angle correlated with NLR, CRP, some structural echocardiographic parameters, parathormone (PTH), and calcium (Ca) concentrations. Multiple regression analysis showed that NLR is an independent QRS-T angle predictor (r=0.498, p=0.0027). The ROC curve analysis indicated the cut-off point of NLR equaled 4.59, where the sensitivity and specificity were the highest for predicting myocardial inhomogeneities expressed as widened QRS-T angle. Conclusion. The NLR, as an inflammation marker, may indicate myocardial inhomogeneities in HD patients.

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“…In studies analyzing factors associated with OSAS severity in recent years, the common and strongest parameter obtained is obesity. [7][8][9][10][11][12][13] Tufik et al [21] reported that obesity was one of the independent risk factors for patients with AHI ≥15, regardless of gender. [21] Based on these data, we grouped our patients as obese (BMI >30 kg/m 2 ) and non-obese (BMI ≤29.9 kg/m 2 ) patients.…”

Section: Discussionmentioning

confidence: 99%

“…[2] The disease is associated with functional disorders such as excessive daytime sleepiness, daytime headaches, disrupted concentration, traffic and work accidents, in addition to somatic disorders including systemic and pulmonary hypertension, ischemic heart disease, and cerebrovascular disease. [3] Many authors have proposed a correlation of the disease or disease severity with a variety of inflammatory mediators, [4][5][6][7] biochemical markers, [8][9][10] and hormonal parameters. [11][12][13] Some studies have emphasized a correlation of the disease with respiratory tract anatomy and loss of genioglossus and pharyngeal muscle function causing pharyngeal collapse in individuals, although it is not possible to explain the problem with a single mechanism.…”

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confidence: 99%

The role of the external nasal measures of patients with sleep disordered breathing in determining disease severity

Avcu¹

2020

tr-ent

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Objectives: In this study, we aimed to investigate the influence of nasal anthropometric measurements on severity of obstructive sleep apnea syndrome (OSAS) and to assess the correlation between nasal anthropometric measurements and severity of OSAS after excluding internal factors causing nasal obstruction. Patients and Methods: A total of 241 consecutive patients (181 males, 60 females; mean age 50.3±11.3 years; range, 18 to 65 years) with daily sleepiness and/or snoring complaints between February 1 st 2018 and December 15 th 2018 were included in the study. All patients were divided into eight groups as obese and non-obese according to the disease severity and BMI values. Results: According to the obese and non-obese groups, none of the anthropometric measurements in the obese group were correlated with OSAS, while only nasal width (r: 0.282, p=0.001), nasal tip height (r: 0.235, p=0.008), and alar-pronasal distance (r: 0.156, p=0.031) were found to be correlated in the non-obese patient groups. Linear regression analysis of variables which appeared to correlate with the OSAS severity revealed that no variables except for age and BMI significantly contributed to the OSAS severity in the obese group. For the non-obese group, in addition to age and BMI values, nasal width significantly contributed to the disease severity. Conclusion: Although there are many factors in the etiology of OSAS, no external nasal anatomic measurement, except for the nasal width, seems to be correlated with the disease severity.

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The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea

Abstract: NLR and endothelial dysfunction significantly correlates with the severity of OSA and FMD and other biochemical parameters improved and NLR decreased significantly after CPAP treatment.

Cited by 41 publications

References 46 publications

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Neutrophil-Lymphocyte Ratio (NLR) Reflects Myocardial Inhomogeneities in Hemodialyzed Patients

The role of the external nasal measures of patients with sleep disordered breathing in determining disease severity

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The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea

Abstract: NLR and endothelial dysfunction significantly correlates with the severity of OSA and FMD and other biochemical parameters improved and NLR decreased significantly after CPAP treatment.

Cited by 41 publications

References 46 publications

Sleep apnea and the subsequent risk of Parkinson&rsquo;s disease: a 3-year nationwide population-based study

Sleep apnea and the subsequent risk of Parkinson&rsquo;s disease: a 3-year nationwide population-based study

Neutrophil-Lymphocyte Ratio (NLR) Reflects Myocardial Inhomogeneities in Hemodialyzed Patients

The role of the external nasal measures of patients with sleep disordered breathing in determining disease severity

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Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study