Polysomy 13 in a canine prostate carcinoma underlining its significance in the development of prostate cancer

Winkler, Susanne; Reimann-Berg, Nicola; Escobar, Hugo Murua; Loeschke, Siegfried; Eberle, N.; Höinghaus, R.; Nolte, Ingo; Bullerdiek, Jörn

doi:10.1016/j.cancergencyto.2006.03.015

Cited by 19 publications

(15 citation statements)

References 35 publications

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“…Comparing the results of the present report, where polysomy 13 is present in addition to numerous complex karyotype changes, with the results of the report by Winkler et al [2006], where polysomy 13 is the sole cytogenetic aberration, we can hypothesize that additional copies of canine chromosome 13 might be involved in the progression as well as in the initiation of the prostate cancer. In all 3 cases, centric fusions of 2 chromosomes 13 were observed.…”

Section: Discussionsupporting

confidence: 66%

“…fusion of chromosomes 1 and 2 and chromosomes 4 and 5 [Winkler et al, 2005]. The second report describes polysomy 13 in a canine prostate carcinoma showing centric fusions of several copies of chromosome 13 [Winkler et al, 2006]. Here, we present 2 cases of canine metastatic prostate cancer showing polysomy 13 along with complex karyotype changes.…”

mentioning

confidence: 87%

“…However, due to its distinctive banding pattern, it is possible to identify canine chromosome 13 by GTG-banding alone. Numerical aberrations of canine chromosome 13 are frequently observed in canine tumors [Hahn et al, 1994;Reimann et al, 1999b;Thomas et al, 2003;Winkler et al, 2005Winkler et al, , 2006. Therefore it is likely to assume that the canine chromosome 13 contains a gene or gene clusters which are involved in the multistep cascade of tumor initiation and progression.…”

Section: Discussionmentioning

confidence: 99%

“…Reports concerning chromosomal aberrations in canine tumors are generally rare. To the best of our knowledge there are only 2 reports about cytogenetic investigations in canine prostate tumor tissue [Winkler et al, 2005[Winkler et al, , 2006. The first report describes the karyotype analysis of a cell line (CT1258) derived from a canine prostate carcinoma.…”

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confidence: 99%

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Two New Cases of Polysomy 13 in Canine Prostate Cancer

Reimann-Berg

Willenbrock

Escobar

et al. 2010

Cytogenet Genome Res

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Besides man, the dog is the only known mammalian species that spontaneously develops carcinomas of the prostate with considerable frequency. For this reason, the dog is considered to be the only useful animal model for spontaneously occurring prostate malignancies in man. Cytogenetic investigations of human prostate cancers have revealed the frequent occurrence of trisomies 7, 8, and 17. Chromosome analyses of canine prostate carcinomas are rare. In this report we present 2 cases of canine prostate cancer showing a clonal polysomy 13 along with complex karyotype changes. Along with a previous report demonstrating polysomy 13 as the only karyotype deviation in a canine prostate cancer the present report supports the hypothesis that in canine prostate cancer, polysomy 13 is a recurrent cytogenetic aberration linked to the development of the disease. As human chromosomes (HSA) 8q and 4q and the canine chromosome (CFA) 13 share high homology, these results suggest that a conserved area on these chromosomes is involved in tumorigenesis in both species.

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Section: Discussionsupporting

confidence: 66%

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confidence: 87%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Two New Cases of Polysomy 13 in Canine Prostate Cancer

Reimann-Berg

Willenbrock

Escobar

et al. 2010

Cytogenet Genome Res

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“…A similar approach has now begun to form an active component of veterinary biomedical research. For example, tumor-associated CNAs have been detected in a diverse range of domestic dog cancers (Thomas et al 2003(Thomas et al , 2009aSargan et al 2005;Winkler et al 2006;CourtayCahen et al 2008;Devitt et al 2009 and others). The ability to extrapolate cytogenetic data between dog and human counterparts of the same tumor, based on their common ancestry, is now revealing intriguing evidence for tumor-associated CNAs that are evolutionarily conserved between species (for example, Breen and Modiano 2008).…”

Section: Introductionmentioning

confidence: 95%

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

et al. 2009

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Injection-site-associated sarcomas (ISAS), commonly arising at the site of routine vaccine administration, afflict as many as 22,000 domestic cats annually in the USA. These tumors are typically more aggressive and prone to recurrence than spontaneous sarcomas (non-ISAS), generally receiving a poorer long-term prognosis and warranting a more aggressive therapeutic approach. Although certain clinical and histological factors are highly suggestive of ISAS, timely diagnosis and optimal clinical management may be hindered by the absence of definitive markers that can distinguish between tumors with underlying injection-related etiology and their spontaneous counterpart. Specific nonrandom chromosome copy number aberrations (CNAs) have been associated with the clinical behavior of a vast spectrum of human tumors, providing an extensive resource of potential diagnostic and prognostic biomarkers. Although similar principles are now being applied with great success in other species, their relevance to feline molecular oncology has not yet been investigated in any detail. We report the construction of a genomic microarray platform for detection of recurrent CNAs in feline tumors through cytogenetic assignment of 210 large-insert DNA clones selected at intervals of approximately 15 Mb from the feline genome sequence assembly. Microarray-based profiling of 19 ISAS and 27 non-ISAS cases identified an extensive range of genomic imbalances that were highly recurrent throughout the combined panel of 46 sarcomas. Deletions of two specific regions were significantly associated with the non-ISAS phenotype. Further characterization of these regions may ultimately permit molecular distinction between ISAS and non-ISAS, as a tool for predicting tumor behavior and prognosis, as well as refining means for therapeutic intervention.

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The dog as a possible animal model for human non‐Hodgkin lymphoma: a review

Marconato

Gelain

Comazzi

2012

Hematological Oncology

139

142

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Lymphoma represents the most frequent hematopoietic cancer in dogs, and it shows significant overlap with the human disease. Several environmental factors have been associated with canine lymphoma, suggesting that they may contribute to lymphomagenesis. Canine lymphoma often presents in advanced stage (III-V) at diagnosis and, most commonly, has an aggressive clinical course requiring prompt treatment, which relies on the use of polychemotherapy. In this review, we will summarize the state-of-the-art of canine lymphoma epidemiology, pathobiology, diagnostic work-up and therapy, and will highlight the links to the corresponding human disease, providing evidence for the use of dog as an animal model of spontaneous disease.

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Polysomy 13 in a canine prostate carcinoma underlining its significance in the development of prostate cancer

Cited by 19 publications

References 35 publications

Two New Cases of Polysomy 13 in Canine Prostate Cancer

Two New Cases of Polysomy 13 in Canine Prostate Cancer

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

The dog as a possible animal model for human non‐Hodgkin lymphoma: a review

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