Polysaccharides from Atractylodes macrocephala Koidz. Ameliorate ulcerative colitis via extensive modification of gut microbiota and host metabolism

Feng, Wuwen; Liu, Juan; Tan, Yuzhu; Ao, Hui; Wang, Jing; Peng, Cheng

doi:10.1016/j.foodres.2020.109777

Cited by 77 publications

(50 citation statements)

References 42 publications

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“…AM has been shown to promote the intestinal healing process following intestinal injury in a number of intestinal disorders [ 15 ]. In addition, polysaccharides from AM (AMP) has been demonstrated to effectively alleviate colitis [ 16 ]. Thus, considering combined treatment, whether MSCs combined with AMP could improve the therapeutic effect on colitis raised our interest.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Bone marrow mesenchymal stem cells combined with Atractylodes macrocephala polysaccharide attenuate ulcerative colitis

Zheng

Wang

2021

Bioengineered

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The aim of the present study was to explore the effects of bone marrow mesenchymal stem cells (BMSCs), combined with Atractylodes macrocephala polysaccharide (AMP), in an experimental model of ulcerative colitis. BMSCs were first isolated, cultured, and identified by flow cytometry. A rat model of colitis was established by trinitrobenzene sulfonic acid (TNBS) injection. Rats were treated with BMSCs with or without AMP for 1 or 2 weeks. H&E staining was performed to assess the extent of histological injury. IEC-6 and BMSCs were co-cultured and treated with AMP. Cell migration was measured using the Transwell assay, whilst the levels of cytokines in the rat blood samples were detected using ELISA. In addition, cytokine levels in the cell supernatant were measured by microarray. The results showed that BMSCs were successfully isolated. BMSCs treatment could markedly alleviate injury according to histological analysis and regulate inflammatory cytokine production in this rat model of TNBS-induced colitis, where a higher number of BMSCs was found in the intestinal tract, compared to the model. AMP not only potentiated the effects of BMSCs on preventing TNBS-induced colitis but also promoted BMSC homing to the injured tissue and regulated cytokines. Furthermore, BMSCs and AMP promoted the migration of IEC in vitro and influenced multiple genes. In conclusion, AMP treatment improved the therapeutic effects of BMSCs on ulcerative colitis, potentially providing a novel clinical treatment strategy for colitis.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Bone marrow mesenchymal stem cells combined with Atractylodes macrocephala polysaccharide attenuate ulcerative colitis

Zheng

Wang

2021

Bioengineered

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“…Polysaccharides are important active ingredients of Atractylodes macrocephala , and Feng et al. found Atractylodes polysaccharides to increase beneficial bacteria, such as Lactobacillus and Butyricicoccus , affect the metabolic process of amino acids and bile acids, and reverse the damaged intestinal-tissue structure in UC model mice ( Feng et al., 2020 ); in addition, its ethanol extract can also repair intestinal mucosal injury and reduce serum IL-1β and LPS levels in T2D mice ( Zhang et al., 2017 ). Saponins are the main active components of ginseng and have anti-inflammatory and metabolic regulatory effects ( Gao et al., 2020 ).…”

Section: Tcm Research Progress In the Treatment Of Uc And T2dmmentioning

confidence: 99%

Gut Microbiota: The Potential Key Target of TCM’s Therapeutic Effect of Treating Different Diseases Using the Same Method—UC and T2DM as Examples

Zhang

Liu

Yang

et al. 2022

Front. Cell. Infect. Microbiol.

