Polyunsaturated fatty acids and signalling via phospholipase C-β and A2 in myocardium

Jonge, Henriëtte W. de; Dekkers, Dick H. W.; Lamers, Jos M. J.

doi:10.1007/978-1-4613-1275-8_25

Cited by 3 publications

(3 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary fish oil supplementation has been shown to reduce progression of renal disease among patients with IgA nephropathy [56] and to suppress mesangial cell activation and proliferation in animal models [60]. PUFA may reduce inflammation through several possible pathways, such as reduction of nitric oxide [61], down-regulation of TNF-α [62], and modulation of protein kinases [63]. …”

Section: Evidence Of Treatment By Omega-3 Of the Specific Kidney Disementioning

confidence: 99%

Omega-3 and Renal Function in Older Adults

Lauretani

Maggio²,

Pizzarelli

et al. 2009

CPD

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a major public health problem and can result in end-stage renal disease with need for dialysis or transplantation. In Europe up to 12% of the adult population had some renal impairment, while in the United States the end stage of CKD has increased dramatically from 209.000 in 1991 to 472.000 in 2004. Diabetes and hypertension are major causes of kidney pathology. Infection, particularly ascending infection, is more common with increasing age, as both immune function declines and associated pathology predisposing to infection, such as obstructive uropathy, becomes more common. Most pathological changes in the kidney appear to be initiated by oxidative stress, followed by an inflammatory reaction. Oxidative stress results from an imbalance between free radicals and their detoxification by endogenous and exogenous scavengers, including polyunsatured fatty acids (PUFA). Recent studies showed that PUFA supplementation slowed the rate of loss of renal function in patients with IgA nephropathy. Then, studies of omega-3 supplementation in dialysis patients describe salutary effects on triglyceride levels and dialysis access patency. We examined the relationship between total plasma PUFA levels and change in creatinine clearance over a three-year follow-up in the older persons enrolled in the InCHIANTI study, a population-based epidemiology study conducted in Tuscany, Italy. This study showed that older adults with low total plasma PUFA levels have a greater decline in creatinine clearance over three years of follow-up. These findings suggest that a higher dietary intake of PUFA may be protective against progression to chronic kidney disease.

show abstract

Section: Evidence Of Treatment By Omega-3 Of the Specific Kidney Disementioning

confidence: 99%

Omega-3 and Renal Function in Older Adults

Lauretani

Maggio²,

Pizzarelli

et al. 2009

CPD

View full text Add to dashboard Cite

show abstract

“…Among the mechanisms invoked to explain the n -3 PUFA inhibitory effect on cellular growth is their ability to modulate the activity of component of intracellular signaling (i.e., protein kinases, eicosanoids, reactive oxygen species, etc.) (4,(12)(13)(14). It is well known that Ca 2ϩ is an essential component in the signaling pathways evoking key cellular processes including cell proliferation and growth (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…We recently suggested that the enhancement of ␤ -oxidation activity by n-3 PUFAs and the consequent overproduction of H 2 O 2 may originate a mild oxidative stress able to inhibit neoplastic growth (4). Finally, different studies have reported that n-3 PUFAs can modulate the activity of components of intracellular signaling (12)(13)(14). It is well established that Ca 2 ϩ is among the major intracellular factors involved in the signaling transduction pathways evoking cell growth and proliferation, and other key processes such as gene expression, contraction, secretion, and cellular metabolism (15,16).…”

mentioning

confidence: 99%

n–3 PUFA dietary supplementation inhibits proliferation and store-operated calcium influx in thymoma cells growing in Balb/c mice

