Polysaccharides in Cancer Prevention: From Bench to Bedside

Banerjee, Sanjeev; Parasramka, Mansi; Paruthy, Shivani B.

doi:10.1007/978-3-319-03751-6_26-1

Cited by 2 publications

(3 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mushroom non-cellulosic β-glucans act as “biological response modifiers” or “biotherapy,” a type of treatment that uses substances contrived from living organisms to treat disease, enhancing the body's own use of macrophages and T-lymphocytes, rather than directly attacking any tumors ( 69 ).…”

Section: Bioactive Molecules Of Mushroomsmentioning

confidence: 99%

“…We have investigated the immune modulation role of mushroom biomass of Coriolus versicolor in neuroinflammation and neurohormesis and the emerging role of lipoxinA4 and inflammasome in progressive neurodegenerative disorders and distinct configurations of chronic mental illness, proposing a potentially innovative treatment ( 69 ).…”

Section: Neuroprotective Aptitude Of Mushroomsmentioning

confidence: 99%

See 1 more Smart Citation

Mushrooms as future generation healthy foods

Bell

Silva

Guina³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role in shielding people against the side effects of an unhealthy stylish diet is reviewed. Mushrooms complement the human diet with various bioactive molecules not identified or deficient in foodstuffs of plant and animal sources, being considered a functional food for the prevention of several human diseases. Mushrooms have been widely used as medicinal products for more than 2,000 years, but globally the potential field of use of wild mushrooms has been untapped. There is a broad range of edible mushrooms which remain poorly identified or even unreported which is a valuable pool as sources of bioactive compounds for biopharma utilization and new dietary supplements. Some unique elements of mushrooms and their role in preventative healthcare are emphasized, through their positive impact on the immune system. The potential of mushrooms as antiviral, anti-inflammatory, anti-neoplastic, and other health concerns is discussed. Mushrooms incorporate top sources of non-digestible oligosaccharides, and ergothioneine, which humans are unable to synthesize, the later a unique antioxidant, cytoprotective, and anti-inflammatory element, with therapeutic potential, approved by world food agencies. The prebiotic activity of mushrooms beneficially affects gut homeostasis performance and the balance of gut microbiota is enhanced. Several recent studies on neurological impact and contribution to the growth of nerve and brain cells are mentioned. Indeed, mushrooms as functional foods' nutraceuticals are presently regarded as next-generation foods, supporting health and wellness, and are promising prophylactic or therapeutic agents.

show abstract

Section: Bioactive Molecules Of Mushroomsmentioning

confidence: 99%

Section: Neuroprotective Aptitude Of Mushroomsmentioning

confidence: 99%

Mushrooms as future generation healthy foods

Bell

Silva

Guina³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Macromycetes are recognized as cell factories that produce a great diversity of bioactive compounds such as polyketides, terpenoids and polysaccharides (Phan et al 2015;Yaoita et al 2015;Wang et al 2017). These compounds have shown therapeutic potential associated to their specific cytotoxicity in cellular lines such a fibroblasts and tumors; among which, larynx, ovary, mammary, lung cancer and human leukemia are highlighted (Kidd 2000;Wasser 2003;Banerjee et al 2015). Other cytotoxicity reports have been linked to macromycete extracts on amastigotes of Leishmania amazonensis and inhibitory activity of the trypanothion reductase enzyme of Trypanosoma cruzi (TryR) (Rosa et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic activity of ethanolic extracts of a selection of macromycetes

2018

View full text Add to dashboard Cite

Macromycetes are an important factory of bioactive compounds, which have shown to have therapeutic use given their specific cytotoxicity, turning them into new and natural source of pharmaceuticals for treatments against several diseases. The purpose of this paper was to collect new data on the chemical and biological knowledge of the mycobiota that grows wild in the city of Ibagué (Colombia), in order to try to understand the cytotoxicity of these organisms. Based on abundance and chemotaxonomic criteria and in order to evaluate their biological activity, basidiomes of the following species were collected: Pycnoporus sanguineus, Phellinus gilvus, Pleurotus tubarius, Lenzites elegans and Ganoderma australe. An ethanolic maceration of basidiomes was used as base to perform cytogenotoxicity tests on Allium cepa. The extracts of P. sanguineus and G. australe inhibited A. cepa mitosis in 58.92 % at 8000 mg l -1 and 53.81% at 2000 mg l -1 , respectively. The extracts of the studied species have shown capacity to cause some genetic changes associated to the concentrations evaluated. This study shows that there is an important potential in wild macromycete biodiversity in the region of Tolima (Colombia), making them potential candidates for future research on clinical essays for the pharmaceutical industry.

show abstract

Polysaccharides in Cancer Prevention: From Bench to Bedside

Cited by 2 publications

References 125 publications

Mushrooms as future generation healthy foods

Mushrooms as future generation healthy foods

Cytotoxic activity of ethanolic extracts of a selection of macromycetes

Contact Info

Product

Resources

About