Polysomnography findings in pediatric spinal muscular atrophy types 1–3

Chacko, Archana; Sly, Peter D.; Gauld, L.

doi:10.1016/j.sleep.2019.12.004

Cited by 28 publications

(27 citation statements)

References 35 publications

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“…19 Whilst in DMD the nocturnal features have been associated with the stages of progression of the disease, 7,13 in spinal muscular atrophy the prevalence of SDB has been defined by a relatively small number of studies, and its association with NHH has not been fully clarified. 20,21 In conclusion, the path to the Holy Grail of the perfect predictor to NHH is still quite long. A disease-specific approach for SDB in neuromuscular conditions is most likely going to be the key.…”

Section: Daytime Predictors Of Nocturnal Hypercapnic Hypoventilation ...mentioning

confidence: 96%

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Daytime predictors of nocturnal hypercapnic hypoventilation in children with neuromuscular disorders—The Holy Grail

Trucco

2022

Pediatric Pulmonology

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Section: Daytime Predictors Of Nocturnal Hypercapnic Hypoventilation ...mentioning

confidence: 96%

“…Whilst in DMD the nocturnal features have been associated with the stages of progression of the disease, 7,13 in spinal muscular atrophy the prevalence of SDB has been defined by a relatively small number of studies, and its association with NHH has not been fully clarified 20,21 …”

Section: Study Population Design Nhh Definition Daytime Predictor Of ...mentioning

confidence: 99%

Daytime predictors of nocturnal hypercapnic hypoventilation in children with neuromuscular disorders—The Holy Grail

Trucco

2022

Pediatric Pulmonology

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“…It is worth noting that within the populations of children discussed in this study, several are predisposed to concomitant sleep‐disordered breathing. OSA is commonly seen in patients with cerebral palsy 40 and Duchenne muscular dystrophy, 41 and central sleep apnea is described in spinal muscular atrophy 42 and myotonic dystrophy. Preoperative awareness of existing sleep‐disordered breathing may allow for intraoperative and postoperative mitigation of risk.…”

Section: Assessing Risk In Your Patientmentioning

confidence: 99%

Respiratory prehabilitation in pediatric anesthesia in children with muscular and neurologic disease

St‐Laurent

Zysman-Colman

Zielinski

2021

Pediatric Anesthesia

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Children with chronic neurologic and chest wall diseases are at increased risk of postoperative respiratory complications. These complications include acute respiratory failure, atelectasis, pneumonia, need for reintubation, and need for tracheostomy and can carry significant negative impacts on patient outcomes, including mortality, and increased healthcare resource utilization. 1 As such, careful examination of risk factors in these complex children should be initiated in order to plan appropriate preoperative and postoperative interventions that help mitigate postoperative respiratory complications. Such interventions may preoperatively include initiation of respiratory support devices such as non-invasive ventilation (NIV) and airway clearance techniques and/or a plan

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“…The more severe the case, the more likely children are to have various respiratory complications, including sleep-disordered breathing, recurrent pneumonia and ARF. 2,3 Appropriate and effective strategies of respiratory management are crucial to stabilize lung function and reduce the incidence of respiratory complications and mortality in children with SMA. The literature and expert opinion support using a sleep study to confirm when a patient has sleep-disordered breathing and needs to use noninvasive ventilation to prevent recurrent respiratory tract infections (RRTIs) and ARF.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for recurrent respiratory tract infections or acute respiratory failure in children with spinal muscular atrophy

Guo

Meng

Cao

2022

Preprint

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Introduction: Assessment of and intervention for sleep-disordered breathing and malnutrition are related to respiratory management for preventing recurrent respiratory tract infections (RRTIs) and acute respiratory failure (ARF) in children with spinal muscular atrophy (SMA). However, the specific standard has not been clarified. Purpose: The study aimed to obtain the risk factors and the predictive index for RRTIs and/or ARF in children with SMA. Methods: In this retrospective study, the differences in clinical characteristics in patients with or without RRTIs and ARF were compared, and binary logistic regression analysis was carried out. The best cutoff points of the positive predictive index were obtained. Results: Type 1 (OR = 4.12, 95% CI 1.30-13.07, P =.016) and apnea hypopnea index (AHI) (OR = 1.14, 95% CI 1.05-1.24, P =.001) were risk factors, while body mass index z score (BMIz) (OR = 0.68, 95% CI 0.49-0.94, P =.018) and mean pulse oxygen saturation (MSpO ) (OR = 0.67, 95% CI 0.50-0.91, P =.010) were protective factors. The sensitivity and specificity of the standard of MSpO < 96% and AHI > 10 events/h or BMIz < -1 with the occurrence of RRTIs and/or ARF were 0.513 and 0.957, respectively. Conclusion: SMA Type 1, BMIz, AHI and MSpO should be used to estimate the risk for RRTI or ARF in children with SMA. MSpO < 96%, and AHI > 10 events/h or BMIz < -1 should be used as the intervention standard.

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Polysomnography findings in pediatric spinal muscular atrophy types 1–3

Cited by 28 publications

References 35 publications

Daytime predictors of nocturnal hypercapnic hypoventilation in children with neuromuscular disorders—The Holy Grail

Daytime predictors of nocturnal hypercapnic hypoventilation in children with neuromuscular disorders—The Holy Grail

Respiratory prehabilitation in pediatric anesthesia in children with muscular and neurologic disease

Risk factors for recurrent respiratory tract infections or acute respiratory failure in children with spinal muscular atrophy

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