Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

“…), adhesion molecules and NO synthase, leading to further inflammation, necrosis, apoptosis and fibrosis of hepatocytes (11). In addition, the metabolism of alcohol in the liver results in a large number of free radicals, which inhibits fatty acid oxidation, accumulates intrahepatic fat when beyond the body's clearing ability, and also leads to lipid peroxidation of liver cell membrane, resulting in liver cell damage (12). At the same time, these reactive oxygen species will increase the level of endotoxin, and lead to the release of inflammatory mediators, which can also make NF-κB activated, thus generating a large number of inflammatory mediators, to have an inflammatory cascade amplification effect, aggravating liver damage (7).…”

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

“…The favorable impact of polyphenolic compounds on the liver (Figure ) is already applicable in the prevention and treatment of various liver conditions in humans (Boncheva et al, ; Chang et al, ; Ni et al, ; Pezeshki et al, ; Soleimani et al, ). It is very important that polyphenol‐rich food products may be also effective in this organ protection under the conditions of co‐exposure to Cd and various noxious substances, including other heavy metals such as lead (Pb) and arsenic (As), occurring in the natural environment, as well as in many occupational settings (Choudhury et al, ; Kopeć et al, ; Winiarska‐Mieczan, ).…”

“…It is very important to notice that polyphenols are effective in offering protection from Cd toxicity to other organs and tissues, including the kidneys and skeleton, indicating the beneficial influence of these compounds on the whole organism (Aly et al, ; Baiomy & Mansour, ; Brzóska et al, ; Brzóska, Gałażyn‐Sidorczuk, et al, ; Brzóska, Rogalska, et al, ; Brzóska, Rogalska, et al, ; Farag et al, ; Izaguirry et al, ; Kopeć et al, ; Wani et al, ). Moreover, polyphenolic compounds are known to protect the liver from the hepatotoxic action of other xenobiotics such as diethylnitrosamine, Pb and As (Bingül et al, ; Choudhury et al, ; Kopeć et al, ; Winiarska‐Mieczan, ). It should be underlined that the beneficial properties of these compounds are widely used in the prevention and therapy of numerous diseases in humans, such as obesity, diabetes, cardiovascular diseases and cancer (Bozzetto et al, ; Henning et al, ; Hokayem et al, ; Rasines‐Perea & Teissedre, ; Tresserra‐Rimbau et al, ; Venancio et al, ).…”

“…According to their structure, molecular weight and hydroxylation patterns, polyphenols are divided into five major classes: phenolic acids, phenolic alcohols, flavonoids, stilbenes and lignans (Quideau et al, 2011 (Bingül et al, 2013;Brzóska, Rogalska, et al, 2015;Brzóska, Borowska, & Tomczyk, 2016;Brzóska, Rogalska, et al, 2016;Brzóska et al, 2017;Winiarska-Mieczan, 2015;Choudhury et al, 2016;Kopeć, Sikora, Piątkowska, Borczak, & Czech, 2016;Pang et al, 2016;Borowska et al, 2017). Moreover, in reference to representatives of particular groups of polyphenols there is evidence of their hepatoprotective abilities (Casalino et al, 2002;Eybl et al, 2006;Kowalczyk et al, 2003;Pang et al, 2016;Pari & Shagirtha, 2012).…”

Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements

“…Since high levels of ATO lead to generation of ROS in diverse cell types including HACAT, mouse skin fibroblasts and hepatocytes (Chayapong et al 2016;Choudhury et al 2016;Mir et al 2017), we also tested our new models for occurrence of ROS upon arsenic treatment. Indeed, even treatment with the lowest concentration of 0.05 µM ATO resulted in significantly increased ROS levels (Fig.…”