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Traditional Chinese herbal medicine often exerts the therapeutic effect of “treating different diseases with the same method” in clinical practice; in other words, it is a kind of herbal medicine that can often treat two or even multiple diseases; however, the biological mechanism underlying its multi-path and multi-target pharmacological effects remains unclear. Growing evidence has demonstrated that gut microbiota dysbiosis plays a vital role in the occurrence and development of several diseases, and that the root cause of herbal medicine plays a therapeutic role in different diseases, a phenomenon potentially related to the improvement of the gut microbiota. We used local intestinal diseases, such as ulcerative colitis, and systemic diseases, such as type 2 diabetes, as examples; comprehensively searched databases, such as PubMed, Web of Science, and China National Knowledge Infrastructure; and summarized the related studies. The results indicate that multiple individual Chinese herbal medicines, such as Rhizoma coptidis (Huang Lian), Curcuma longa L (Jiang Huang), and Radix Scutellariae (Huang Qin), and Chinese medicinal compounds, such as Gegen Qinlian Decoction, Banxia Xiexin Decoction, and Shenling Baizhu Powder, potentially treat these two diseases by enriching the diversity of the gut microbiota, increasing beneficial bacteria and butyrate-producing bacteria, reducing pathogenic bacteria, improving the intestinal mucosal barrier, and inhibiting intestinal and systemic inflammation. In conclusion, this study found that a variety of traditional Chinese herbal medicines can simultaneously treat ulcerative colitis and type 2 diabetes, and the gut microbiota may be a significant target for herbal medicine as it exerts its therapeutic effect of “treating different diseases with the same method”.

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“…Gut microbiota in patients with type II diabetes can be regulated using a decoction of Ge Gen Huang Lian to treat diabetes (21). The turbulence of gut microbiota metabolites, such as short-chain fatty acids and hosts, was extensively modulated by Atractylodes macrocephala to achieve the therapeutic effects (22)(23)(24). Scutellaria baicalensis Georgi polysaccharide can improve intestinal barrier function and modulate gut microbiota on dextran sulfate sodium-induced ulcerative colitis (25).…”

Section: Introductionmentioning

confidence: 99%

Effect of Traditional Chinese Medicine on the Gut Microbiota in Heat-Stressed Laying Hens

Bai

et al. 2022

Front. Vet. Sci.

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Gut microbiota plays an important role in health and disease. To determine whether the traditional Chinese formula Zi Huang Huo Xiang San (ZHHXS) modulates gut microbiota under heat stress, a heat stress model was prepared in Roman layer hens by housing them at temperatures of 32–36°C and administering ZHHXS for 4 weeks. The Roman egg layers were randomly divided into three groups with 10 hens in each: a ZHHXS treatment group (ZHHXS-HS), a heat-stressed group (HS), and a blank control group (BC). The ZHHXS-HS and HS groups were housed in a 34 ± 2°C environment, while the BC group was housed at 25 ± 1°C. The ZHHXS-HS hens were fed a diet supplemented with 1% ZHHXS from 1 to 28 days, while the other groups were not. Gut microbiota in the hens' feces was assessed through 16S rRNA high-throughput sequencing on days 1, 3, 7, 14, and 28. A plot of the PCA scores showed that the gut microbiota composition in the BC group was a similar trend in the ZHHXS-HS group on days 1 and 3. The principal coordinate analysis (PCoA) unweighted distribution showed that the gut microbiota composition had no significant differences between the BC and ZHHXS-HS groups on days 1 and 7. The PCoA weighted distribution showed that the gut microbiota composition had no significant differences between the BC and ZHHXS-HS groups on days 1 and 3. This study showed that the composition of gut microbiota in layer hens with heat stress was modulated by ZHHXS treatment. ZHHXS treatment caused key phylotypes of gut microbiota to match the BC group, particularly Actinobacteria, Bacteroidetes, Bacteroides, and Enterococcus. The effect of ZHHXS in alleviating heat stress could be achieved by altering the composition of gut microbiota and regulating some key phylotypes.

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Polysaccharides from Atractylodes macrocephala Koidz. Ameliorate ulcerative colitis via extensive modification of gut microbiota and host metabolism

Cited by 77 publications

References 42 publications

RETRACTED ARTICLE: Bone marrow mesenchymal stem cells combined with Atractylodes macrocephala polysaccharide attenuate ulcerative colitis

RETRACTED ARTICLE: Bone marrow mesenchymal stem cells combined with Atractylodes macrocephala polysaccharide attenuate ulcerative colitis

Gut Microbiota: The Potential Key Target of TCM’s Therapeutic Effect of Treating Different Diseases Using the Same Method—UC and T2DM as Examples

Effect of Traditional Chinese Medicine on the Gut Microbiota in Heat-Stressed Laying Hens

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