Calviello

Palozza

Nicuolo

et al. 2000

Journal of Lipid Research

View full text Add to dashboard Cite

The antitumor effect of daily individual administration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (2 g/kg body weight) in Balb/c mice bearing a transplantable thymoma was investigated. Mice received oleic acid (control group), EPA and DHA ethyl esters starting 10 days before tumor inoculation. Analysis of phospholipid composition of neoplastic cell revealed that EPA and DHA levels were significantly increased (63 and 22% increase) after EPA and DHA treatments, respectively. Conversely, decreased levels of arachidonic acid were found in both cases (19 and 24% decrease in EPA and DHA groups, respectively). EPA and DHA delayed the appearance of macroscopic ascites (100% of animal, from 7 to 28 days), prolonged animal survival (100% of animal, from 22 to 32 and 33 days, respectively) and reduced the percentage of proliferating tumor cells detected by immunostaining of proliferation cell nuclear antigen (PCNA) (80 and 85% decrease, respectively). Moreover, the regulatory effects of these dietary n-3 fatty acids on the influx of Ca 2 ؉ , activated by depletion of intracellular stores with thapsigargin (Tg), were investigated. By using a Ca 2 ؉ -free/Ca 2 ؉ -reintroduction protocol and Fura-2 as fluorescent indicator of intracellular free Ca 2 ؉ ([Ca 2 ؉ ] i ), we observed that EPA and DHA treatments markedly decreased Tg-induced rise in [Ca 2 ؉ ] i (49 and 37% decrease, respectively). This effect was related to the inhibition of the store-operated Ca 2 ؉ influx, as confirmed also by Mn 2 ؉ influx experiments. The inhibitory action of EPA and DHA on the store-operated Ca 2 ؉ influx could explain, at least in part, their antitumoral activity, as this Ca 2 ؉ mobilization pathway appears to be involved in the cell signaling occurring in non-excitable cells to evoke many cellular processes, including cell proliferation. -Calviello, G., P. Palozza, F. Di Nicuolo, N. Maggiano, and G. M. Bartoli. N-3 PUFA dietary supplementation inhibits proliferation and store-operated calcium influx in thymoma cells growing in Balb/c mice.

show abstract

Association Between Serum Long-Chain n-3 and n-6 Polyunsaturated Fatty Acid Profiles and Glomerular Filtration Rate Assessed by Serum Creatinine and Cystatin C Levels in Japanese Community-Dwellers

Higashiyama

Kubota

Marumo

et al. 2015

Journal of Epidemiology

View full text Add to dashboard Cite

BackgroundPlasma concentration of n-3 polyunsaturated fatty acids (PUFAs) has been reported to be associated with renal function in Western populations. However, few studies have investigated the association between serum long-chain n-3 and n-6 PUFA profiles and renal function in a Japanese population with high marine-derived long-chain n-3 PUFA intake.MethodsA cross-sectional study was performed in 549 Japanese rural community-dwellers aged 40 to 64 years. In adjusted analysis of covariance, we assessed the relationship between estimated glomerular filtration rate (eGFR) and tertiles of serum long-chain n-3 and n-6 PUFA profiles ([eicosapentaenoic acid {EPA} + docosahexaenoic acid {DHA}]:arachidonic acid [AA]). GFR was estimated by Japanese specific equations using serum creatinine and cystatin C (eGFRcre and eGFRcys). Using multivariate-adjusted linear regression models, we also assessed the relationships between eGFRs and several n-3 and n-6 PUFAs, which have been suggested to be associated with renal function.ResultsIn all participants, higher dietary fish intake as assessed by a semi-quantitative questionnaire was associated with higher serum value of (EPA+DHA):AA. Participants in the higher (EPA+DHA):AA tertiles had non-significantly higher eGFRcre and significantly higher eGFRcys (P = 0.016). In addition, eGFRcys in T2+T3 of (EPA+DHA):AA was significantly higher than that in T1 (adjusted mean eGFRcys, T1: 87 ml/min/1.73 m2, T2+T3: 91 ml/min/1.73 m2; P < 0.01). Among the PUFAs, only (EPA+DHA) was significantly associated with eGFRcys.ConclusionsSerum (EPA+DHA):AA, which reflects an individual’s fish intake, might be associated with eGFRcys in Japanese community-dwellers.

show abstract

Polyunsaturated fatty acids and signalling via phospholipase C-β and A2 in myocardium

Cited by 3 publications

References 67 publications

Omega-3 and Renal Function in Older Adults

Omega-3 and Renal Function in Older Adults

n–3 PUFA dietary supplementation inhibits proliferation and store-operated calcium influx in thymoma cells growing in Balb/c mice

Association Between Serum Long-Chain n-3 and n-6 Polyunsaturated Fatty Acid Profiles and Glomerular Filtration Rate Assessed by Serum Creatinine and Cystatin C Levels in Japanese Community-Dwellers

Contact Info

Product

Resources

About