Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi.

Abstract

Anti-inflammatory assays on the carrageenin-induced edema and scald-induced hyperalgesia in the hindpaw of rats were studied on polysaccharides obtained from the fruit bodies of various fungi (polysaccharide AC, BC: Tremella fuciformis;MEA, MHA, MCW-A, MCW-N: Auricularia auricula-judae; T-2-HN: Dictophora indusiata;G-A: Ganoderma japonicum). The purified polysaccharides MHA, MCW-A, G-A and T-2-HN exhibited a significant inhibitory effect on carrageenin edema. Among these polysaccharides, T-2-HN (partially O-acetylated alpha-D-mannan) also showed the marked inhibitory effect on scald hyperalgesia. We have found that T-2-HN has more potent anti-inflammatory activity than phenylbutazone in the above two inflammatory models. Since the purified polysaccharide is free from protein and lipid, it is clear that anti-inflammatory effect arises from the polysaccharide itself. The polysaccharides (T-2-HN, locust bean gun, xanthan gum) had little effect on the metabolism of arachidonic acid in canine platelets. The mechanism of the anti-inflammatory activity of the polysaccharide remains obscure.

O-Acetylation of Cryptococcal Capsular Glucuronoxylomannan Is Essential for Interference with Neutrophil Migration

“…O-Acetyl groups are common substituents of bacterial polysaccharides and generally determine immune reactivity and function as epitopes for Ab binding; other functions have scarcely been described (58 -60). The 6-O-acetylated (133)-␣-D-mannan from Dictyophora indusiata has been reported to have anti-inflammatory capacity by unknown mechanisms (61,62). Additionally, no neutrophil receptors are known to bind O-acetylated glycan.…”

Molecular characterization of a glycoside hydrolase family-51 α-L-arabinofuranosidase from Auricularia auricula

“…It is one of the most cultivated mushrooms in the world due to its high nutritive, economic and medicinal value [1]. It has potential anti-tumour, anti-inflammatory, hypoglycemic, hypolipidemic and anticoagulant characteristics [2][3][4][5][6]. Furthermore, its extracts have been reported to possess antioxidant and radical scavenging properties [7][8][9].…”

Effect effects of <i>Auricularia auricula</i> polysaccharides on exhaustive swimming exercise-induced oxidative stress in mice

“…The main monosaccharide That make up the polysaccharides from Auricularia auricula (AAPs) are glucose (72 %), mannose (8 %), xylose (10 %), and fucose (10 %). The polysaccharide backbone chain is (1→3) β-D-glucans [3]. Recent scientific evidence suggest that AAPs have multiple biological activities, including antioxidant, antiviral, antiinflammatory, anti-tumor, hypoglycemic, hypolipidemic, anticoagulant, and anticomplement activities as well as cardioprotective effects [4].…”