Polyurethane-silica hybrid foams from a one-step foaming reaction, coupled with a sol-gel process, for enhanced wound healing

Song, Eun Ho; Jeong, Seol Ha; Park, Ji Ung; Kim, Suk Wha; Kim, Hyoun Ee; Song, Jiajia

doi:10.1016/j.msec.2017.05.041

Cited by 40 publications

(32 citation statements)

References 46 publications

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“…11,12 However, HA do not show any intrinsic bioactivity, and do not induce positive regenerative response from bone cells when implanted. [15][16][17] For getting the more credible evidence of biocompatibility and potential application of the hybrids, it is necessary to address the bioreactivities of these hybrids in vivo. A hybrid interconnected organic-inorganic structure, polycaprolactone-hydroxyapatite composites, has been reported to be a promising scaffold for bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO₂ and chitosan/SiO₂/hydroxyapatite hybrids

Guo

Dong

Xiao

et al. 2018

J Biomedical Materials Res

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Inorganic/organic hybrid silica-chitosan (CS) scaffolds have promising potential for bone defect repair, due to the controllable mechanical properties, degradation behavior, and scaffold morphology. However, the precise in vivo immuno-reactivity of silica-CS hybrids with various compositions is still poorly defined. In this study, we fabricated the three-dimensional (3D) interconnected porous chitosan-silica (CS/SiO ) and chitosan-silica-hydroxyapatite (CS/SiO /HA) hybrids, through sol-gel process and 3D plotting skill, followed by the naturally or freeze drying separately. Scanning electron microscopy demonstrated the hybrids possessed the uniform geometric structure, while, transmission electron microscopy displayed nanoscale silica, or HA nanoparticles dispersed homogeneously in the CS matrix, or CS/silica hybrids. After intramuscular implantation, CS/SiO and CS/SiO /HA hybrids triggered a local and limited monocyte/macrophage infiltration and myofiber degeneration. Naturally dried CS/SiO hybrid provoked a more severe inflammation than the freeze-dried ones. Dendritic cells were attracted to invade into the implants embedded-muscle, but not be activated to prime the adaptive immunity, because the absence of cytotoxic T cells and B cells in muscle received the implants. Fluorescence-activated cell sorting (FACS) analysis indicated the implanted hybrids were incapable to initiate splenocytes activation. Plasma complement C3 enzyme linked immunosorbent assay (ELISA) assay showed the hybrids induced C3 levels increase in early implanting phase, and the subsequent striking decrease. Thus, the present results suggest that, in vivo, 3D plotted porous CS/SiO and CS/SiO /HA hybrids are relatively biocompatible in vivo, which initiate a localized inflammatory procedure, instead of a systematic immune response. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1223-1235, 2018.

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Section: Introductionmentioning

confidence: 99%

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO₂ and chitosan/SiO₂/hydroxyapatite hybrids

Guo

Dong

Xiao

et al. 2018

J Biomedical Materials Res

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“…Promising results in chronic wounds care are also associated with other polysaccharide-based hydrogels, such as chitosan [26], hyaluronan [27] and dextran [28]. Similar properties are found in the case of foams that can be applied to wounds with medium exudates [29,30]. An attractive approach in modern wound care is the combination between healing dressings and antimicrobial agents.…”

Section: Wound Care and Dressingsmentioning

confidence: 87%

The importance of oxygen release in diabetic foot ulcer wounds

2019

Bioengineering Int

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Oxygen is the essential element required for proper physiological function of cells, tissues and organs within healthy human body. Thanks to its intricate structure, the skin provides a multiprotective barrier against traumatic and non-traumatic injuries, but also a complex and successful self-healing process of the affected tissue. In the particular case of chronic skin wounds, such as diabetic foot ulcer wounds, there is an immediate demand to develop alternative procedures that prevent infection, speed up healing and eliminate any disrupting factor that may interfere with the therapeutic process. Given the importance of oxygen during wound healing cascade, impressive attention was oriented towards the fabrication of oxygen-releasing wound dressings.

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“…58 Breathability and adhesion strength in these materials have been improved using different crosslinkers by Singh et al 58 PU-dressing foams offer excellent water absorption, optical mechanical properties and cost effective, but have low bioactivity and poor healing capability; incorporation of bioactive silica nanoparticles during the sol-gel process improved wound-closure rates and accelerated collagen and elastin fibre regeneration. 59 Morgado et al also reported a modified crosslinked PU hydrogel, which absorbed large quantities of water without dissolving. This property is useful for wound healing dressings where an asymmetric membrane made of a PEG polyol prevents the rapid dehydration of the wound surface and penetration of bacteria.…”

Section: Surgical Dressings/pressure Sensitive Adhesivesmentioning

confidence: 99%

Biomedical applications of polyurethane materials and coatings

Joseph

Patel

Wenham

et al. 2018

Transactions of the IMF

130

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Polyurethanes (PUs), formed by the reaction of diisocyanates with polyols (or equivalent) in the presence of a catalyst, have a wide variety of industrial uses. Much recent attention has focused on their biomedical applications, owing to their biocompatibility, biodegradability and tailorable chemical and physical forms. Examples of such application areas include antibacterial surfaces and catheters, drug delivery vehicles, stents, surgical dressings/pressure sensitive adhesives, tissue engineering scaffolds and electrospinning, nerve generation, cardiac patches and PU coatings for breast implants. Following a brief introduction to PUs, this review surveys selected articles, mostly from 2014 to 2017, that highlight this diverse range of biomedical applications offered by PU materials and coatings.

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Polyurethane-silica hybrid foams from a one-step foaming reaction, coupled with a sol-gel process, for enhanced wound healing

Cited by 40 publications

References 46 publications

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO₂ and chitosan/SiO₂/hydroxyapatite hybrids

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO₂ and chitosan/SiO₂/hydroxyapatite hybrids

The importance of oxygen release in diabetic foot ulcer wounds

Biomedical applications of polyurethane materials and coatings

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Polyurethane-silica hybrid foams from a one-step foaming reaction, coupled with a sol-gel process, for enhanced wound healing

Cited by 40 publications

References 46 publications

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO2 and chitosan/SiO2/hydroxyapatite hybrids

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO2 and chitosan/SiO2/hydroxyapatite hybrids

The importance of oxygen release in diabetic foot ulcer wounds

Biomedical applications of polyurethane materials and coatings

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Product

Resources

About

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO₂ and chitosan/SiO₂/hydroxyapatite hybrids

In vivo immuno‐reactivity analysis of the porous three‐dimensional chitosan/SiO₂ and chitosan/SiO₂/hydroxyapatite hybrids