Polyvinyl alcohol/Gum tragacanth/graphene oxide composite nanofiber for antibiotic delivery

Abdoli, Mohadese; Sadrjavadi, Komail; Arkan, Elham; Zangeneh, Mohammad Mahdi; Moradi, Sajad; Zangeneh, Akram; Shahlaei, Mohsen; Khaledian, Salar

doi:10.1016/j.jddst.2020.102044

Cited by 49 publications

(19 citation statements)

References 29 publications

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“…This polymer is a biocompatible, biodegradable, and non-toxic polymer; it is a carrier for medication and has a good chemical and biological resistance, high tensile strength, hydrophilicity, and high ability to form fibers [ 9 ]. Different composite nanofibers of PVA with natural structure such as gum [ 32 ], chitosan [ 33 ], cellulose [ 34 ], collagen [ 35 ], and keratin [ 36 ] have been fabricated by the electrospinning method in order to improve mechanical properties, electrospinability, tensile strength, and chemical resistance of biopolymers [ 37 ]. Nano-structures such as nano-films from PVA and kefiran polymer mixtures have been also synthesized [ 38 ]; yet, a study on the preparation of kefiran/PVA composite nanofibers was conducted by our research group for the first time promising to introduce novel antibacterial and antiviral coating and films based on kefiran nanofibers for application in the medicine, drug, and food industries especially milk packaging industry [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

An investigation of factors affecting the electrospinning of poly (vinyl alcohol)/kefiran composite nanofibers

Ziyadi

Baghali

Bagherianfar

et al. 2021

Adv Compos Hybrid Mater

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Graphical abstract This study aimed to investigate parameters affecting the electrospinning of poly (vinyl alcohol) (PVA)/kefiran composite nanofibers. Accordingly, PVA/kefiran composite nanofibers were produced using the electrospinning of PVA, kefiran blend solutions under various electrospinning parameters (such as applied voltage, nozzle-to-collector distance, and polymer injection rate), and solution parameters (such as the ratio of polymers). PVA and kefiran solutions were prepared in 8% and 6% w/w, respectively. Kefiran was blended with PVA solution in different proportions: 70:30, 60:40, 50:50, 40:60, and 30:70. According to the scanning electron microscope (SEM) images, kefiran mixed with PVA in 40:60 ratios produced the best result in nanofiber production. Then, device parameters such as voltage (12, 15, 18, and 20 kV), distance (120, 150, 170, and 200 mm), and polymer injection rates (1, 1.5, 2, and 2.5 mL/h) were changed. The investigation of SEM images showed that the optimal condition for the fabrication of nanofibers was 18 kV, 200 mm, and 1 mL/h. The nanofibers produced in the optimal condition were uniform without knots or adhesion in a small diameter. It was also found that concentration can be regarded as the most effective parameter affecting the diameter of nanofibers. Moreover, the transmission electron microscopy (TEM) image proved that phase separation did not occur between the two polymers. Kefiran biopolymer extracted from fermented milk was used in fabrication of PVA/kefiran composite nanofibers using the electrospinning method.

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Section: Introductionmentioning

confidence: 99%

An investigation of factors affecting the electrospinning of poly (vinyl alcohol)/kefiran composite nanofibers

Ziyadi

Baghali

Bagherianfar

et al. 2021

Adv Compos Hybrid Mater

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“…NPCs were protected from apoptosis, and tau phosphorylation was decreased due to the composite activity . A novel drug delivery system consisting of polyvinyl alcohol and gum tragacanth combined with tetracycline containing graphene oxide and tetracycline hydrochloride (TCH) has been established for transdermal applications . As shown in previous cases, the inclusion of GO improved the tensile strength of the fibres.…”

Section: Drug and Gene Deliverymentioning

confidence: 92%

Biomedical Applications of Electrospun Graphene Oxide

Grant

Pillai

Hehir

et al. 2021

ACS Biomater. Sci. Eng.

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Graphene oxide (GO) has broad potential in the biomedical sector. The oxygen-abundant nature of GO means the material is hydrophilic and readily dispersible in water. GO has also been known to improve cell proliferation, drug loading, and antimicrobial properties of composites. Electrospun composites likewise have great potential for biomedical applications because they are generally biocompatible and bioresorbable, possess low immune rejection risk, and can mimic the structure of the extracellular matrix. In the current review, GO-containing electrospun composites for tissue engineering applications are described in detail. In addition, electrospun GO-containing materials for their use in drug and gene delivery, wound healing, and biomaterials/medical devices have been examined. Good biocompatibility and anionic-exchange properties of GO make it an ideal candidate for drug and gene delivery systems. Drug/gene delivery applications for electrospun GO composites are described with a number of examples. Various systems using electrospun GO-containing therapeutics have been compared for their potential uses in cancer therapy. Micro- to nanosized electrospun fibers for wound healing applications and antimicrobial applications are explained in detail. Applications of various GO-containing electrospun composite materials for medical device applications are listed. It is concluded that the electrospun GO materials will find a broad range of biomedical applications such as cardiac patches, medical device coatings, sensors, and triboelectric nanogenerators for motion sensing and biosensing.

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“…The molecular dispersion of the drug in the polymeric fibre promotes better solubility as well as it is supported by the higher specific area due to the nanofibre surface structure. 52,53 This delivery system is considered to be suitable for delivering the poorly watersoluble polyphenol, e.g., RSV or PTS. 54 Polymer is the main key for this formulation.…”

Section: Electrospun Nanofibrementioning

confidence: 99%

Antioxidant activity and nano delivery of the most frequently applied stilbene derivatives: A brief and recent review

Choiri¹,

Fitriastuti²,

Faradiva³

et al. 2021

Pharm Sci

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As of recent, the appearance rate of several degenerative diseases and cancer influenced by oxidative stress continues to increase dramatically. Many compounds with high potential antioxidant activity have been explored and used extensively, i.e., as preventive or curative treatments. Stilbene and its derivates have high potential antioxidant activity contained in several botanical sources. To date, source exploration and antioxidant activity study of stilbene derivate has been reported. However, the nano-delivery of stilbene derivate meant to increase the antioxidant activity and stability is still a limited process. This review is devoted to brief and recent outlooks regarding the antioxidant activity and delivery system of the most frequently applied stilbene and its derivates, namely resveratrol and pterostilbene.

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Polyvinyl alcohol/Gum tragacanth/graphene oxide composite nanofiber for antibiotic delivery

Cited by 49 publications

References 29 publications

An investigation of factors affecting the electrospinning of poly (vinyl alcohol)/kefiran composite nanofibers

An investigation of factors affecting the electrospinning of poly (vinyl alcohol)/kefiran composite nanofibers

Biomedical Applications of Electrospun Graphene Oxide

Antioxidant activity and nano delivery of the most frequently applied stilbene derivatives: A brief and recent review

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