Polysorbate 80 coated crosslinked chitosan nanoparticles of ropinirole hydrochloride for brain targeting

Ray, Somasree; Sinha, Pratyusha; Laha, Bibek; Maiti, Sabyasachi; Bhattacharyya, Uttam Kumar; Nayak, Amit Kumar

doi:10.1016/j.jddst.2018.08.016

Cited by 104 publications

(23 citation statements)

References 39 publications

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“…For this purpose, different concentrations of sample 1 and 3 (0.1, 0.2, 0.3, 0.4 and 0.5) were exposed to RBC for a specific time, and then the percentage of hemolysis of each sample was determined by UV-Vis spectrophotometer. Both of the samples show the hemolytic activity of less than 1 percent (Figure 12), revealing that they have no hemolytic effect on RBC and thus it could be considered that they are hemocompatible (according to the American Society for Testing and Materials (ASTM F 756–00, 2000)) 56,57Figure 12Hemolysis results of sample 1 and sample 3.…”

Section: Resultsmentioning

confidence: 99%

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

Zarepour

Zarrabi

Larsen

2019

IJN

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Background Fabrication of a smart drug delivery system that could dramatically increase the efficiency of chemotherapeutic drugs and reduce the side effects is still a challenge for pharmaceutical researchers. By the emergence of nanotechnology, a huge window was opened towards this goal, and a wide type of nanocarriers were introduced for delivering the chemotherapeutic to the cancer cells, among them are cyclodextrins with the ability to host different types of hydrophobic bioactive molecules through inclusion complexation process. Aim The aim of this study is to design and fabricate a pH-responsive theranostic nanocapsule based on cyclodextrin supramolecular nano-structure. Materials and methods This nanostructure contains iron oxide nanoparticles in the core surrounded with three polymeric layers including polymeric β-cyclodextrin, polyacrylic acid conjugated to sulfadiazine, and polyethylenimine functionalized with β-cyclodextrin. Sulfadiazine is a pH-responsive hydrophobic component capable of making inclusion complex with β-cyclodextrin available in the first and third layers. Doxorubicin, as an anti-cancer drug model, was chosen and the drug loading and release pattern were determined at normal and acidic pH. Moreover, the biocompatibility of the nanocapsule (with/without drug component) was examined using different techniques such as MTT assay, complement activation, coagulation assay, and hemolysis. Results The results revealed the successful preparation of a spherical nanocapsule with mean size 43±1.5 nm and negatively charge of −43 mV that show 160% loading efficacy. Moreover, the nanocapsule has an on/off switching release pattern in response to pH that leads to drug released in low acidic pH. The results of the biocompatibility tests indicated that this nano drug delivery system had no effect on blood and immune components while it could affect cancer cells even at very low concentrations (0.3 μg mL −1 ). Conclusion The obtained results suggest that this is a “switchable” theranostic nanocapsule with potential application as an ideal delivery system for simultaneous cancer diagnosis and therapy.

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Section: Resultsmentioning

confidence: 99%

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

Zarepour

Zarrabi

Larsen

2019

IJN

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“…A study was done to increase the brain uptake of R-HCl through chitosan nanoparticles prepared by a conventional emulsification crosslinking method. Coupling nanotechnology with surfactant coating on the chitosan nanoparticles resulted in enhanced brain targeting of the encapsulated drug [121].…”

Section: Chitosan In Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based (Nano)Materials for Novel Biomedical Applications

et al. 2019

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Chitosan-based nanomaterials have attracted significant attention in the biomedical field because of their unique biodegradable, biocompatible, non-toxic, and antimicrobial nature. Multiple perspectives of the proposed antibacterial effect and mode of action of chitosan-based nanomaterials are reviewed. Chitosan is presented as an ideal biomaterial for antimicrobial wound dressings that can either be fabricated alone in its native form or upgraded and incorporated with antibiotics, metallic antimicrobial particles, natural compounds and extracts in order to increase the antimicrobial effect. Since chitosan and its derivatives can enhance drug permeability across the blood-brain barrier, they can be also used as effective brain drug delivery carriers. Some of the recent chitosan formulations for brain uptake of various drugs are presented. The use of chitosan and its derivatives in other biomedical applications is also briefly discussed.

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“…More recently, Ray et al [ 80 ] used P80-coated CsNPs to deliver ropinirole hydrochloride (RH) for the treatment of Parkinson’s disease, enhancing RH brain uptake [ 81 ]. Indeed, crosslinking RH with CsNPs is needed, since RH has a very short bioavailability and half-life after oral administration and does not cross the BBB after parenteral administration [ 82 ].…”

Section: Coated Chitosan Nanoparticles For Receptor Mediated Transmentioning

confidence: 99%

“…Further, the brain/blood ratio of RH loaded in P80-coated CsNPs was higher than for RH loaded into uncoated CsNPs. All of these findings indicate that P80-coated CsNPs were able to target the brain by crossing the BBB owing to the coating with P80 [ 80 ].…”

Section: Coated Chitosan Nanoparticles For Receptor Mediated Transmentioning

confidence: 99%

Overcoming the Blood-Brain Barrier: Functionalised Chitosan Nanocarriers

et al. 2020

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The major impediment to the delivery of therapeutics to the brain is the presence of the blood-brain barrier (BBB). The BBB allows for the entrance of essential nutrients while excluding harmful substances, including most therapeutic agents; hence, brain disorders, especially tumours, are very difficult to treat. Chitosan is a well-researched polymer that offers advantageous biological and chemical properties, such as mucoadhesion and the ease of functionalisation. Chitosan-based nanocarriers (CsNCs) establish ionic interactions with the endothelial cells, facilitating the crossing of drugs through the BBB by adsorptive mediated transcytosis. This process is further enhanced by modifications of the structure of chitosan, owing to the presence of reactive amino and hydroxyl groups. Finally, by permanently binding ligands or molecules, such as antibodies or lipids, CsNCs have showed a boosted passage through the BBB, in both in vivo and in vitro studies which will be discussed in this review.

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Polysorbate 80 coated crosslinked chitosan nanoparticles of ropinirole hydrochloride for brain targeting

Cited by 104 publications

References 39 publications

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

Chitosan-Based (Nano)Materials for Novel Biomedical Applications

Overcoming the Blood-Brain Barrier: Functionalised Chitosan Nanocarriers

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