Polysaccharides from radix astragali exert immunostimulatory effects to attenuate the dampness stagnancy due to spleen deficiency syndrome

Zhao, Wenxiao; Chen, Lijun; Cui, Ning; Ji, Xuming; Jiang, Haiqiang; Deng, Tiantian; Wang, Shijun

doi:10.4103/pm.pm_503_18

Cited by 5 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vivo studies indicated that the APS of 8 mg/kg could improve the immunity by promoting the proliferation of T and B cells, and producing a variety of cytokines in cyclophosphamide-induced immunosuppressive mice, such as IgG, IgA, IgM, TNF-α, IL-6, IL-2 and IFN-γ [ 93 ]. In previous studies, the APS of 300–1200 mg/kg improved the percentages of CD3 + CD4 + T cells and CD3 + , and decreased the ratio of CD3 + CD8 + /CD3 + CD4 + and the expression of IL-10, IL-6 and TNF-α [ 94 ].…”

Section: Pharmacological Activities Of Bioactive Ingredientsmentioning

confidence: 99%

Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from Astragalus membranaceus

Dong

Yang

et al. 2023

Molecules

View full text Add to dashboard Cite

Astragalus membranaceus (A. membranaceus), a well-known traditional herbal medicine, has been widely used in ailments for more than 2000 years. The main bioactive compounds including flavonoids, triterpene saponins and polysaccharides obtained from A. membranaceus have shown a wide range of biological activities and pharmacological effects. These bioactive compounds have a significant role in protecting the liver, immunomodulation, anticancer, antidiabetic, antiviral, antiinflammatory, antioxidant and anti-cardiovascular activities. The flavonoids are initially synthesized through the phenylpropanoid pathway, followed by catalysis with corresponding enzymes, while the triterpenoid saponins, especially astragalosides, are synthesized through the universal upstream pathways of mevalonate (MVA) and methylerythritol phosphate (MEP), and the downstream pathway of triterpenoid skeleton formation and modification. Moreover, the Astragalus polysaccharide (APS) possesses multiple pharmacological activities. In this review, we comprehensively discussed the biosynthesis pathway of flavonoids and triterpenoid saponins, and the structural features of polysaccharides in A. membranaceus. We further systematically summarized the pharmacological effects of bioactive ingredients in A. membranaceus, which laid the foundation for the development of clinical candidate agents. Finally, we proposed potential strategies of heterologous biosynthesis to improve the industrialized production and sustainable supply of natural products with pharmacological activities from A. membranaceus, thereby providing an important guide for their future development trend.

show abstract

Section: Pharmacological Activities Of Bioactive Ingredientsmentioning

confidence: 99%

Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from Astragalus membranaceus

Dong

Yang

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Durazzo

Nazhand

Lucarini

et al. 2021

Rend. Fis. Acc. Lincei

View full text Add to dashboard Cite

Medicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and treatment of several diseases, as an alternative to chemical drugs. The current work provided a comprehensive overview and analysis of the Astragalus and health relationship in literature. The analysis of their therapeutic potential is thus instrumental to understand their bioactivity. Among these, the flowering medicinal plant Astragalus membranaceus has raised interest due to several beneficial health effects. This perspective review discussed the botanical, geographical, historical, and the therapeutic properties of A. membranaceus, with a special focus on its health improving effects and medicinal applications both in vitro and in vivo. Graphic abstract

show abstract

Astragalus polysaccharide: a review of its immunomodulatory effect

Liu

Zhang

et al. 2022

Arch. Pharm. Res.

View full text Add to dashboard Cite

Polysaccharides from radix astragali exert immunostimulatory effects to attenuate the dampness stagnancy due to spleen deficiency syndrome

Cited by 5 publications

References 5 publications

Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from Astragalus membranaceus

Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from Astragalus membranaceus

Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role

Astragalus polysaccharide: a review of its immunomodulatory effect

Contact Info

Product

Resources

About