Pomegranate juice attenuates neurotoxicity and histopathological changes of the nervous system induced by aluminum in mice

Gadouche, Leila; Djebli, Noureddine; Zerrouki, Khayra

doi:10.3166/phyto-2018-0016

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…In our memory study, mice treated with AlCl 3 and Dgalactose had significantly decreased memory and learning capacity (P < 0.01), which was associated with the presence of degenerating neurons in the cerebral cortex, hippocampus, and cerebellum, as well as histo-morphological abnormalities. These results and findings are in accordance with those reported by Chiroma et al, [4,22] Zerrouki et al, [23] Gadouche et al, [24] and Yang et al. [25] The acetone fraction of P. edulis seeds (PEAS) results in a highly significant reduction in the number of repeated arms in mice treated with Alz-ED1 and Alz-ED2 as well as mice treated with Rivastigmine at 1 mg/kg when compared to Alzheimer's model mice (Alz) on various memory tests, including spatial working memory and the Morris water maze.…”

Section: Discussionsupporting

confidence: 93%

“…In our memory study, mice treated with AlCl 3 and D‐galactose had significantly decreased memory and learning capacity ( P< 0.01), which was associated with the presence of degenerating neurons in the cerebral cortex, hippocampus, and cerebellum, as well as histo‐morphological abnormalities. These results and findings are in accordance with those reported by Chiroma et al., [4,22] Zerrouki et al., [23] Gadouche et al., [24] and Yang et al. [25]…”

Section: Discussionsupporting

confidence: 93%

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Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies

Mostefa

Djebli

Khanh

et al. 2023

Chemistry & Biodiversity

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The stilbene-rich acetone fraction in high yield (6.6 %, PEAS) of Passiflora edulis Sims was prepared and evaluated for neuroprotective activity in murine Alzheimer's disease model induced by aluminum chloride and D-galactose. The phytochemical and HPLC-DAD-MS analysis of the polyphenolic stilbene-rich acetone fraction showed that it contained different stilbenes including trans-piceatannol, scirpusins AÀ B and cassigarol E. The total phenolic content (TPC) of PEAS was 413.87 � 1.71 mg GAE eqv/g. The neuroprotective activity of PEAS is typically presented in the Morris water maze-reference Spatial Memory test, where the Alzheimer's mice treated at 100 mg/kg (Alz-ED1) and 200 mg/kg (Alz-ED2) spent less than 47 % and 66 % of the time, respectively, than the Alzheimer's model mice (Alz). Two simple stilbenes, trans-piceatannol and trans-resveratrol, showed selectively inhibitory activity in silico against acetylcholinesterase (AChE). Two stilbene dimers, cassigarol E and scirpusin A, exhibited low nanomolar inhibitory potential against AChE and butyrylcholinesterase (BChE), significantly lower than those of the positive control, donepezil and tacrine. These findings suggest that the stilbenes from P. edulis seeds, particularly the stilbene dimers, warrant further investigation as potential neuroprotective candidates in the prevention of cognitive deficits associated with Alzheimer's disease.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies

Mostefa

Djebli

Khanh

et al. 2023

Chemistry & Biodiversity

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“…These results agree with Rashwan et al (2018) and show that the open field test reflects behavior related to exploratory activity and anxiety that are expressed in AlCl3intoxicated rats by reduced horizontal and vertical exploratory activity, high latency, and high defecation. Exposition to AlCl3 induces significant alterations in a number of motor functions and an increase in motor neuron apoptosis (Gadouche et al, 2018). However, administration of probiotics resulted in a marked improvement in locomotor activity in both intoxicated and treated rats, as well as improvement in their exploratory and emotional states, suggesting that the probiotic helps support the nervous systems and may help release emotional blockages and bring a sense of balance.…”

Section: Locomotor Activity (Open Field)mentioning

confidence: 99%

Prophylactic Effect of A Probiotic Strain Lactobacillus Rhamnosus Against Aluminum Chloride-Induced Intoxication in Wistar Rats: Neurobehavioral and Hematobiochemical Studies

Adli¹,

Benreguieg²,

Ziani³

et al. 2022

AGJSR

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Purpose: Aluminum (Al) and its various forms are environmental xenobiotics that pose great threats to public health. The probiotic strain has been reported to have important protective effects against aluminum cytotoxicity. Therefore, the current study was designed to assess the disruption of neurobehavioral and hematobiochemical parameters caused by chronic exposure to AlCl3, and then explore the protective effects of the probiotic strain Lactobacillus rhamnosus against these adverse in male rats. Method: Thirty-two animals were gathered into four groups: The first group served as control. The second group received 100mg AlCl3/kg bw for 12 weeks. However, the third group was administered 10mL probiotic strain /Kg (108 CFU/ml) bw/d daily for 4 weeks. Finally, group 4 received AlCl3 for 12 weeks, then the treatment was continued with probiotic for 4 weeks. Results: AlCl3 produced a decrease in body and brain weights with respect to their control. The results obtained also showed significant depression and anxiety-like behavior in the intoxicated animals, with a disturbance of the tested hematobiochemical parameters, particularly in renal and hepatic biomarkers. Overall, probiotics prevented enduring AlCl3-induced depression-like behavior in intoxicated rats. The results of the hematobiochemical, renal and hepatic analyses show a correction of the values after the administration of probiotics compared to those of intoxicated and untreated animals. Conclusion: The probiotic lactobacilli would be an alternative to reduce AlCl3 toxicity.

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“…High-performance liquid chromatography with a diode array detector (HPLCDAD) revealed a variety of bioactive molecules (luteolin, quercetin, and gallic acid) contained in pomegranate. They conclude that eating pomegranate may be neuroprotective for neuropathy caused by Al poisoning (Gadouche et al, 2018 ).…”

Section: Neurotoxicitymentioning

confidence: 99%

Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

Kazemabad

Toni

Tizro

et al. 2022

Front. Aging Neurosci.

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Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD] and Parkinson's disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it. Pomegranate (Punica granatum L.) is one of the polyphenol-rich fruits that is widely mentioned in medical folklore. Pomegranate is commonly used to treat common disorders such as diarrhea, abdominal pain, wound healing, bleeding, dysentery, acidosis, microbial infections, infectious and noninfectious respiratory diseases, and neurological disorders. In the current review article, we aimed to summarize the data on the pharmacotherapeutic potentials of pomegranate in ANDs.

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Pomegranate juice attenuates neurotoxicity and histopathological changes of the nervous system induced by aluminum in mice

Cited by 5 publications

References 36 publications

Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies

Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies

Prophylactic Effect of A Probiotic Strain Lactobacillus Rhamnosus Against Aluminum Chloride-Induced Intoxication in Wistar Rats: Neurobehavioral and Hematobiochemical Studies

Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

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