Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera

Son, Ilhong; Chung, Ill‐Min; Lee, Sung Ik; Yang, Hyun Duk; Moon, Hyung‐In

doi:10.1016/j.bmcl.2007.06.060

Cited by 81 publications

(55 citation statements)

References 15 publications

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“…139,140 Likewise, the isoflavone pomiferin, which is isolated from the fruits of maclura pomifera, possesses HDAC inhibitory activity and inhibits the growth of colon cancer cells in vitro. 141 Therefore, encouraging evidence exists for a potential chemopreventive role for compounds with HDACi activity, although it is noted that these compounds likely exert their effects through multiple mechanisms, including antioxidant activities and reduction of prostaglandin production. 140,142 …”

Section: A Chemopreventive Role For Hdac Inhibitors?mentioning

confidence: 99%

HDACs and HDAC inhibitors in colon cancer

Mariadason¹

2008

Epigenetics

195

190

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Section: A Chemopreventive Role For Hdac Inhibitors?mentioning

confidence: 99%

HDACs and HDAC inhibitors in colon cancer

Mariadason¹

2008

Epigenetics

195

190

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“…The biological activity of osajin is thought to have antioxidant properties that can attenuate the myocardial dysfunction provoked by ischemia reperfusion in rats (72). It has been shown to inhibit the growth of six types of human cancer cell lines in vitro, including renal carcinoma ACHN, lung adenocarcinoma NCI-H23, prostate cancer PC-3, breast cancer MDA-MB-231, melanoma LOX-IMVI, and colon carcinoma HCT-15 cell lines (276). Osajin has demonstrated low toxicity in human hepatocytes compared with human cancer cell lines (276).…”

Section: The Inhibitory Mechanisms Of Natural Compounds Against Npc Smentioning

confidence: 99%

“…It has been shown to inhibit the growth of six types of human cancer cell lines in vitro, including renal carcinoma ACHN, lung adenocarcinoma NCI-H23, prostate cancer PC-3, breast cancer MDA-MB-231, melanoma LOX-IMVI, and colon carcinoma HCT-15 cell lines (276). Osajin has demonstrated low toxicity in human hepatocytes compared with human cancer cell lines (276). However, the mechanism of growth inhibition in human cancer cells by osajin is not clear.…”

Section: The Inhibitory Mechanisms Of Natural Compounds Against Npc Smentioning

confidence: 99%

Potential Therapeutic Molecular Targets for Nasopharyngeal Carcinoma

Chen¹

2012

Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma

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“…Vesela et al [5] showed that the antioxidant profile of highly active pomiferin was comparable to the reference compounds used, while osajin showed only low activities. Pomiferin also has inhibitory effects for anti-cholinesterase [6] and histone deacetylase (HDAC) [7] . Chromatin is a dynamic macromolecular complex that consists of DNA, histones, and non-histone proteins.…”

Section: Introductionmentioning

confidence: 99%

“…Some HDAC inhibitors have been shown to have a potent anti-tumoural effect with a little toxicity in vivo in animal models [8] . The HDAC inhibitors exhibit an anti-proliferative activity on tumour cells [7] . Yang et al [9] suggested that pomiferin has an anti-proliferative effect not only on transformed breast epithelial cells but also on the normal cells.…”

Section: Introductionmentioning

confidence: 99%

Erkek Ratlarda Maclura pomifera Ekstraktının Sisplatin ile Oluşturulmuş Üreme Sistemi Hasarı Üzerine Etkisi

Aksu¹,

Akman²,

Özkaraca³

et al. 2015

Kafkas Univ Vet Fak Derg

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In this study, we aimed to investigate the effect of maclura pomifera (MP) (known as cytotoxic, anti-tumoural, anti-inflammatoric, antinociceptive, and anti-oxidative) extract upon the spermatological parameters in Cisplatin (anti-tumoural chemotherapeutic with Reactive Oxygen Species (ROS)-generating side-effects)-treated rats. A total of seventeen male Sprague Dawley rats, aged eight weeks and weighing 250-300 g, were used. Three experimental groups were assigned, as follows; Group 1 (n=5) as control (C): the animals received intraperitoneal (IP) injection of physiological saline and further saline via oral gavage during 5 days before and after the injection, Group 2 (n=6): single IP injection of 7 mg/kg Cisplatin (CP) and saline via oral gavage as above, and Group 3 (n=6): referred as MP + CP, oral administration of 500 mg/kg/day MP extract during 5 days before and after cisplatin (CP) injection, as above. At the end of the experiment, rats were decapitated and their testes and cauda epididymis weights as well as epididymal sperm parameters were analysed. The CP administration caused a significant (P<0.05) decline in sperm motility and density, with a significant increase in dead spermatozoa. The MP + CP combination also led to a significant decline (P<0.05) in the weights of total cauda epididymis and of testes, but significantly improved (P<0.05) sperm survival as compared to the CP alone. In conclusion; the findings suggested that the MP plus CP combination had an adverse effect upon the total weights of testes and cauda epididymis, however the dead sperm rate was markedly lower than the CP alone. Keywords: Cisplatin, Maclura pomifera extract, Male rat, Sperm, Reproductive system Erkek Ratlarda Maclura pomifera Ekstraktının Sisplatin ile Oluşturulmuş Üreme Sistemi Hasarı Üzerine Etkisi ÖzetBu çalışmanın amacı, maclura pomifera (MP) (sitotoksik, anti-tümöral, yangı önleyici, analjezik/ağrı giderici, ve antioksidan olarak bilinen) ekstraktının sisplatin (ROS (Reaktif oksijen türevleri) -oluşturucu yan etkili anti-tümöral ajan) uygulanan erkek ratların spermatolojik parametreleri üzerine etkisini incelemekti. Araştırmada 8 haftalık yaşta, 250-300 g canlı ağırlığa sahip 17 adet erkek Sprague Dawley ırkı rat kullanıldı. Üç deney grubu oluşturuldu; Grup 1 (n=5): kontrol grubu, hayvanlara intraperitonal (IP) serum fizyolojik enjeksiyonuyla birlikte, enjeksiyondan 5 gün öncesi ve sonrası boyunca oral gavaj yoluyla yine serum fizyolojik verildi. Grup 2 (n=6): Sisplatin (CP) grubu, hayvanlara bir kez IP 7 mg/kg CP enjeksiyonundan 5 gün öncesi ve sonrası boyunca oral yolla serum fizyolojik verildi. Grup 3 (n=6): MP + CP grubu, hayvanlara bir kez İP 7 mg/kg CP enjeksiyonuyla birlikte, enjeksiyondan 5 gün öncesi ve sonrası boyunca oral yolla günlük 500 mg/kg MP ekstraktı verildi. Deney sonunda ratlar dekapite edilerek testis ve kauda epididimis ağırlıkları ile epididimal sperm parametreleri incelendi. CP enjeksiyonu, sperm motilitesi ve yoğunluğunu önemli derecede (P<0.05) düşürdü ve ölü spermatozoa sayısını ar...

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Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera

Cited by 81 publications

References 15 publications

HDACs and HDAC inhibitors in colon cancer

HDACs and HDAC inhibitors in colon cancer

Potential Therapeutic Molecular Targets for Nasopharyngeal Carcinoma

Erkek Ratlarda Maclura pomifera Ekstraktının Sisplatin ile Oluşturulmuş Üreme Sistemi Hasarı Üzerine Etkisi

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