Pooled analysis of 1270 infective endocarditis cases in Turkey

Abstract

Introduction: Despite developments in medicine, infective endocarditis (IE) is still associated with significant morbidity and mortality. In this study it was aimed to systematically review the infective endocarditis literature published or presented from Turkey.
 Methods: To find the published series, one national database (Ulakbim), and three international databases (Scopus, Pubmed and Sci-e) were searched between 31 October-3 November 2014. also, abstracts of congresses by three national congresses were searched for studies regarding infective endocarditis.
 Results: Data for 1270 patients (38.3% female, mean age 46.2, 28% prosthetic valve endocarditis) with a diagnosis of infective endocarditis were obtained from 21 reports (18 published articles and three congress abstracts). Of the 18 articles, four were in peer-reviewed medical journals indexed in national databases and 14 were in international databases. There was an underlying heart disease in 51.9% and history of dental procedure was 6.7%. Fever, heart murmur and fatigue were present in 94%, 71.4% and 69% respectively. most commonly involved site was mitral valve (43.3%), followed by aortic (33.8%) and tricuspid valve (6.4%). Staphylococcus aureus, coagulase-negative staphylococci and enterococci comprised the 22.8%, 9.7% and 7.5% of the cases while 31.1% were culture-negative. Overall mortality was 23.4%. When we compared series related to years 2008 and before and 2009 and after, the mortality rates were (24.1%-224/931) vs (20.1%-32/159), respectively (p = 0,31).
 Conclusion: Infective endocarditis is still associated with significant mortality. S. aureus seems to be the most common etiologic agent. There was a slight decrease in the recent years in mortality.

Portraying infective endocarditis: results of multinational ID-IRI study

“…Four-fifths, as the significant portion, of patients had left-sided IE affecting aortic and mitral valves with similar rates. Although relatively infrequent [13], we detected multivalvular involvement in one-tenth of our cases. Basically, size matters in endocarditis and bigger vegetations, over 10 mm in particular, boost embolic risks [14].…”

Clinical, Microbiological, and Imaging Characteristics of Infective Endocarditis in Latin America: A Systematic Review

“…In this review, IE mainly affected left-sided valves, which is in line with the findings from other authors worldwide (Habib et al, 2019;Muñoz et al, 2015;Selton-Suty et al, 2012). As expected and consistent with the description of other studies (Habib et al, 2019;Nakatani et al, 2013;Vahabi et al, 2019), vegetations were the most reported and found echocardiographic finding. Other common findings in our review were valvular regurgitation and abscesses.…”

“…On the other hand, RHD information was provided in less than half of the studies (2005 cases). When comparing the presence of RHD in our study to that from other regions, a similar rate of RHD among subjects with IE have been described in Turkey (11%) (Vahabi et al, 2019), but a lower frequency has been reported in higher-income countries like Spain (8%) (Muñoz et al, 2015). This reflects how RHD continues to be a cause of morbidity in developing nations compared to wealthier regions.…”

“…This rate ranged from 14.2% (1970-80s) to 26.1% (1990s) with 23.1% BCNIE cases identified in the last decade. BCNIE is a common finding as reported in studies from different regions, ranging from 14.7% up to 31.1% (Cecchi et al, 2015;Giannitsioti et al, 2021;Habib et al, 2019;Muñoz et al, 2015;Vahabi et al, 2019). Previous antibiotic exposure is a common reason for BCNIE (Lamas and Eykyn, 2003).…”

Destructive Right Valve Endocarditis due to Staphylococcus lugdunensis

“…Ülkemizden, Vahabi ve ark. 1270 endokardit olgusunu kapsayan meta analizlerinde Staphylococcus aureus, koagülaz negatif stafilokoklar ve enterokoklar olguların %22.8'ini, %9.7'sini ve %7.5'ini oluştururken, %31.1 olguda kültür negatif bulunmuş ve total mortalite %23.4 olarak bildirilmiştir (14) . EE tanısında klinik, laboratuvar ve görüntüleme yöntemlerini içeren değiştirilmiş Duke Kriterleri uzun süredir kullanılmaktadır.…”