Polyurethanes in Biomedical Applications

Lamba, N. M. K.; Woodhouse, Kimberly A.; Cooper, Stuart L.

doi:10.1201/9780203742785

Cited by 90 publications

(127 citation statements)

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“…The susceptibility of PUs to biodegradation lies in soft segment components of the polymer. These segments generally dominate the degradation characteristics of PUs, with higher properties of soft segments tending to correlate with increased degradation rate [38]. The isosorbide gives higher hydrophilicity to the PU segment than that of does PCD unit with haxamethylene moiety, making hydrolytic attack easier.…”

Section: In Vitro Degradation Testmentioning

confidence: 99%

Synthesis of bio-based thermoplastic polyurethane elastomers containing isosorbide and polycarbonate diol and their biocompatible properties

Kang

Knowles³

et al. 2015

J Biomater Appl

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A new family of highly elastic polyurethanes (PUs) partially based on renewable isosorbide were prepared by reacting hexamethylene diisocyanate with a various ratios of Is and polycarbonate diol 2000 (PCD), via a one-step bulk condensation polymerization without catalyst. The influence of the isorsorbide/PCD ratio on the properties of the polyurethane was evaluated. The successful synthesis of the polyurethanes was confirmed by Fourier transform-infrared spectroscopy and 1 H nuclear magnetic resonance. The resulting PUs showed high number-average molecular weights ranging from 56,320 to 126,000 g mol -1 and tunable Tg values from -34 to -38°C. The thermal properties were determined by differential scanning calorimetry and thermogravimetric analysis. The PU films were flexible with breaking strains from 955% to 1795% at from 13.5 to 54.2 MPa tensile stress. All the polyurethanes had 0.9-2.8% weight lost over 4 weeks and continual slow weight loss of 1.1-3.6% was observed within 8 weeks. Although the cells showed a slight lower rate of proliferation than that of the tissue culture polystyrene as a control, the polyurethane films were considered to be cytocompatible and nontoxic. These thermoplastic polyurethanes were soft, flexible and biocompatible polymers, which open up a range of opportunities for soft tissue augmentation and regeneration.

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Section: In Vitro Degradation Testmentioning

confidence: 99%

Synthesis of bio-based thermoplastic polyurethane elastomers containing isosorbide and polycarbonate diol and their biocompatible properties

Kang

Knowles³

et al. 2015

J Biomater Appl

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“…SMPU-laminated fabric produces a smart fabric with excellent properties (waterproof, windproof, and breathable) [ 75 , 76 ]. Smart PU combines excellent mechanical properties with good blood compatibility, which favors their use and development as biomaterials, particularly as components for implanted devices [ 4 ]. SMPUs also have tremendous applications in other biomedical devices such as smart sutures, vascular stents, and micro-actuator for blood vessel clots and cardiovascular dent applications [ 77 ].…”

Section: Potential Application Of Smart Polyurethanementioning

confidence: 99%

Polyurethane-Based Smart Polymers

Zain

Zubir

2016

Industrial Applications for Intelligent Polymers and Coatings

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Polyurethane is a highly versatile polymer that may be used in various types of applications with a wide range of properties. The combination of different types and ratios of isocyanate and polyol allows for the control of the desired end properties. Due to its unique properties, it has found applications in the fi elds of medical, military, automobile, and aerospace industries. Recently, there has been a prodigious interest in producing polyurethane-based smart polymers, especially shape memory polyurethane (SMPU). This is due to its excellent ability to change shape upon the application of external stimuli such as heat, electric fi eld, magnetic fi eld, and light. The existence of phase-separated structure known as soft-and hard-segment domains contributes toward the shape memory properties of polyurethane. The soft-segment domains are responsible for maintaining the temporary shape, while hard segments fi x the permanent shape. This chapter comprehensively aims to address a wide overview of polyurethane-based smart polymer and the chemistry behind the shape memory properties. In addition, this chapter also summarizes the recent studies on the exploration of SMPU using vegetable oils along with petroleum-based polyol and the potential applications of smart polyurethane.

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“…Polyurethanes are the most abundant polymeric materials which have versatile properties suitable for medical applications due to their extreme biocompatibility and mechanical properties (Lamba et al 1998;Zdrahala and Zdrahala 1999). Polyurethanes are synthesized from the reaction of polyols with derivatives of petroleum multi-isocyanate, both of which could be derived from triglycerides and their derivatives (More et al 2013).…”

Section: Synthesis Of Multi-isocyanatesmentioning

confidence: 99%

Green Synthesis of Polymer Composites/Nanocomposites Using Vegetable Oil

Roopan

Madhumitha

2015

Advanced Structured Materials

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Vegetable triglycerides are among the first renewable resources exploited by man primarily in coating applications because their unsaturated varieties polymerize as thin films in the presence of atmospheric oxygen. Nowadays, use of the vegetable oils is spotlight of the chemical industries and as they are using these as a renewable platform for further ability. In order to overcome disadvantages such as poor mechanical properties of polymers from renewable resources, or to offset the high price of synthetic biodegradable polymers, various blends and composites have been developed over the last decade. The progress of blends from three kinds of polymers from renewable resources (1) natural polymers, such as starch, protein, and cellulose; (2) synthetic polymers from natural monomers, such as polylactic acid; and (3) polymers from microbial fermentation. In this chapter we have discussed about the different types of polymer composites obtained from the vegetable oil and applications of the polymer composites.

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Polyurethanes in Biomedical Applications

Cited by 90 publications

References 0 publications

Synthesis of bio-based thermoplastic polyurethane elastomers containing isosorbide and polycarbonate diol and their biocompatible properties

Synthesis of bio-based thermoplastic polyurethane elastomers containing isosorbide and polycarbonate diol and their biocompatible properties

Polyurethane-Based Smart Polymers

Green Synthesis of Polymer Composites/Nanocomposites Using Vegetable Oil

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