Polyvinylpyrrolidone-iodine as a control for infectious pancreatic necrosis of brook trout

Economon, Philip P.

doi:10.1080/03680770.1973.11899656

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Iodine added at low concentrations to the water was also effective in the prevention of IHNV infection in rainbow trout (Batts et al . 1991), and different studies have reported the properties of iodine complexes that destroy fish viruses, such as IHNV, IPNV and VHSV (Amend & Pietsch 1972; Elliott & Amend 1978). Currently, PVP‐I is routinely used in aquaculture to disinfect egg surfaces (Cipriano et al .…”

Section: Pharmacological Drugs Directed To Different Steps Of the Viral Cyclementioning

confidence: 99%

“…One of the first antiviral compounds used in aquaculture was poly(vinylpyrrolidone)-iodine (PVP-I), which is a broad-spectrum antiseptic that blocks viral attachment to cellular receptors and also inhibits viral release and spread from infected cells (Sriwilaijaroen et al 2009). Economon (1963Economon ( , 1973 observed a reduction in the morbidity and mortality caused by IPNV in brook trout (Salvelinus fontinalis) when the animals were fed PVP-I. Iodine added at low concentrations to the water was also effective in the prevention of IHNV infection in rainbow trout (Batts et al 1991), and different studies have reported the properties of iodine complexes that destroy fish viruses, such as IHNV, IPNV and VHSV (Amend & Pietsch 1972;Elliott & Amend 1978).…”

Section: Inhibitors Of Viral Attachment Entry and Uncoatingmentioning

confidence: 99%

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Compilation of antiviral treatments and strategies to fight fish viruses

Pereiro

Figueras

Novoa

2020

Reviews in Aquaculture

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The implementation of antiviral treatments and prophylaxis strategies in fish aquaculture needs to be established. The absence of commercial vaccines for most viral diseases affecting economically relevant fish species, and the total lack of treatments to fight these diseases once they have emerged in a fish farm remains one of the main bottlenecks in fish aquaculture production. However, although no antivirals are currently applied on farms, a great number of investigations have been conducted to assess the potential use of antiviral treatments against several fish viruses. Although most of these works were based on in vitro approaches, some included in vivo experiments to demonstrate the potential applicability of these treatments. This review summarizes the investigations conducted both in vitro and in vivo in the field of antiviral treatments against fish viruses. The highlighted works include those using piscine and non-piscine proteins with antimicrobial functions, metabolites, chemical compounds (some of which are used in medicine to treat human viruses), bioactive compounds mainly isolated from plants and bacteria, and emerging DNA-and RNA-based therapeutics. This information can be used for developing both specific and broad-spectrum antiviral strategies to be further used in the aquaculture industry, and it may even provide interesting indications for biomedical research.

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Section: Pharmacological Drugs Directed To Different Steps Of the Viral Cyclementioning

confidence: 99%

Section: Inhibitors Of Viral Attachment Entry and Uncoatingmentioning

confidence: 99%

Compilation of antiviral treatments and strategies to fight fish viruses

Pereiro

Figueras

Novoa

2020

Reviews in Aquaculture

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“…SUbsequent studies to determine the optimum dose regimen were not reported until 10 years later (Economon, 1973). Brook trout fry were given PVP-I treated diet for 15 days to give an estimated intake of 1.64 available iodine kg day", A mortality of 17% was observed in the treated fish compared with 34% mortality in the untreated controls.…”

Section: Piscine Virusesmentioning

confidence: 99%

Prospects for Antiviral Chemotherapy in Veterinary Medicine: 2. Avian, Piscine, Canine, Porcine, Bovine and Equine Virus Diseases

Rollinson¹

1992

Antivir Chem Chemother

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SummaryThis paper, which is published in two parts, reviews the literature pertaining to antiviral chemotherapy of viruses of veterinary importance. While early reports in the 1970s referred to the chemotherapy of a number of different RNA and DNA viruses, there' was considerable focus in the 1980s, initially on herpesviruses and latterly on retroviruses, and particularly in cats. Details are given of the successful treatments of FeLV and FIV, which have been used as animal models for HIV therapy. 'Therapy of equine, canine, bovine, porcine, avian, and fish diseases is also considered. The high costs of developing and registering a new chemical entity, especially for food species in which extensive toxicity/residue data are required, is the main reason why specific antiviral compounds are not currently available for veterinary use, although some non-specific immune modulators are now emerging. Concurrent availability of appropriate diagnostic tools is a prerequisite for successful veterinary antiviral chemotherapy, as is a greater understanding of the pathogenesis of virus infections in animals and the development of more sophisticated means of drug delivery, appropriate to both food animal species and companion animals (dogs, cats, and horses). Additionally, antiviral agents are valuable as research tools per se, as opposed to solely as chemotherapeutic agents. Part 1 covers the feline virus diseases, while part 2 includes the other viruses~f veterinary importance, in dogs, horses, cattle, pigs, birds, and fish.

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Invisible plastics problem in intensive aquaculture: The case of polyvinylpyrrolidone

Robison‐Smith,

Cable

2024

Reviews in Aquaculture

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For over 70 years, aquaculture practices have relied on the same methods for biosecurity, however epidemics remain a primary limitation of global aquaculture yields with billions in revenue being lost every year due to disease. The intense nature of fish and shellfish farming necessitates the regular use of synthetic chemicals as both preventive and treatment measures, covering broodstocks to hatching and continuing through all stages of rearing. This practice, however, results in the contamination of rearing environments with persistent xenobiotics. A specific drawback in this foundational strategy for aquaculture biosecurity is highlighted in the current review: the consistent use of a water‐soluble polymer polyvinylpyrrolidone (PVP) across most, if not all, stages of rearing aquacultural livestock. PVP is used intensively within aquaculture practices as it is a ubiquitous additive within commercially available germicidal, prophylactic, and therapeutic products applied to control and prevent disease outbreaks within aquacultural farms. As a polymer, PVP is synthetic and biodegradation‐resistant, and has recently been described as an emerging contaminant of freshwater ecosystems. It is well documented that other persistent, synthetic polymer pollutants such as microplastics, reduce the fecundity, growth, and significantly deplete immune function in commercially important aquatic species. Despite this, intentionally added persistent soluble polymers, such as PVP, have not been considered in the context of aquaculture productivity. This review explores the potential impact of PVP on fish and shellfish highlighting the need for aquaculture to adopt sustainable chemical practices, drawing inspiration from advancements in nanotechnology applied within human medicines to address biosecurity protocol deficiencies.

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Polyvinylpyrrolidone-iodine as a control for infectious pancreatic necrosis of brook trout

Cited by 3 publications

References 5 publications

Compilation of antiviral treatments and strategies to fight fish viruses

Compilation of antiviral treatments and strategies to fight fish viruses

Prospects for Antiviral Chemotherapy in Veterinary Medicine: 2. Avian, Piscine, Canine, Porcine, Bovine and Equine Virus Diseases

Invisible plastics problem in intensive aquaculture: The case of polyvinylpyrrolidone

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