Polyurethane anionomers containing metal ions with antimicrobial properties: Thermal, mechanical and biological characterization

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

“…The microphase structure of the polyurethane can be changed by the introduction of functional and/or ionic groups into the polymer chains. For example, ionic groups can interact electrostatically, contributing to the structural arrangement of the segmented polyurethane [21], and consequently altering mechanical properties and solubility [56]. However, according to the obtained SAXS results, the incorporation of TA into polyurethane did not lead to significant changes in the natural phase-separated structure of the polymer, suggesting that the drug was present within the polyurethane as isolated crystals.…”

“…The microphase separation was due to the incompatibility between the hard and soft segments. Polar groups such as urethane in hard segments can hydrogen bond to each other to favor the formation of hard domains [21,55]. The microphase structure of the polyurethane can be changed by the introduction of functional and/or ionic groups into the polymer chains.…”

“…They would provide transport and controlled release of a therapeutic agent at the target site to treat or prevent different types of diseases [17][18][19]. Moreover, polyurethane-based systems can lead to a prolonged and controlled release of antimicrobial drugs [20][21][22], for antiseptic activity. Polyurethane intravaginal rings were produced to favor sustained release of antiretroviral agents to prevent the male-to-female sexual transmission of HIV [23,24].…”

Synthesis and characterization of antibacterial polyurethane coatings from quaternary ammonium salts functionalized soybean oil based polyols

“…This approach provides several advantages, including avoiding the release of biocides into the environment, prolonged service time of coating and increased antibacterial efficiency/selectivity arising from high local concentration of biocides at the surface of materials [1][2][3][4]. Bonding of biocidal functional moieties to the preformed polymers [20][21][22] or synthesis of biocidal functional monomers and their subsequent polymerization [23][24][25][26] are two main approaches considered for the preparation of such active polymeric coatings.…”

Water state effect on drug release from an antibiotic loaded polyurethane matrix containing albumin nanoparticles

“…Different functional groups, introduced in principal or side chain of the segmented polyurethane, have been already exploited by our group to bind bioactive molecules, like heparin (Marconi et al, 1992(Marconi et al, , 1993, or antibiotics (Piozzi et al, 2004b;Ruggeri et al, 2007) or silver ions (Francolini et al, 2006(Francolini et al, , 2010. However, it was observed that in these systems only the antibiotic adsorbed on the polymer surface was released.…”