RETRACTED ARTICLE: Bone marrow mesenchymal stem cells combined with
            <i>Atractylodes macrocephala</i>
            polysaccharide attenuate ulcerative colitis

Zheng, Zhijuan; Wang, Junqing

doi:10.1080/21655979.2021.2012954

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…Bone marrow mesenchymal stem cell (BMSCs) could markedly alleviate injury according to histological analysis and regulate inflammatory cytokine in TNBS-induced UC. And Atractylodes macrocephala polysaccharide could potentiated the effects of BMSCs on preventing TNBS-induced UC, though homing to the injured tissue and regulated cytokines ( Zheng and Wang, 2022 ). The combination of NPs and other drugs has the potential to increase the therapeutic impact on UC to some level, which will be a key research focus in the future.…”

Section: Discussionmentioning

confidence: 99%

The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis

Guo

Cao

et al. 2022

Front. Pharmacol.

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Ulcerative colitis (UC) is an inflammatory bowel disease that is persistent and nonspecific. There are several medications available for the treatment of UC. However, conventional UC medications have substantial adverse effects, low clinical effectiveness, and a high recurrence rate. Therefore, it is critical to discover new medicines that are both safe and effective for UC patients. Natural polysaccharides offer a wide range of pharmacological benefits, including anti-inflammatory, anti-virus, anti-tumor, anti-aging, immune enhancement, and gut flora regulation. In the therapy of UC, natural polysaccharides can modulate inflammatory factors, the immune system, and intestinal flora, and preserve the intestinal mucosa. It demonstrates a good curative effect and is of safety to use, thereby being a potential treatment for UC patients. This paper covers the structure, the pharmacological effects on UC, and the mechanisms of natural polysaccharides. Finally, limitations, challenges, and perspectives are discussed. It is hoped that the findings of this publication will inspire more natural polysaccharides research and provide a theoretical foundation for the creation of new UC medications.

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Section: Discussionmentioning

confidence: 99%

The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis

Guo

Cao

et al. 2022

Front. Pharmacol.

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“…The repair and reconstruction of colonic mucosa rely primarily on colonic mucosa stem cells that can differentiate into mature colonic mucosa cells ( He et al, 2012b ). Bone mesenchymal stem cells (BMSCs) have good immune regulatory effects and homing feature that promotes migration to the injury site, adhesion, and colonization, in turn repairing and reconstructing the colonic mucosal tissue of UC ( Zheng and Wang, 2022 ). The differentiation, growth, migration, and homing of BMSCs are regulated by a combination of various factors, including several chemokines and adhesion molecules (such as ICAM-1, VCAM-1, and VLA-4) ( He et al, 2012a ).…”

Section: Studies Assessing the Mechanism Of Slbzp In The Treatment Of Ucmentioning

confidence: 99%

“…Additionally, polysaccharides from Atractylodes macrocephala Koidz. (540 mg/kg) could not only promote BMSC homing to the injured tissue and regulate cytokines such as IL-6, IL-10, IL-17 A, and TGF-β for preventing TNBS-induced rats colitis but also promote the migration of IEC in vitro and influence multiple genes ( Zheng and Wang, 2022 ). Han and colleagues reported that atractylenolide III (5, 10 mg/kg) could ameliorate DSS-induced colitis inflammatory and oxidative stress by regulating the MDA and GSH contents, SOD activity, and the expression of TNF-α, IL-6, COX-2, and iNOS mRNA.…”

Section: Pharmacological Studies Of a Single Chinese Herb And Its Act...mentioning

confidence: 99%

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Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms

2022

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Ulcerative colitis (UC), characterized by syndromes including abdominal pain, bloody stool, diarrhea, weight loss, and repeated relapse, is a non-specific inflammatory intestinal disease. In recent years, with the changing dietary habits in China, the incidence of UC has shown an upward trend. UC belongs to the category of recorded as “diarrhea,” “chronic dysentery,” and “hematochezia” in traditional Chinese medicine (TCM), and Shenling BaiZhu powder (SLBZP) is one of the most effective and commonly used prescriptions. In this review, we aim to systematically summarize the clinical application and pharmacological mechanism of SLBZP in the treatment of UC to provide a theoretical basis for its clinical use and experimental evaluation of SLBZP. Our results showed that both SLBZP and SLBZP in combination with chemical drugs, have a significant therapeutic effect against UC with few adverse reactions. Furthermore, combined therapy was better than western medicine. Further, pathophysiological studies indicated that SLBZP has anti-inflammatory, immunomodulatory, antioxidant effects, regulation relative cell signal transduction and regulation of gut microbiota. Although evidence suggests superior therapeutic efficacy of SLBZP for treating UC and the relative mechanism has been studied extensively, various shortcomings limit the existing research on the topic. There is a lack of UC animal models, especially UC with TCM syndromes, with no uniform standard and certain differences between the animal model and clinical syndrome. The dosage, dosage form, and therapeutic time of SLBZP are inconsistent and lack pharmacological verification, and clinical trial data are not detailed or sufficiently rigorous. In addition, SLSZP is composed of multiple Chinese drugs that contain massive numbers of ingredients and which or several components contribute to therapeutic effects. How they work synergistically together remains unknown. Therefore, on the one hand, large sample prospective cohort studies to clarify the clinical efficacy and safety of SLBZP in the treatment of UC are needed. In contrast, researchers should strengthen the study of the molecular biological mechanism of active ingredients and its synergistic actions, clarifying the mechanism of SLBZP in treating UC by multi-component, multi-target, and multi-pathway.

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“…These costly treatments have unpredictable efficacy, significantly burdening individuals, families, and society. [8,9] The rising prevalence of UC and the absence of safe and effective treatments JW, TYM and HYZ contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Global trends and hotspots of ulcerative colitis based on bibliometric and visual analysis from 1993 to 2022

Wang,

Mao,

Zhou

et al. 2024

Medicine

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Ulcerative colitis (UC) has seen a significant increase over the past 3 decades. However, our understanding of its etiology, pathogenesis, and pharmacological treatment remains limited. This comprehensive review aims to address these gaps by analyzing trends, evaluating previous research, and providing insights for future investigations. We conducted a bibliometric analysis of UC-related papers indexed in the Web of Science from 1993 to 2022. The author, organization, country, and keyword networks in the field of UC were visualized. A total of 36,483 papers were included, showing a continuous upward trend. Most research on UC was conducted in universities, with hospitals leading in high-quality studies. The United States emerged as the primary contributor, followed by China and the United Kingdom. The overall quality of UC-related publications improved, indicating sustained interest in the field. The keywords related to UC was classified into 9 clusters. Keywords detection revealed that UC research focused mainly on the discovery of its etiology and exploration of treatment methods, with research directions evolving from initial treatment of UC and related diseases to clinical trials of UC and subsequently incorporating genomics and bioinformatics techniques to study UC and explore new therapeutic methods and drugs, including recent advances in gut microbiota. Our study identified gaps in understanding the etiology, pathogenesis, and treatment of UC. Future research in UC should focus on genomics, personalized treatment, microbial therapy and leveraging machine learning and artificial intelligence. These areas hold the potential for improving UC diagnosis, treatment, and management.

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RETRACTED ARTICLE: Bone marrow mesenchymal stem cells combined with Atractylodes macrocephala polysaccharide attenuate ulcerative colitis

Cited by 6 publications

References 32 publications

The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis

The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis

Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms

Global trends and hotspots of ulcerative colitis based on bibliometric and visual analysis from 1993 to 2022

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